Metagenomics assists in the diagnosis of a refractory, culture-negative pyoderma gangrenosum-like ulcer caused by Helicobacter cinaedi in a patient with primary agammaglobulinemia
We reported a refractory and culture-negative pyoderma gangrenosum-like ulcer caused by H. cinaedi in a patient with primary agammaglobulinemia. Metagenomic next-generation sequencing (mNGS) was applied for the identification of H. cinaedi and prolonged minocycline and amoxicillin-clavulanate potassium was used to eradicate the infection. Given the difficulties in culturing this organism, it's highly possible that H cinaedi infections have been overlooked. We suggest that early consideration of H. cinaedi infection should be suspected in immunocompromised patients presenting with unexplained skin lesions as the appropriate...
Source: Journal of Microbiology, Immunology, and Infection - July 31, 2023 Category: Microbiology Authors: Li Zhang Menglan Zhou Wei Lv Taisheng Li Yingchun Xu Zhengyin Liu Source Type: research
Metagenomics assists in the diagnosis of a refractory, culture-negative pyoderma gangrenosum-like ulcer caused by Helicobacter cinaedi in a patient with primary agammaglobulinemia
We reported a refractory and culture-negative pyoderma gangrenosum-like ulcer caused by H. cinaedi in a patient with primary agammaglobulinemia. Metagenomic next-generation sequencing (mNGS) was applied for the identification of H. cinaedi and prolonged minocycline and amoxicillin-clavulanate potassium was used to eradicate the infection. Given the difficulties in culturing this organism, it's highly possible that H cinaedi infections have been overlooked. We suggest that early consideration of H. cinaedi infection should be suspected in immunocompromised patients presenting with unexplained skin lesions as the appropriate...
Source: Journal of Microbiology, Immunology, and Infection - July 31, 2023 Category: Microbiology Authors: Li Zhang Menglan Zhou Wei Lv Taisheng Li Yingchun Xu Zhengyin Liu Source Type: research
Metagenomics assists in the diagnosis of a refractory, culture-negative pyoderma gangrenosum-like ulcer caused by Helicobacter cinaedi in a patient with primary agammaglobulinemia
We reported a refractory and culture-negative pyoderma gangrenosum-like ulcer caused by H. cinaedi in a patient with primary agammaglobulinemia. Metagenomic next-generation sequencing (mNGS) was applied for the identification of H. cinaedi and prolonged minocycline and amoxicillin-clavulanate potassium was used to eradicate the infection. Given the difficulties in culturing this organism, it's highly possible that H cinaedi infections have been overlooked. We suggest that early consideration of H. cinaedi infection should be suspected in immunocompromised patients presenting with unexplained skin lesions as the appropriate...
Source: Journal of Microbiology, Immunology, and Infection - July 31, 2023 Category: Microbiology Authors: Li Zhang Menglan Zhou Wei Lv Taisheng Li Yingchun Xu Zhengyin Liu Source Type: research
Antibiotics vs Placebo for Acute Sinusitis in Children
This randomized clinical trial compares the effect of amoxicillin and clavulanate vs placebo on symptom burden in children diagnosed with acute sinusitis. (Source: JAMA)
Source: JAMA - July 25, 2023 Category: General Medicine Source Type: research
Time for Acute Bacterial Rhinosinusitis Point-of-Care Testing
The diagnosis of acute bacterial rhinosinusitis in children is clinically challenging due to symptom overlap with acute viral upper respiratory illnesses. To help address this frequent conundrum, Shaikh and colleagues designed a study to identify children who are likely to benefit from antibiotics for acute rhinosinusitis. The investigators included 510 children (2-11 years old) who met inclusion criteria to receive amoxicillin, 90 mg/kg/d, and clavulanate, 6.4 mg/kg/d, or placebo, then further stratified the patients based on nasopharyngeal culture for Streptococcus pneumoniae, nontypeable Haemophilus influenzae, or Morax...
Source: JAMA Otolaryngology - Head and Neck Surgery - July 25, 2023 Category: ENT & OMF Source Type: research
Women of Childbearing Age With Hidradenitis Suppurativa Frequently Prescribed Medications With Pregnancy Risk
DISCUSSION: Nearly a third of women of childbearing age with HS are receiving medications considered teratogenic. As many female patients feel that their physicians are not counseling them regarding the impact of HS therapy on childbearing, the results of this study serve as a reminder to dermatologists and non-dermatologists managing skin disease to continue to facilitate conversations about potential pregnancy risk when prescribing medications with pregnancy risk. Peck G, Fleischer AB Jr. Women of childbearing age with hidradenitis suppurativa frequently prescribed medications with pregnancy risk. J Drugs Dermatol. 2023;...
Source: Journal of Drugs in Dermatology - July 6, 2023 Category: Dermatology Authors: Gabrielle Marie Rivin Alan B Fleischer Source Type: research
