Incidence Of Adverse Events Is Higher When Heart Transplant Recipients Are On High Versus Standard Dose Statin In Combination With Cyclosporine
Heart transplant recipients receive a calcineurin inhibitor (CNI) for immunosuppression. While tacrolimus is the CNI of choice, switching to cyclosporine (CSA) may be necessary due to side effects. Treatment with a statin decreases incidence of cardiac allograft vasculopathy and mortality post-transplant. CSA interacts with statins by increasing their levels, with high intensity statins often contraindicated. Per the AHA, maximum recommended statin doses for heart transplants on CSA include atorvastatin 10 mg, pravastatin 20 mg, rosuvastatin 5 mg, and fluvastatin 40 mg. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Gabriel E. Diaz, Besher Kashlan, Cole Block, Jenna Negrelli, Michelle Fine, Joshua Newman, Mingxi D. Yu, Max Liebo Tags: 153 Source Type: research
Huatanmaitong tablet alleviate cerebral ischemic reperfusion injury with hyperlipidaemia in rats by regulating OATPs/VEGF axis
Cell Mol Biol (Noisy-le-grand). 2023 Dec 10;69(13):235-240. doi: 10.14715/cmb/2023.69.13.35.ABSTRACTStroke is the top priority pathogenesis of disability and death globally, affecting people worldwide. The presence of high levels of lipids in the blood has been confirmed as a vital factor of ischemic stroke. We aim to examine the effectiveness of Huatanmaitong tablet in hyperlipidemia rats that have experienced an ischemic stroke. We created a rat model of middle cerebral artery occlusion (MCAO) with hyperlipidemia as a basis. Following 8 weeks of high-fat diet, the model rats underwent MCAO surgery. Subsequently, the rats...
Source: Cellular and Molecular Biology - December 30, 2023 Category: Molecular Biology Authors: Shuangxi Sun Qi Wang Hongxia Chen Ruihuan Pan Source Type: research
Macrophage-targeted ultrasound nanobubbles for highly efficient sonodynamic therapy of atherosclerotic plaques by modulating M1-to-M2 polarization
CONCLUSIONS: Macrophage-targeted nanoplatform SR-A-Ce6NB-mediated SDT provides a safe, effective and preferable anti-atherogenic therapy by mediating M1-to-M2 macrophage polarization.PMID:38159431 | DOI:10.1016/j.atherosclerosis.2023.117423 (Source: Atherosclerosis)
Source: Atherosclerosis - December 30, 2023 Category: Cardiology Authors: Yueying Chen Hao Wang Juhong Pan Yuxin Guo Yugang Hu Xin Huang Yanxiang Zhou Qing Deng Qing Zhou Source Type: research
Effects of Apex Size on Dissolution Profiles in the USP II Paddle Apparatus
This study aimed to clarify how different apex vessel sizes affect the dissolution behavior of cone-forming formulations. Five apex vessels with different heights, centralities, and compendial vessels were used. The paddle rotation speed at which the coning phenomenon resolved was measured using standard particles of different densities. Three model formulations-USP prednisone tablets, atorvastatin calcium hydrate tablets, and levofloxacin fine granules-were selected, and dissolution tests were conducted at 30-100 revolutions per minute (rpm). Compared to the compendial vessels, the disappearance of standard particles at t...
Source: AAPS PharmSciTech - December 29, 2023 Category: Drugs & Pharmacology Authors: Hiroyuki Yoshida Tokio Morita Yasuhiro Abe Aoi Inagaki Naomi Tomita Ken-Ichi Izutsu Yoji Sato Source Type: research
Effects of Apex Size on Dissolution Profiles in the USP II Paddle Apparatus
This study aimed to clarify how different apex vessel sizes affect the dissolution behavior of cone-forming formulations. Five apex vessels with different heights, centralities, and compendial vessels were used. The paddle rotation speed at which the coning phenomenon resolved was measured using standard particles of different densities. Three model formulations-USP prednisone tablets, atorvastatin calcium hydrate tablets, and levofloxacin fine granules-were selected, and dissolution tests were conducted at 30-100 revolutions per minute (rpm). Compared to the compendial vessels, the disappearance of standard particles at t...
Source: AAPS PharmSciTech - December 29, 2023 Category: Drugs & Pharmacology Authors: Hiroyuki Yoshida Tokio Morita Yasuhiro Abe Aoi Inagaki Naomi Tomita Ken-Ichi Izutsu Yoji Sato Source Type: research
Development of a Microminipig Model of Atherosclerosis for the Evaluation of a HMGCR Inhibitor
CONCLUSION: A microminipig atherosclerosis model induced by HFLCD can be used in the evaluation of HMGCR inhibitors for the treatment of hypercholesterolemia and atherosclerosis.PMID:38148058 | DOI:10.21873/invivo.13415 (Source: Atherosclerosis)
Source: Atherosclerosis - December 26, 2023 Category: Cardiology Authors: Tomonobu Yamada Hiroki Kawaguchi Aki Matsuoka Kohei Akioka Naoki Miura Hiroyuki Izumi Akihide Tanimoto Source Type: research
Statin Use Reduces Radiation-Induced Stroke Risk in Advanced Nasopharyngeal Carcinoma Patients
CONCLUSIONS: Our study provides evidence supporting the beneficial effects of statin use during the CCRT period in reducing radiation-induced stroke risk among patients with advanced NPC undergoing definitive CCRT. Notably, pravastatin and atorvastatin demonstrated significant reductions in stroke occurrence. Furthermore, the findings suggest a dose-response relationship, where higher cumulative doses and greater daily dose intensity of statin use were associated with a lower risk of stroke.PMID:38142934 | DOI:10.1016/j.radonc.2023.110067 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 24, 2023 Category: Radiology Authors: Chuan-Yi Lin Chia-Lun Chang Kuan-Chou Lin Wan-Ming Chen Ben-Chang Shia Po-Hsiu Kuo Szu-Yuan Wu Source Type: research
Statin Use Reduces Radiation-Induced Stroke Risk in Advanced Nasopharyngeal Carcinoma Patients
CONCLUSIONS: Our study provides evidence supporting the beneficial effects of statin use during the CCRT period in reducing radiation-induced stroke risk among patients with advanced NPC undergoing definitive CCRT. Notably, pravastatin and atorvastatin demonstrated significant reductions in stroke occurrence. Furthermore, the findings suggest a dose-response relationship, where higher cumulative doses and greater daily dose intensity of statin use were associated with a lower risk of stroke.PMID:38142934 | DOI:10.1016/j.radonc.2023.110067 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 24, 2023 Category: Radiology Authors: Chuan-Yi Lin Chia-Lun Chang Kuan-Chou Lin Wan-Ming Chen Ben-Chang Shia Po-Hsiu Kuo Szu-Yuan Wu Source Type: research
Atorvastatin exerts dual effects of lesion regression and ovarian protection in the prevention and treatment of endometriosis
This study aimed to investigate the possible effect of atorvastatin on the ovarian endocrine function and fertility capacity in the prevention and treatment of endometriosis. Here, 5 mg/kg atorvastatin was intraperitoneally injected to the endometriosis mice once a day for consecutive fourteen days during and after the development of endometriotic implants. The results indicated that atorvastatin not only led to regression of the ectopic lesions, but also caused no discernible harm to the ovary for both the preventive and the therapeutic models. In addition, it elicited a protective effect on the ovarian reserve and fertil...
Source: European Journal of Pharmacology - December 23, 2023 Category: Drugs & Pharmacology Authors: Xian Qin Qian Wang Dongmei Xu Yixuan Sun Wandong Xu Bo Wang Zhu Yang Lijuan Hao Source Type: research
Atorvastatin exerts dual effects of lesion regression and ovarian protection in the prevention and treatment of endometriosis
This study aimed to investigate the possible effect of atorvastatin on the ovarian endocrine function and fertility capacity in the prevention and treatment of endometriosis. Here, 5 mg/kg atorvastatin was intraperitoneally injected to the endometriosis mice once a day for consecutive fourteen days during and after the development of endometriotic implants. The results indicated that atorvastatin not only led to regression of the ectopic lesions, but also caused no discernible harm to the ovary for both the preventive and the therapeutic models. In addition, it elicited a protective effect on the ovarian reserve and fertil...
Source: European Journal of Pharmacology - December 23, 2023 Category: Drugs & Pharmacology Authors: Xian Qin Qian Wang Dongmei Xu Yixuan Sun Wandong Xu Bo Wang Zhu Yang Lijuan Hao Source Type: research
Influence of a Short Course of Ritonavir Used as Booster in Antiviral Therapies Against SARS-CoV-2 on the Exposure of Atorvastatin and Rosuvastatin
ConclusionAtorvastatin doses should likely be adjusted during nirmatrelvir/ritonavir treatment. For patients on a 20-mg dose, we recommend half of the original dose. In patients taking 40 mg or more, a quarter of the dose should be taken until 2 days after discontinuation of nirmatrelvir/ritonavir. Patients receiving rosuvastatin do not need to change their treatment regimen.Trial RegistrationEudraCT number: 2021 –006634-39.DRKS00027838. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 19, 2023 Category: Cardiology Source Type: research
Differential effect of atorvastatin and pravastatin on thoracic spine attenuation: A sub-analysis of a randomized clinical trial
CONCLUSIONS: These findings support the hypothesis that there is an interaction between bone and cardiometabolic health and that intensive lipid lowering has a beneficial effect on bone health.PMID:38109819 | DOI:10.1016/j.atherosclerosis.2023.117425 (Source: Atherosclerosis)
Source: Atherosclerosis - December 18, 2023 Category: Cardiology Authors: Paolo Raggi Farzin M Takyar Varuna Gadiyaram Chao Zhang Arthur E Stillman Amir H Davarpanah Source Type: research
Comparison of the efficacy and safety of Shanhuang Jiangzhi tablets and atorvastatin in the treatment of patients with hyperlipidaemia
CONCLUSIONS: Shanhuang Jiangzhi tablets have a higher hypotriglyceridaemic performance than atorvastatin and an equivalent ability to lower TC and LDL-C. In addition, Shanhuang Jiangzhi tablets are a low-risk option for lowering blood lipids.PMID:38098069 | PMC:PMC10722779 | DOI:10.1186/s41043-023-00482-3 (Source: Journal of Health, Population, and Nutrition)
Source: Journal of Health, Population, and Nutrition - December 15, 2023 Category: International Medicine & Public Health Authors: GuoTong Sun XiuWen Liang Source Type: research
Comparison of the efficacy and safety of Shanhuang Jiangzhi tablets and atorvastatin in the treatment of patients with hyperlipidaemia
CONCLUSIONS: Shanhuang Jiangzhi tablets have a higher hypotriglyceridaemic performance than atorvastatin and an equivalent ability to lower TC and LDL-C. In addition, Shanhuang Jiangzhi tablets are a low-risk option for lowering blood lipids.PMID:38098069 | PMC:PMC10722779 | DOI:10.1186/s41043-023-00482-3 (Source: Journal of Health, Population, and Nutrition)
Source: Journal of Health, Population, and Nutrition - December 15, 2023 Category: International Medicine & Public Health Authors: GuoTong Sun XiuWen Liang Source Type: research
Comparison of the efficacy and safety of Shanhuang Jiangzhi tablets and atorvastatin in the treatment of patients with hyperlipidaemia
CONCLUSIONS: Shanhuang Jiangzhi tablets have a higher hypotriglyceridaemic performance than atorvastatin and an equivalent ability to lower TC and LDL-C. In addition, Shanhuang Jiangzhi tablets are a low-risk option for lowering blood lipids.PMID:38098069 | PMC:PMC10722779 | DOI:10.1186/s41043-023-00482-3 (Source: Journal of Health, Population, and Nutrition)
Source: Journal of Health, Population, and Nutrition - December 15, 2023 Category: International Medicine & Public Health Authors: GuoTong Sun XiuWen Liang Source Type: research
