Switching from efavirenz to rilpivirine improves sleep quality and self-perceived cognition but has no impact on neurocognitive performances
Conclusion:
Our results do not support the hypothesis that switching to RPV improves cognitive function in patient under stable treatment with EFV. Nonetheless, improvements in neuropsychiatric symptoms, sleep quality and self-perceived cognition were observed. (Source: AIDS)
Source: AIDS - December 3, 2019 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Effects of Highly Active Antiretroviral Therapy on Albuminuria in HIV-infected Persons.
CONCLUSIONS: HIV induces renal impairment. Thus, albuminuria, microalbuminuria and nonalbuminuric renal insufficiency are highly prevalent in antiretroviral-naïve HIV-infected persons but nephrotic-range albuminuria is uncommon. Albuminuria and/microalbuminuria and eGFR improve concurrently on HAART (with/without tenofovir DF). Zidovudine-based HAART (ZDV/3TC/NVP) resolves microalbuminuria earlier, and without relapse, unlike Tenovofir-based regimen and zidovudine with efavirenz (ZDV/3TC/EFV).
PMID: 31389318 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - August 6, 2019 Category: Infectious Diseases Authors: Adedeji TA, Adebisi SA, Adedeji NO Tags: Infect Disord Drug Targets Source Type: research
Effects of Long-term Exposure to Tenofovir Disoproxil Fumarate-Containing Antiretroviral Therapy on Renal Function in HIV-Positive Chinese Patients
ConclusionsTDF-related renal impairment remained rare in HIV-positive Chinese patients with a median age of 29 years who had no comorbidities. A lower weight and duration of ART were associated with decreased renal function. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - August 6, 2019 Category: Microbiology Source Type: research
Assessing the lymphoid tissue bioavailability of antiretrovirals in human primary lymphoid endothelial cells and in mice
ConclusionsARVs displayed distinct HLEC penetration patterns. PK studies of representative ARVs in LT of mice were concordant with HLEC bioavailability. These findings support further development of this approach and its translational predictability in humans. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - July 23, 2019 Category: Microbiology Source Type: research
Switching at Low HIV-1 RNA into Fixed Dose Combinations: TDF/FTC/RPV is non-inferior to TDF/FTC/EFV in first-line suppressed patients living with HIV
Conclusion: In adults with suppressed viral load on first-line NNRTI-based ART in LMICs, switching to an STR of TDF/FTC/RPV was non-inferior to TDF/FTC/EFV in maintaining high rates of viral suppression with a comparable tolerability profile. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - July 22, 2019 Category: African Health Authors: Paula Munderi Source Type: research
Nature and prevalence of adverse drug reaction of antiretroviral medications in Halibet National Referral Hospital: a retrospective study.
CONCLUSION: ADRs associated with ART drugs in Halibet hospital were found to be highly prevalent. Furthermore, CD4 count below 200, was identified as a major risk factor that predisposes patients to ADRs. This is burdensome to resource constrained countries such as Eritrea who have limited drug options and high HIV prevalence, therefore these findings will help patients and healthcare professionals understand the nature as well as seriousness of these ADRs and identify the risks involved with ART medications which can help minimize ART associated ADRs early on.
PMID: 31060603 [PubMed - in process] (Source: BMC Phar...
Source: BMC Pharmacology and Toxicology - May 8, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Effects on immune system and viral reservoir of a short-cycle antiretroviral therapy in virologically suppressed HIV-positive patients
Conclusion:
No significant immunological or viral changes were induced in the 3W group confirming the virological efficacy and immunogical safety of this strategy. In-depth virological and immunological analyses are useful in providing additional information in antiretroviral switching studies (Clinical Trials.gov: NCT01778413). (Source: AIDS)
Source: AIDS - April 6, 2019 Category: Infectious Diseases Tags: BASIC SCIENCE Source Type: research
Randomized clinical trial on efficacy of fixed-dose efavirenz/tenofovir/emtricitabine on alternate days versus continuous treatment
The objective of this study was to investigate the noninferiority of the TDF/FTC/EFV fixed-dose combination on alternate-days versus standard regimen in virologically suppressed patients.
Design:
A randomized-controlled open-label noninferiority trial enrolling HIV-1-infected patients treated for at least 6 months with TDF/FTC/EFV fixed-dose combination, virologically suppressed ( (Source: AIDS)
Source: AIDS - February 1, 2019 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Race/Ethnicity and Protease Inhibitor Use Influence Plasma Tenofovir Exposure in Adults Living with HIV-1 in AIDS Clinical Trials Group Study A5202.
Conclusion Race/ethnicity is associated with tenofovir oral CL in HIV-1 positive, treatment-naïve adults. This covariate relationship raises questions about the possibility of differences in efficacy and risk of adverse events in different patient populations, and suggests that examining pre-exposure prophylaxis regimens and TFV exposure in different race/ethnicity groups be considered.
PMID: 30642925 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - January 14, 2019 Category: Microbiology Authors: Bednasz CJ, Venuto CS, Ma Q, Daar ES, Sax PE, Fischl M, Collier AC, Smith KY, Tierney C, Acosta EP, Mager DE, Morse GD, AIDS Clinical Trials Group Study A5202 Team Tags: Antimicrob Agents Chemother Source Type: research
Stability behaviour of antiretroviral drugs and their combinations. 9: Identification of incompatible excipients
Publication date: Available online 8 January 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Moolchand Kurmi, Archana Sahu, Mayurbhai Kathadbhai Ladumor, Arvind Kumar Bansal, Saranjit SinghAbstractIncompatibility studies of antiretroviral drugs, viz., lamivudine (3TC), emtricitabine (FTC), abacavir sulfate (ABC), tenofovir disoproxil fumarate (TDF), zidovudine (ZDV), efavirenz (EFV) and nevirapine (NVP) were carried out in the presence of ten selected excipients, i.e., microcrystalline cellulose, lactose monohydrate, starch, magnesium stearate, sodium lauryl sulfate, sodium starch glycolate, croscar...
Source: Journal of Pharmaceutical and Biomedical Analysis - January 9, 2019 Category: Drugs & Pharmacology Source Type: research
Symfi, Symfi Lo, and Cimduo for HIV (online only)
Date: January 14, 2019
Issue #:
1563Summary:
The FDA has approved three new once-daily fixed-dose
antiretroviral drug combinations for treatment of HIV-1 infection.Symfi andSymfi Lo (Mylan) contain the
non-nucleoside reverse transcriptase inhibitor (NNRTI)
efavirenz and the nucleoside reverse transcriptase
inhibitors (NRTIs) lamivudine and tenofovir disoproxil
fumarate (TDF) and were approved as complete
antiretroviral regimens.Symfi Lo contains a lower
dose of efavirenz than bothSymfi andAtripla, a fixed-dose
combination of efavirenz, TDF, and the NRTI
emtricitabine that was app...
Source: The Medical Letter - January 3, 2019 Category: Drugs & Pharmacology Authors: admin Source Type: research
Objective and Subjective Improvement of Cognition After Discontinuing Efavirenz in Asymptomatic Patients: A Randomized Controlled Trial
Conclusions:
Switching from Atripla to Eviplera resulted in objective cognitive improvement on the group level in cognitively asymptomatic patients. Discrepancies in objective and subjective cognitive complaints make it challenging to identify patients who would benefit from discontinuing efavirenz. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - December 11, 2018 Category: Infectious Diseases Tags: Clinical Science Source Type: research
Pharmacokinetic (PK) interaction of fixed-dose combination (FDC) antiretrovirals (ARV) with riociguat (rio)
Conclusion: Rio exposure, when co-administered with ARV regimens, ranged from no apparent change with ATR to an approx. 3-fold increase with TMQ. In pts on stable FDC ARVs rio should be initiated at 0.5mg tid and pts monitored for signs and symptoms of hypotension at initiation and on treatment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Dejesus, E., Saleh, S., Van Der Mey, D., Becker, C., Frey, R., Unger, S., Mueck, W. Tags: Pulmonary hypertension Source Type: research
Switching to coformulated rilpivirine (RPV), emtricitabine (FTC) and tenofovir alafenamide from either RPV, FTC and tenofovir disoproxil fumarate (TDF) or efavirenz, FTC and TDF: 96 ‐week results from two randomized clinical trials
HIV Medicine, EarlyView. (Source: HIV Medicine)
Source: HIV Medicine - August 13, 2018 Category: Infectious Diseases Authors: D Hagins
,
C Orkin
,
ES Daar
,
A Mills
,
C Brinson
,
E DeJesus
,
FA Post
,
J Morales ‐Ramirez
,
M Thompson
,
O Osiyemi
,
B Rashbaum
,
H‐J Stellbrink
,
C Martorell
,
H Liu
,
Y‐P Liu
,
D Porter
,
SE Collins
,
D SenG Source Type: research
Prevalence and Associated Factors of Neurocognitive Impairment in HIV-Positive Patients on Effective Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate Treatment
AIDS Research and Human Retroviruses, Ahead of Print. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - July 23, 2018 Category: Infectious Diseases Authors: Maria Letizia Giancola Pietro Balestra Adriana Ammassari Martina Ricottini Patrizia Lorenzini Claudio Angeletti Rita Bellagamba Chiara Tommasi Massimo Tempestilli Mauro Zaccarelli Carmela Pinnetti Anna Loredana Gallo Andrea Antinori Pasquale Narciso Emanu Source Type: research
