Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection
ConclusionsIn this large prospective study in the US primary and urgent care setting, antibiotics had no measurable impact on the severity or duration of cough due to acute LRTI. Patients had unrealistic expectations regarding the duration of LRTI and the effect of antibiotics which should be the target of antibiotic stewardship efforts. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 15, 2024 Category: Internal Medicine Source Type: research
A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses
Infect Genet Evol. 2024 Apr 9:105591. doi: 10.1016/j.meegid.2024.105591. Online ahead of print.ABSTRACTSepsis and multidrug resistance comprise a complex of factors attributable to mortality among intensive care unit (ICU) patients globally. Pathogens implicated in sepsis are diverse, and their virulence and drug resistance remain elusive. From a tertiary care hospital ICU in Uganda, we isolated a Citrobacter freundii strain RSM030 from a patient with sepsis and phenotypically tested it against a panel of 16 antibiotics including imipenem levofloxacin, cotrimoxazole and colistin, among others. We sequenced the organism's g...
Source: Infection, Genetics and Evolution - April 11, 2024 Category: Genetics & Stem Cells Authors: Reuben S Maghembe Maximilian A K Magulye Emmanuel Eilu Simon Sekyanzi Abdalah Makaranga Savannah Mwesigwa Eric Katagirya Source Type: research
A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses
Infect Genet Evol. 2024 Apr 9:105591. doi: 10.1016/j.meegid.2024.105591. Online ahead of print.ABSTRACTSepsis and multidrug resistance comprise a complex of factors attributable to mortality among intensive care unit (ICU) patients globally. Pathogens implicated in sepsis are diverse, and their virulence and drug resistance remain elusive. From a tertiary care hospital ICU in Uganda, we isolated a Citrobacter freundii strain RSM030 from a patient with sepsis and phenotypically tested it against a panel of 16 antibiotics including imipenem levofloxacin, cotrimoxazole and colistin, among others. We sequenced the organism's g...
Source: Infection, Genetics and Evolution - April 11, 2024 Category: Genetics & Stem Cells Authors: Reuben S Maghembe Maximilian A K Magulye Emmanuel Eilu Simon Sekyanzi Abdalah Makaranga Savannah Mwesigwa Eric Katagirya Source Type: research
A Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacter hormaechei Strain from Mixed Sprouts
Curr Microbiol. 2024 Apr 9;81(5):131. doi: 10.1007/s00284-024-03663-3.ABSTRACTFresh vegetables can harbor antibiotic-resistant bacteria, including extended-spectrum β-lactamase (ESBL)-producing Enterobacterales. Enterobacter hormaechei is a bacterium belonging to the Enterobacterales order and the most commonly identified nosocomial pathogen of Enterobacter cloacae complex. The purpose of this study was to characterize a multi-drug resistant ESBL-producing E. hormaechei strain isolated from a sample of mixed sprouts. Vegetable samples were pre-enriched in buffered peptone water, followed by enrichment in Enterobacteria En...
Source: Current Microbiology - April 9, 2024 Category: Microbiology Authors: Elizabeth A Leighton Chelsea N Gale En Huang Xu Yang Erin L DiCaprio Xinhui Li Source Type: research
Amoxicillin/clavulanate in combination with rifampicin/clarithromycin is bactericidal against < i > Mycobacterium ulcerans < /i >
Conclusions/SignificanceOur study suggests that alternative and faster TKA methodologies can be used in BU research instead of the cumbersome CFU quantification method. These results provide anin vitro microbiological support to of the BLMs4BU clinical trial (NCT05169554,PACTR202209521256638) to shorten BU treatment. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 4, 2024 Category: Tropical Medicine Authors: Emma S áez-López Source Type: research
Characterization of Weissella Species during a 3-Year Observational Study - An Emerging Threat
In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four-hour growth from a positive blood culture or CSF sample was identified by matri...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Ashima Jamwal Gerlin Varghese Deepika Sarawat Nidhi Tejan Sangram Singh Patel Chinmoy Sahu Source Type: research
Characterization of Weissella Species during a 3-Year Observational Study - An Emerging Threat
In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four-hour growth from a positive blood culture or CSF sample was identified by matri...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Ashima Jamwal Gerlin Varghese Deepika Sarawat Nidhi Tejan Sangram Singh Patel Chinmoy Sahu Source Type: research
Characterization of Weissella Species during a 3-Year Observational Study - An Emerging Threat
In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four-hour growth from a positive blood culture or CSF sample was identified by matri...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Ashima Jamwal Gerlin Varghese Deepika Sarawat Nidhi Tejan Sangram Singh Patel Chinmoy Sahu Source Type: research
Characterization of Weissella Species during a 3-Year Observational Study - An Emerging Threat
In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four-hour growth from a positive blood culture or CSF sample was identified by matri...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Ashima Jamwal Gerlin Varghese Deepika Sarawat Nidhi Tejan Sangram Singh Patel Chinmoy Sahu Source Type: research
Characterization of Weissella Species during a 3-Year Observational Study - An Emerging Threat
In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four-hour growth from a positive blood culture or CSF sample was identified by matri...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Ashima Jamwal Gerlin Varghese Deepika Sarawat Nidhi Tejan Sangram Singh Patel Chinmoy Sahu Source Type: research
Characterization of Weissella Species during a 3-Year Observational Study - An Emerging Threat
In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four-hour growth from a positive blood culture or CSF sample was identified by matri...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Ashima Jamwal Gerlin Varghese Deepika Sarawat Nidhi Tejan Sangram Singh Patel Chinmoy Sahu Source Type: research
Characterization of Weissella Species during a 3-Year Observational Study - An Emerging Threat
In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four-hour growth from a positive blood culture or CSF sample was identified by matri...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Ashima Jamwal Gerlin Varghese Deepika Sarawat Nidhi Tejan Sangram Singh Patel Chinmoy Sahu Source Type: research
Characterization of Weissella Species during a 3-Year Observational Study - An Emerging Threat
In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four-hour growth from a positive blood culture or CSF sample was identified by matri...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Ashima Jamwal Gerlin Varghese Deepika Sarawat Nidhi Tejan Sangram Singh Patel Chinmoy Sahu Source Type: research
Characterization of Weissella Species during a 3-Year Observational Study - An Emerging Threat
In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four-hour growth from a positive blood culture or CSF sample was identified by matri...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Ashima Jamwal Gerlin Varghese Deepika Sarawat Nidhi Tejan Sangram Singh Patel Chinmoy Sahu Source Type: research
Characterization of Weissella Species during a 3-Year Observational Study - An Emerging Threat
In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four-hour growth from a positive blood culture or CSF sample was identified by matri...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Ashima Jamwal Gerlin Varghese Deepika Sarawat Nidhi Tejan Sangram Singh Patel Chinmoy Sahu Source Type: research
