The Gut Microbiome Becomes More Uniquely Dysfunctional with Age from Individual to Individual
The gut microbiome changes with age, and these changes are implicated in the progression of aging, such as via loss of beneficial metabolites produced by microbial species, or by chronic inflammation generated by harmful microbes when present in greater numbers. Researchers here add more data to what is known of the way in which the gut microbiome changes over the years, showing that the diversity of the microbiome increases across a population with increasing age. Resetting the gut microbiome to a more youthful configuration has been shown to be possible in animal studies via fecal microbiota transplantation from young in...
Source: Fight Aging! - February 24, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 17th 2020
In this study, we sought to elucidate the role of VRK-1 in regulation of adult life span in C. elegans. We found that overexpression of VRK-1::GFP (green fluorescent protein), which was detected in the nuclei of cells in multiple somatic tissues, including the intestine, increased life span. Conversely, genetic inhibition of vrk-1 decreased life span. We further showed that vrk-1 was essential for the increased life span of mitochondrial respiratory mutants. We demonstrated that VRK-1 was responsible for increasing the level of active and phosphorylated form of AMPK, thus promoting longevity.
A Fisetin Variant, C...
Source: Fight Aging! - August 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Gut Microbiome Changes Shortly Before Death in Centenarians
The objective was to explore the dynamic changes of gut microbiota in healthy centenarians and centenarians approaching end of life and to unravel the characteristics of aging-associated microbiome. Seventy-five healthy centenarians participated in follow-up surveys and collection of fecal samples at intervals of 3 months. Data pertaining to dietary status, health status scores, cause of disease and death, and fecal specimens were collected for 15 months.
Twenty participants died within 20 months during the follow-up period. The median survival time was 8-9 months and the mortality rate was 14.7% per year. The healt...
Source: Fight Aging! - August 11, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 16th 2019
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - December 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Calorie Restriction as a Way to Slow Harmful Age-Related Changes in the Gut Microbiome
In this study, we investigated the effect of long-term 30% CR compared with ad libitum (AL) feeding on the microbiome in aging. We studied the Tg2576 model, where a mutant variant of the human APP is expressed in transgenic mice. This transgene results in cerebral amyloid accumulation, synaptic loss, and cognitive impairment by 12 months of age. We found that female Tg2576 mice have more substantial age-related microbiome changes compared to wildtype (WT) mice, including an increase in Bacteroides, which were normalized by CR. Specific gut microbiota changes were linked to Aβ levels, with greater effects in females than i...
Source: Fight Aging! - December 10, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Mucous: Gooey, slimy . . . and necessary
You probably don’t think too often about the mucous lining of your gastrointestinal tract, this mix of proteins and polysaccharides that provides a barrier between the gastrointestinal lining and gastrointestinal contents.
Without it, however, and you would not survive for long. Inflammation, infection, and dysbiosis would proceed unchecked and you would promptly die. Mice bred to not produce mucous die within weeks. The gastrointestinal lining is therefore a vigorous producer of mucous that not only provides protection against pathogens, potential toxins, and foods as they are digested, but also otherwise highly tox...
Source: Wheat Belly Blog - October 4, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open Source Type: blogs
Towards a Biomarker of Aging Based on the Gut Microbiome
A low-cost, low-effort way to accurately assess biological age, meaning the burden of molecular damage and the countless harmful cellular reactions to that damage, would greatly speed development of rejuvenation therapies. Ideally researchers would be able to apply a therapy and then within a month obtain a measure of how greatly it affects aging. At present the only reliable way to fully assess means of slowing or reversing aging is to run life span studies, which are slow and expensive in mice, and simply not feasible in humans.
Thus a fair amount of effort is presently devoted to the development of biomarkers and...
Source: Fight Aging! - January 2, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
No Microbiome Santa Claus we cannot magically convert correlative studies into causal ones. And scientists dishing out medical advice about vaping based on such bad science is ridiculous.
Conclusions. In summary, we found that tobacco smokingsignificantly alters the bacterial profiles in feces, buccal, and saliva samples.Nooooooooooooooooo. Nooooooo. No.So - you might ask -- why does this matter? This is just a little bit of a word choice issue right? Wrong. The press release and the paper mislead as to what was found here. You might then say "so what - what does it matter?". Well, it does matter because when you make these types of misleading statements they might get picked up by the press or the public. Like in the examples below:Daily Mail:An incentive to switch to e-cigare...
Source: The Tree of Life - April 30, 2018 Category: Microbiology Authors: Jonathan Eisen Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Further Investigations of the Bacterial Contribution to Aging
In conclusion, these data indicate that the gut microbiota from old mice contributes to inflammaging after transfer to young GF mice. (Source: Fight Aging!)
Source: Fight Aging! - November 3, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Seal Finger in Canada
A recent case of “seal finger” in Canada complements an increasing number of zoonotic bacterial diseases associated with animal bites.
The following list is extracted from Gideon www.GideonOnline.com (primary references available on request) :
Bacteroides pyogenes – case of bacteremia following a cat bite.
Bacteroides tectus – cat bites
Bergeyella zoohelcum – dog-bite infection
Bisgaard’s taxon 16 – animal bite wounds
Canibacter oris – dog-bite infection
Capnocytophaga canimorsus – dog-bite infection
Capnocytophaga cynodegmi – dog-bite infec...
Source: GIDEON blog - May 26, 2017 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: General Source Type: blogs
Intestinal dysbiosis in ME/CFS patients
The microbes that live on and in us provide a host of functions that are essential for our health. Changes in the composition of these microbial communities correlate with a variety of disease states. Results of a new study (link) reveal altered populations of intestinal bacteria and metabolic disturbances in ME/CFS patients.
The study subjects were 50 patients with ME/CFS from four sites across the US (meeting 1994 CDC Fukuda and 2003 Canadian consensus criteria) and 50 healthy controls. Some of the ME/CFS patients (21/50) reported a diagnosis of inflammatory bowel syndrome, absent in all the controls. Whether IBS leads ...
Source: virology blog - April 28, 2017 Category: Virology Authors: Vincent Racaniello Tags: Commentary Information chronic fatigue syndrome dysbiosis fecal bacteria fecal microbiome mecfs metabolome myalgic encephalomyelitis Source Type: blogs
10 Ways to Cultivate Good Gut Bacteria and Reduce Depression
In this study published in the journal Neuroscience, the performance of mice on various tests of mental and physical function began to drop just four weeks after being fed a diet high in fat and sugar. Monosaccharides, the simplest carbohydrates containing a single molecule of glucose and fructose (a piece of Wonder bread), disrupt a healthy microbial balance because they are digested very easily by us and absorbed into our small intestine without any help from our microbes. That leaves our gut bugs hungry, with nothing to munch on, so they begin nibbling on the mucus lining of our intestines, which is meant to be a stro...
Source: World of Psychology - August 9, 2016 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Alternative and Nutritional Supplements Books Depression Mental Health and Wellness Personal Research Alcohol Caffeine Diet gut bacteria Gut flora Lactobacillus leaky gut Monosaccharides Probiotic sugar Source Type: blogs
Connection between genes that make cells deaf to messages from good gut bacteria and OMVs identified
(Medical Xpress)—A team of experts from several instantiations in the U. S. has found a connection in between two defective genes in humans and the messages that are sent from the type of good bacteria and Irritable Bowel Syndrone (IBS). In their document published in the journal Science, the particular team describes their studies with mice, isolated human cells and also a type of bacteria found in the human gut called Bacteroides fragilis.
Related Posts:Important advance in the fight against skin cancerProtein from bacteria alleviates food allergic reactionsAlzheimer’s disease markers could be identified via&hell...
Source: My Irritable Bowel Syndrome Story - May 6, 2016 Category: Gastroenterology Authors: Ken Tags: IBS News Source Type: blogs
Cool Images: A Halloween-Inspired Cell Collection
As Halloween approaches, we turned up some spectral images from our gallery. The collection below highlights some spooky-sounding—but really important—biological topics that researchers are actively investigating to spur advances in medicine.
Cell Skeleton
The cell skeleton, or cytoskeleton, is the framework that gives a cell its shape, helps it move and keeps its contents organized for proper function. A cell that lacks a cytoskeleton becomes misshapen and immobile. This fibroblast, a cell that normally makes connective tissues and travels to the site of a wound to help it heal, is lacking a cytoskeleton. Researche...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 29, 2015 Category: Research Authors: Srivalli Subbaramaiah Tags: Cell Biology Genetics Bacteria Cells Cellular Processes Cool Images Source Type: blogs
