Molecules, Vol. 27, Pages 5036: Why Ortho- and Para-Hydroxy Metabolites Can Scavenge Free Radicals That the Parent Atorvastatin Cannot? Important Pharmacologic Insight from Quantum Chemistry
The pharmaceutical success of atorvastatin (ATV), a widely employed drug against the “bad” cholesterol (LDL) and cardiovascular diseases, traces back to its ability to scavenge free radicals. Unfortunately, information on its antioxidant properties is missing or unreliable. Here, we report detailed quantum chemical results for ATV and its ortho- and para-hydroxy metabolites (o-ATV, p-ATV) in the methanolic phase. They comprise global reactivity indices, bond order indices, and spin densities as well as all relevant enthalpies of reaction (bond dissociation BDE, ionization IP and electron at...
Source: Molecules - August 8, 2022 Category: Chemistry Authors: Ioan B âldea Tags: Article Source Type: research

The role of cytokines, adhesion molecules, and toll-like receptors in atherosclerosis progression: the effect of Atorvastatin
J Med Life. 2022 Jun;15(6):751-756. doi: 10.25122/jml-2021-0187.ABSTRACTInflammatory cytokines, cell adhesion molecules, and toll-like receptors (TLRs) play an important role in atherosclerosis. The aim of this study was to further evaluate the role of inflammatory cytokines, cell adhesion molecules, and toll-like receptors in atherosclerosis. Forty local breed domestic male rabbits were divided randomly into 4 groups, 10 rabbits each. Group I was the control group, group II received a high cholesterol diet, group III received the drug solvent dimethyl sulfoxide (DMSO), and group IV received Atorvastatin (3.5 mg/kg/day). B...
Source: Atherosclerosis - August 5, 2022 Category: Cardiology Authors: Ali Saud Nabeel Aj Ali Fadil Gali Najah Hadi Source Type: research

The role of cytokines, adhesion molecules, and toll-like receptors in atherosclerosis progression: the effect of Atorvastatin
J Med Life. 2022 Jun;15(6):751-756. doi: 10.25122/jml-2021-0187.ABSTRACTInflammatory cytokines, cell adhesion molecules, and toll-like receptors (TLRs) play an important role in atherosclerosis. The aim of this study was to further evaluate the role of inflammatory cytokines, cell adhesion molecules, and toll-like receptors in atherosclerosis. Forty local breed domestic male rabbits were divided randomly into 4 groups, 10 rabbits each. Group I was the control group, group II received a high cholesterol diet, group III received the drug solvent dimethyl sulfoxide (DMSO), and group IV received Atorvastatin (3.5 mg/kg/day). B...
Source: Journal of Medicine and Life - August 5, 2022 Category: General Medicine Authors: Ali Saud Nabeel Aj Ali Fadil Gali Najah Hadi Source Type: research

The role of cytokines, adhesion molecules, and toll-like receptors in atherosclerosis progression: the effect of Atorvastatin
J Med Life. 2022 Jun;15(6):751-756. doi: 10.25122/jml-2021-0187.ABSTRACTInflammatory cytokines, cell adhesion molecules, and toll-like receptors (TLRs) play an important role in atherosclerosis. The aim of this study was to further evaluate the role of inflammatory cytokines, cell adhesion molecules, and toll-like receptors in atherosclerosis. Forty local breed domestic male rabbits were divided randomly into 4 groups, 10 rabbits each. Group I was the control group, group II received a high cholesterol diet, group III received the drug solvent dimethyl sulfoxide (DMSO), and group IV received Atorvastatin (3.5 mg/kg/day). B...
Source: Atherosclerosis - August 5, 2022 Category: Cardiology Authors: Ali Saud Nabeel Aj Ali Fadil Gali Najah Hadi Source Type: research

The role of cytokines, adhesion molecules, and toll-like receptors in atherosclerosis progression: the effect of Atorvastatin
J Med Life. 2022 Jun;15(6):751-756. doi: 10.25122/jml-2021-0187.ABSTRACTInflammatory cytokines, cell adhesion molecules, and toll-like receptors (TLRs) play an important role in atherosclerosis. The aim of this study was to further evaluate the role of inflammatory cytokines, cell adhesion molecules, and toll-like receptors in atherosclerosis. Forty local breed domestic male rabbits were divided randomly into 4 groups, 10 rabbits each. Group I was the control group, group II received a high cholesterol diet, group III received the drug solvent dimethyl sulfoxide (DMSO), and group IV received Atorvastatin (3.5 mg/kg/day). B...
Source: Journal of Medicine and Life - August 5, 2022 Category: General Medicine Authors: Ali Saud Nabeel Aj Ali Fadil Gali Najah Hadi Source Type: research

Identification of target and pathway of aspirin combined with Lipitor treatment in prostate cancer through integrated bioinformatics analysis
CONCLUSION: The enrichment pathways and targets of Lipitor combined with aspirin in PCa are discovered, and DSCC1 silencing can potentiate the effect of Lipitor combined with aspirin in the treatment of PCa.PMID:35926565 | DOI:10.1016/j.taap.2022.116169 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - August 4, 2022 Category: Toxicology Authors: Xiao Wang Yi Wu Junlei Liu Xuetao Xu Zhaojun Sheng Wenfeng Liu Min Chen Yanyan Ma Denggao Zhao Dongli Li Xi Zheng Source Type: research

Identification of target and pathway of aspirin combined with Lipitor treatment in prostate cancer through integrated bioinformatics analysis
CONCLUSION: The enrichment pathways and targets of Lipitor combined with aspirin in PCa are discovered, and DSCC1 silencing can potentiate the effect of Lipitor combined with aspirin in the treatment of PCa.PMID:35926565 | DOI:10.1016/j.taap.2022.116169 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - August 4, 2022 Category: Toxicology Authors: Xiao Wang Yi Wu Junlei Liu Xuetao Xu Zhaojun Sheng Wenfeng Liu Min Chen Yanyan Ma Denggao Zhao Dongli Li Xi Zheng Source Type: research

Identification of target and pathway of aspirin combined with Lipitor treatment in prostate cancer through integrated bioinformatics analysis
CONCLUSION: The enrichment pathways and targets of Lipitor combined with aspirin in PCa are discovered, and DSCC1 silencing can potentiate the effect of Lipitor combined with aspirin in the treatment of PCa.PMID:35926565 | DOI:10.1016/j.taap.2022.116169 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - August 4, 2022 Category: Toxicology Authors: Xiao Wang Yi Wu Junlei Liu Xuetao Xu Zhaojun Sheng Wenfeng Liu Min Chen Yanyan Ma Denggao Zhao Dongli Li Xi Zheng Source Type: research

Identification of target and pathway of aspirin combined with Lipitor treatment in prostate cancer through integrated bioinformatics analysis
CONCLUSION: The enrichment pathways and targets of Lipitor combined with aspirin in PCa are discovered, and DSCC1 silencing can potentiate the effect of Lipitor combined with aspirin in the treatment of PCa.PMID:35926565 | DOI:10.1016/j.taap.2022.116169 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - August 4, 2022 Category: Toxicology Authors: Xiao Wang Yi Wu Junlei Liu Xuetao Xu Zhaojun Sheng Wenfeng Liu Min Chen Yanyan Ma Denggao Zhao Dongli Li Xi Zheng Source Type: research

Identification of target and pathway of aspirin combined with Lipitor treatment in prostate cancer through integrated bioinformatics analysis
CONCLUSION: The enrichment pathways and targets of Lipitor combined with aspirin in PCa are discovered, and DSCC1 silencing can potentiate the effect of Lipitor combined with aspirin in the treatment of PCa.PMID:35926565 | DOI:10.1016/j.taap.2022.116169 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - August 4, 2022 Category: Toxicology Authors: Xiao Wang Yi Wu Junlei Liu Xuetao Xu Zhaojun Sheng Wenfeng Liu Min Chen Yanyan Ma Denggao Zhao Dongli Li Xi Zheng Source Type: research

High-intensity statin treatment is associated with reduced plaque structural stress and remodelling of artery geometry and plaque architecture
CONCLUSION: Our observational study shows that PSSpeak changes over time were associated with baseline disease severity and treatment. The PSSpeak increase seen in advanced lesions with standard treatment was associated with remodelling artery geometry and plaque architecture, but this was not seen after HIS treatment. Smoothing plaques by reducing plaque/lumen roughness, irregularity, and curvature represents a novel mechanism whereby HIS may reduce PSS and, thus may protect against plaque rupture and MACE.PMID:35919883 | PMC:PMC9242039 | DOI:10.1093/ehjopen/oeab039 (Source: Atherosclerosis)
Source: Atherosclerosis - August 3, 2022 Category: Cardiology Authors: Sophie Z Gu Charis Costopoulos Yuan Huang Christos Bourantas Adam Woolf Chang Sun Zhongzhao Teng Sylvain Losdat Lorenz R äber Habib Samady Martin R Bennett Source Type: research

High-intensity statin treatment is associated with reduced plaque structural stress and remodelling of artery geometry and plaque architecture
CONCLUSION: Our observational study shows that PSSpeak changes over time were associated with baseline disease severity and treatment. The PSSpeak increase seen in advanced lesions with standard treatment was associated with remodelling artery geometry and plaque architecture, but this was not seen after HIS treatment. Smoothing plaques by reducing plaque/lumen roughness, irregularity, and curvature represents a novel mechanism whereby HIS may reduce PSS and, thus may protect against plaque rupture and MACE.PMID:35919883 | PMC:PMC9242039 | DOI:10.1093/ehjopen/oeab039 (Source: Atherosclerosis)
Source: Atherosclerosis - August 3, 2022 Category: Cardiology Authors: Sophie Z Gu Charis Costopoulos Yuan Huang Christos Bourantas Adam Woolf Chang Sun Zhongzhao Teng Sylvain Losdat Lorenz R äber Habib Samady Martin R Bennett Source Type: research

Pleiotropic effects of pitavastatin: a pilot study using the saphenous vein endothelial cell model of endothelial injury and prevention of atherosclerosis
CONCLUSIONS: Pleiotropic effects of pitavastatin against cardiovascular diseases appeared to be better; however, additional studies are required to compare statins and to identify new drugs that maintain broader protection from the risks of cardiovascular diseases.PMID:35916819 | DOI:10.26355/eurrev_202207_29310 (Source: Atherosclerosis)
Source: Atherosclerosis - August 2, 2022 Category: Cardiology Authors: B Onal M Alaylioglu G Yenmis A S Dogan E Dursun D Gezen-Ak M Ugurlucan Source Type: research