Statin Use Reduces Radiation-Induced Stroke Risk in Advanced Nasopharyngeal Carcinoma Patients

CONCLUSIONS: Our study provides evidence supporting the beneficial effects of statin use during the CCRT period in reducing radiation-induced stroke risk among patients with advanced NPC undergoing definitive CCRT. Notably, pravastatin and atorvastatin demonstrated significant reductions in stroke occurrence. Furthermore, the findings suggest a dose-response relationship, where higher cumulative doses and greater daily dose intensity of statin use were associated with a lower risk of stroke.PMID:38142934 | DOI:10.1016/j.radonc.2023.110067

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 24, 2023 Category: Radiology Authors: Chuan-Yi Lin Chia-Lun Chang Kuan-Chou Lin Wan-Ming Chen Ben-Chang Shia Po-Hsiu Kuo Szu-Yuan Wu Source Type: research