Race/Ethnicity and Protease Inhibitor Use Influence Plasma Tenofovir Exposure in Adults Living with HIV-1 in AIDS Clinical Trials Group Study A5202.

Conclusion Race/ethnicity is associated with tenofovir oral CL in HIV-1 positive, treatment-naïve adults. This covariate relationship raises questions about the possibility of differences in efficacy and risk of adverse events in different patient populations, and suggests that examining pre-exposure prophylaxis regimens and TFV exposure in different race/ethnicity groups be considered.
PMID: 30642925 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - January 14, 2019 Category: Microbiology Authors: Bednasz CJ, Venuto CS, Ma Q, Daar ES, Sax PE, Fischl M, Collier AC, Smith KY, Tierney C, Acosta EP, Mager DE, Morse GD, AIDS Clinical Trials Group Study A5202 Team Tags: Antimicrob Agents Chemother Source Type: research