‘Now we know where the dead went.’ Did grave robbers plunder battlefields?
In the late 18th and early 19th centuries, a succession of wars ravaged Europe. Massive armies squared off and massacred each other using cannon and rifle fire and mass cavalry charges that claimed tens of thousands of casualties in hours. At the 1815 Battle of Waterloo, Napoleon Bonaparte’s final battle, more than 10,000 men and as many horses were killed in a single day. Yet today, archaeologists often struggle to find physical evidence of the dead from that bloody time period. Plowing and construction are usually the culprits behind missing historical remains, but they can’t explain the loss here. How did so many bo...
Source: Science of Aging Knowledge Environment - April 2, 2024 Category: Geriatrics Source Type: research
Cost-effectiveness of romosozumab for the treatment of postmenopausal women with osteoporosis at high risk of fracture in Belgium
ConclusionSequential treatment with romosozumab followed by alendronate was found to be cost-effective compared to alendronate monotherapy and dominant compared to teriparatide followed by alendronate for postmenopausal women with osteoporosis at high risk of fracture in Belgium. (Source: Osteoporosis International)
Source: Osteoporosis International - April 2, 2024 Category: Orthopaedics Source Type: research
Strategic learning of people ’s names as a function of expected utility in young and older adults
. (Source: Aging, Neuropsychology, and Cognition)
Source: Aging, Neuropsychology, and Cognition - March 29, 2024 Category: Geriatrics Authors: Christel DevueMarie BadolleSerge Br édartPsychology and Neuroscience of Cognition Research Unit, University of Liège, Liège, Belgium Source Type: research
GSE196788 Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk promoting immunosuppression and immunotherapy resistance [RNAseq_Panc02_sgNT_sgCda_tumor]
Contributor : Massimiliano MazzoneSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Here we use Here, we used RNA sequencing to identify trascriptictomic profile of sgNT and sgCda PancO2 tumor bearing-mice.Methods: 4x10e6 sgNT and sgCda Panc02 cells were injected subcutaneously (s.c.) in the right flank of the C57BL/6J mouse in a final suspension of 200 μL PBS. Tumor volumes were measured at least three times per week. At day 16 after injection, tumor-bearing mice were sacrificed by cervical dislocation and RNA was isolated from tumor tissue using TRIzol (Life Technologies). ...
Source: GEO: Gene Expression Omnibus - March 28, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE196787 Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk promoting immunosuppression and immunotherapy resistance [RNAseq_Panc02_sgNT_sgCda_invitro]
Contributor : Massimiliano MazzoneSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: To study the effects of CDA depletion on PancO2 cell line. Here, we used RNA sequencing to understand if sgCda can alter cancer cell immunogenicity by looking at mutational burden.Methods: PancO2 cancer cells were transduced with a doxycycline-inducible Cas9 nuclease (Edit-R Inducible Lentiviral Cas9, Dharmacom) and selected with blasticidin (Bio-Connect). Cells expressing the doxycycline-inducible Cas9 nuclease were transduced with a target specific gRNA for CDA and a control non-targeting NT...
Source: GEO: Gene Expression Omnibus - March 28, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Conducting a national RT-QI project – challenges and opportunities
This article delineates the evolution and results of the Belgian national project dedicated to radiotherapy-specific QIs while also exploring the challenges and opportunities inherent in implementing such a multi-centric initiative. (Source: Clinical Oncology)
Source: Clinical Oncology - March 28, 2024 Category: Radiology Authors: Aude Vaandering, Yolande Lievens, the Belgian College for Physicians in Radiation Oncology Source Type: research
Clinician perspectives on policy approaches to genetic risk disclosure in families
In this study, we conducted semi-structured interviews with clinicians from Belgian clinical genetics centers to gain insight into their perspectives on policy approaches to the disclosure of genetic risk within families. Using real-world examples of legislation and court rulings from France, Australia, and the UK, we explored clinician viewpoints on the roles and responsibilities of both patients and clinicians in the family communication process. Clinicians expressed confusion regarding what was legally permissible regarding contacting at-risk relatives. While there was a consensus among participants that patients have a...
Source: Familial Cancer - March 28, 2024 Category: Cancer & Oncology Source Type: research
Is There a Gender Gap in the Birthday-Number Effect? The Case of Lotto Players and the Role of Sequential Choice
AbstractThe literature on lottery gambling shows that players do not select numbers randomly, a phenomenon which is called conscious selection. Mainly, players prefer “small” numbers (less than thirty), either because of the existence of small lucky numbers or because they are victims of the so-called birthday-number effect. Because lotto games are parimutuel, such preferences result in poor ticket choices in terms of achieving below average returns. Using da ta from Belgium, where approximately 10% of the population plays lotto games every week, this paper extends prior literature by documenting the existence of a gen...
Source: Journal of Gambling Studies - March 27, 2024 Category: Addiction Source Type: research
Sensors, Vol. 24, Pages 2108: Spatially Explicit Active Learning for Crop-Type Mapping from Satellite Image Time Series
ijker
The availability of a sufficient number of annotated samples is one of the main challenges of the supervised methods used to classify crop types from remote sensing images. Creating these samples is time-consuming and costly. Active Learning (AL) offers a solution by streamlining sample annotation, resulting in more efficient training with less effort. Unfortunately, most of the developed AL methods overlook spatial information inherent in remote sensing images. We propose a novel spatially explicit AL that uses the semi-variogram to identify and discard redundant, spatially adjacent samples. It was evaluated usi...
Source: Sensors - March 26, 2024 Category: Biotechnology Authors: Beatrice Kaijage Mariana Belgiu Wietske Bijker Tags: Article Source Type: research
Viruses, Vol. 16, Pages 504: Sequences Related to Chimay Rhabdovirus Are Widely Distributed in Ixodes ricinus Ticks across England and Wales
holas Johnson
Ticks are the main arthropod vector of pathogens to humans and livestock in the British Isles. Despite their role as a vector of disease, many aspects of tick biology, ecology, and microbial association are poorly understood. To address this, we investigated the composition of the microbiome of adult and nymphal Ixodes ricinus ticks. The ticks were collected on a dairy farm in Southwest England and RNA extracted for whole genome sequencing. Sequences were detected from a range of microorganisms, particularly tick-associated viruses, bacteria, and nematodes. A majority of the viruses were attributed to phl...
Source: Viruses - March 26, 2024 Category: Virology Authors: Mirjam Schilling Megan Golding Ben P. Jones Karen L. Mansfield Sara Gandy Jolyon Medlock Nicholas Johnson Tags: Brief Report Source Type: research
Precarious employment and mental health in the Belgian service voucher system: the role of working conditions and perceived financial strain
ConclusionThese findings are the first based on the Belgian Employment Precariousness Scale (EPRES-BE) and are consistent with earlier-made —but seldom simultaneously tested—assumptions on the mechanisms relating PE to adverse mental health—i.e. involving direct associations and indirect associations via adverse working conditions and material deprivation. Based on the results, we recommend more democratic and higher-quality manag ement practices in the SVS, in addition to higher wages and working time reduction. (Source: International Archives of Occupational and Environmental Health)
Source: International Archives of Occupational and Environmental Health - March 26, 2024 Category: Occupational Health Source Type: research
Lot-to-lot consistency, immunogenicity, and safety of the Ad26.ZEBOV, MVA-BN-Filo Ebola virus vaccine regimen: A phase 3, randomized, double-blind, placebo-controlled trial
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - March 25, 2024 Category: Allergy & Immunology Authors: Neil GoldsteinChelsea McLeanAuguste GaddahJoachim DouaBabajide KeshinroLinda Bus-JacobsJenny HendriksKerstin LuhnCynthia RobinsonMacaya Douoguiha Janssen Vaccines & Prevention B.V, Leiden, The Netherlandsb Janssen Research & Development, Beerse, Belgium Source Type: research
Adherence and Persistence to Basal Insulin Among People with Type 2 Diabetes in Europe: A Systematic Literature Review and Meta-analysis
ConclusionThe results highlight that almost half of patients with T2D in Western Europe have poor adherence to insulin therapy and, at 18 months, one in three patients do not persist on treatment. These findings call for new basal insulin therapies and diabetes management strategies that can improve treatment persistence and adherence among people with T2D. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 23, 2024 Category: Endocrinology Source Type: research
