Accelerated Epigenetic Age and Cardiovascular Risk Factors
Epigenetic patterns determine the behavior of a cell, and change constantly in response to cell state and the surrounding tissue environment. Epigenetic state can be used to measure biological age, the epigenetic clock. When an epigenetic clock indicates an age older than chronological age, that is referred to as epigenetic age acceleration. While the clocks are not fully understood in detail, it is thought that the specific epigenetic changes measured are reflective of the burden of cell and tissue damage and dysfunction that causes aging. This acceleration has been shown to correlate with risk and status of a number of a...
Source: Fight Aging! - November 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Small Molecule Induction of Stem Cell Behavior Applied to Tendon Aging
In this study, we employed the newly developed system, DLEPS, which is an efficacy prediction system using transcriptional profiles with deep learning, to identify potential drugs to stimulate stemness.
In our study, we found that the top-ranked candidate compound prim-O-glucosylcimifugin (POG) could efficiently inhibit TSPC senescence and promote their tenogenic differentiation potential in an in vitro serial passaging cell senescence model. We also found that the top-ranked POG potently rejuvenated the proliferation and tenogenic potential of TSPCs from both aged rats and middle-aged humans by maintaining stemnes...
Source: Fight Aging! - November 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Towards Clearance of Senescent Cells to Improve Heart Regeneration
Senescent cells accumulate with age in tissues throughout the body. Cells enter a senescent state constantly throughout life, largely the result of cells reaching the Hayflick limit on replication, but also due to stress, injury, and damage. A senescent cell ceases replication and instead produces a potent mix of pro-growth, pro-inflammatory signals. The primary purpose of senescence in an adult is to signal to the immune system that a cell needs to be removed, and potentially that the surrounding region of tissue requires further attention, such as in the case of an injury or toxic environment that is damaging other cells...
Source: Fight Aging! - October 31, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing the Role of Insulin in Aging
The relationship between insulin metabolism and aging is one of the most studied areas of the field, with decades of researchers putting in time to deepen the understanding of the web of interactions surrounding insulin. Yet this has failed to lead to any practical outcome when it comes to slowing or reversing aging. Researchers now have an incrementally better idea as to why obesity, metabolic syndrome, and type 2 diabetes shorten life and worsen health, but that was well understood to be the case well prior to the advent of modern biotechnology.
Experimental studies in animal models of aging such as nematodes, f...
Source: Fight Aging! - October 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Glial Cell Mitochondrial Stress Can Indirectly Signal to the Whole Organism
Glia of various sorts are supporting cells in the brain, assisting the function of neurons. Dysfunction and stress in glial cells is nonetheless important. A growing body of evidence suggests that cellular senescence in astrocytes and microglia contribute to age-related neurodegenerative conditions, for example. Further, stress of various forms in these cells may be provoking both inflammation and altered signaling throughout the brain and body. Overly active, pro-inflammatory astrocytes and microglia are implicated in neurodegeneration, even when these cells are not senescent. It isn't clear as to how much of this is a re...
Source: Fight Aging! - October 30, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
« Back to Top (Source: Fight Aging!)
Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Contribute to the Degeneration of the Retinal Vasculature
Senescent cells accumulate with age throughout the body. While their numbers remain a small fraction of all cells in a tissue, even in late life, senescent cells produce an outsized harm to tissue structure and function via a continual, disruptive, pro-growth, pro-inflammatory signaling, the senescence-associated secretory phenotype (SASP). Researchers have demonstrated, in animal models, that senescent cells directly contribute to the onset and progression of many distinct age-related conditions. Further, it has been shown in animal models that clearing senescent cells throughout the body can rapidly reverse pathology in ...
Source: Fight Aging! - October 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Producing Alzheimer's Symptoms in Rats via a Transplanted Gut Microbiome
The gut microbiome changes with age, the relative population sizes of the many distinct microbial species altering to provoke chronic inflammation and potentially other, more complex issues driven by changes in the production of beneficial and harmful metabolites. With the advent of ways to cheaply assess the contents of the gut microbiome, researchers are finding that a number of age-related conditions appear characterized by dysbiosis, growth in the population of specific harmful microbial species. One of those conditions is Alzheimer's disease, which has a puzzling incidence that doesn't track well with the well establi...
Source: Fight Aging! - October 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
AI (Re)Defining Pharmaceutical Exclusivities
This article ’s central thesis is twofold. First, the increased use of artificial intelligence (AI) technology, biomarkers, and new communications technologies... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - October 26, 2023 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
A DNA Methylation Marker of Age in Mitochondrial DNA
In this study, we present a novel, reliable, PCR-based (i.e., sequence-specific) 6mA detection method that is free of technological artifacts and show in several genetic models that relative 6mA levels at different mtDNA sites (these levels actually show that how many percent of the individual mitochondrial genomes present in a given tissue sample are methylated at a selected adenine nucleobase) are significantly related to the age of the organism. Thus, N6-adenine methylation is an inherent process in the organization of mitochondrial genomes too.
These results suggest that the widely observed age-related decline i...
Source: Fight Aging! - October 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
In Search of Mammalian Gene Duplications Correlated with Species Longevity
Duplication of a genetic sequence is a common occurrence over evolutionary time, one of the mechanisms by which species evolve. Noteworthy duplications include the many versions of cancer suppressor gene TP53 that are observed in the elephant genome. Large animals have many more cells than small animals, and so the evolution of greater size must be accompanied by the evolution of ways to greatly reduce cancer risk per cell.
Researchers here report on the results of searching for specific gene duplications in mammalian species that correlate with species longevity. This provides starting points for further study of t...
Source: Fight Aging! - October 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Serum Galectin-3 Correlates with Frailty Risk
In this study, we aimed to address the change of Gal-3 levels in human whole blood with frailty. We performed serum biochemical and peripheral blood mononuclear cells (PBMC) microarray analyses in humans to determine the secretory phenotype characteristics of frailty. Furthermore, we used the frail mouse model to study the significantly altered behavioral phenotype and associated secreted Gal-3 levels in blood samples to reveal the Gal-3-dependent inflammatory dysregulation of frailty. (Source: Fight Aging!)
Source: Fight Aging! - October 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Worldwide Trends in Healthy versus Unhealthy Remaining Life Expectancy at 60
Human life expectancy has been trending upwards, slowly, for a very long time. Life expectancy at birth is influenced by a great many factors that have little to do with aging, and so is much less interesting than, say, life expectancy at 60. At present, that number increases by one year with every passing decade. This has been the case in an environment in which essentially nothing was being done to deliberately target underlying mechanisms of aging. The trend is an incidental side-effect of, most likely, (a) better life-long control over the burden of infectious disease, and (b) general improvements in the ability to tre...
Source: Fight Aging! - October 20, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Combining CAR-T Therapy with Tumor-Seeking Bacteria
T cells engineered to express a chimeric antigen receptor (CAR) aggressively attack other cells bearing surface markers that match that receptor. This approach is expensive, as it requires engineering cells taken from a patient, and developing CARs specific to each cancer subtype, but has so far proven effective against a number of forms of cancer. Not all cancers are consistent in markers expressed by cancer cells, however, and many cancers exhibit rapid evolution of tumor cell characteristics - only a marginal slowing of progress is achieved when much of the cancer can quickly become immune to a therapeutic approach.
...
Source: Fight Aging! - October 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Towards Inhibition of α-Synuclein Aggregation
We report that αS1-25 inhibits lipid-induced αS aggregation in a dose-dependent manner. αS1-25 functions by binding to lipids to prevent αS binding, with both αS and peptide requiring lipid for inhibition to occur. These findings present a potential mechanistic route for the treatment or prevention of PD. (Source: Fight Aging!)
Source: Fight Aging! - October 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
