United States' regulatory approved pharmacotherapies for nuclear reactor explosions and anthrax-associated bioterrorism
Expert Opin Drug Saf. 2023 Aug 18:1-6. doi: 10.1080/14740338.2023.2245748. Online ahead of print.ABSTRACTINTRODUCTION: Nuclear reactor incidents and bioterrorism outbreaks are concerning public health disasters. Little is known about US Food and Drug Administration (FDA)-approved agents that can mitigate consequences of these events. We review FDA data supporting regulatory approvals of these agents.AREAS COVERED: We reviewed pharmaceutical products approved to treat Hematopoietic Acute Radiation Syndrome (H-ARS) and to treat or prevent pulmonary infections following Bacillus anthracis (anthrax) exposure. Four drugs were a...
Source: Expert Opinion on Drug Safety - August 18, 2023 Category: Drugs & Pharmacology Authors: Charles L Bennett Peter Georgantopoulos Robert Peter Gale Kevin Knopf William J Hrushesky Chadi Nabhan James O Armitage Source Type: research
Long-running ProMED email service for alerting world to disease outbreaks is in trouble
The first news about the COVID-19 pandemic came not from a government or a scientific publication, but in an email from a disease-alert system called
ProMED
. This fateful missive in December 2019 about a few cases of a mysterious pneumonia in Wuhan, China, is just one example of how physicians and public health experts around the world have used the 30-year-old, free service to share real-time information about local disease outbreaks with tens of thousands of subscribers.
But ProMED is now on life support. Much of its work came to a screeching halt yesterday when 21 of its 38 paid editors and moderators w...
Source: Science of Aging Knowledge Environment - August 4, 2023 Category: Geriatrics Source Type: research
Whole genome sequencing of Bacillus anthracis isolated from animal in the 1960s, Brazil, belonging to the South America subclade
Comp Immunol Microbiol Infect Dis. 2023 Jul 25;100:102027. doi: 10.1016/j.cimid.2023.102027. Online ahead of print.ABSTRACTBacillus anthracis causes anthrax disease and can affect humans and other animals. This zoonotic disease has an impact on the economic and health aspects. B. anthracis population is divided into three major clades: A (with worldwide distribution), B, and C (restricted to specific regions). Anthrax is most common in agricultural regions of central and southwestern Asia, sub-Saharan Africa, Southern and Eastern Europe, the Caribbean, and Central and South America. Here, we sequenced by short and long rea...
Source: Comparative immunology, microbiology and infectious diseases. - July 30, 2023 Category: Allergy & Immunology Authors: T ânia Sueli de Andrade Carlos Henrique Camargo Karoline Rodrigues Campos Alex Domingos Reis Marlon Benedito do Nascimento Santos Vanessa Nieri Zanelatto Elizabeth Harummyy Takagi Claudio Tavares Sacchi Source Type: research
Self-calibrated HAp:Tb-EDTA paper-based probe with dual emission ratio fluorescence for binary visual and fluorescent detection of anthrax biomarker
Talanta. 2023 Jul 23;266(Pt 1):124979. doi: 10.1016/j.talanta.2023.124979. Online ahead of print.ABSTRACTDevelopment of the portable device is significant for sensitive and rapid detection of an anthrax biomarker dipicolinic acid (DPA), existing in the B. anthracis. In this work, a novel HAp:Tb-EDTA paper-based ratiometric fluorescent sensor was obtained by a simple one-pot method for rapid and sensitive DPA detection. With the increased DPA concentration, the luminescence intensity of HAp (hydroxyapatite) remained constant, and thus applied as the stable reference signal, while the luminescence signal of Tb3+-EDTA was sig...
Source: Talanta - July 28, 2023 Category: Chemistry Authors: Caizhi Lv Shan Pu Lan Wu Xiandeng Hou Source Type: research
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious Disease
Mini Rev Med Chem. 2023 Jul 25. doi: 10.2174/1389557523666230725115324. Online ahead of print.ABSTRACTAlongside the prescription of commonly used antivirals, such as acyclovir, remdesivir, oseltamivir, and ciprofloxacin, the most efficient way to prevent or treat communicable diseases is by vaccination. Vaccines have been the most efficient way to prevent or treat highly transmissible infectious agents, such as Ebola, Anthrax, and Dengue Fever. Most epidemics of these highly transmissible infectious agents occur in places, such as South America, Central America, Tropical Asia, and Africa, where the availability of resource...
Source: Mini Reviews in Medicinal Chemistry - July 25, 2023 Category: Chemistry Authors: Anthony Garcia Oliver Grundmann Source Type: research
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious Disease
Mini Rev Med Chem. 2023 Jul 25. doi: 10.2174/1389557523666230725115324. Online ahead of print.ABSTRACTAlongside the prescription of commonly used antivirals, such as acyclovir, remdesivir, oseltamivir, and ciprofloxacin, the most efficient way to prevent or treat communicable diseases is by vaccination. Vaccines have been the most efficient way to prevent or treat highly transmissible infectious agents, such as Ebola, Anthrax, and Dengue Fever. Most epidemics of these highly transmissible infectious agents occur in places, such as South America, Central America, Tropical Asia, and Africa, where the availability of resource...
Source: Mini Reviews in Medicinal Chemistry - July 25, 2023 Category: Chemistry Authors: Anthony Garcia Oliver Grundmann Source Type: research
A highly stable chain-based EuIII metal-organic framework as the turn-on and blue-shift luminescent sensor for dipicolinic acid
Dalton Trans., 2023, Accepted Manuscript DOI: 10.1039/D3DT01057K, PaperLi Wang, Yulian Zhu, Teng-Fei Zheng, Zi-Hao Zhu, Yan Peng, Yongquan Wu, Jing-Lin Chen, Sui-Jun Liu, He-Rui Wen The development of a rapid and selective method for the identification of dipicolinic acid (DPA), a specific biomarker in bacillus anthracis spores, is of great importance for the avoidance of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - July 6, 2023 Category: Chemistry Authors: Li Wang Source Type: research
Red-emissive carbon nanostructure-anchored molecularly imprinted Er-BTC MOF: a biosensor for visual anthrax monitoring
Analyst, 2023, Advance Article DOI: 10.1039/D3AN00865G, PaperSolmaz Norouzi, Kheibar Dashtian, Fereshteh Amourizi, Rouholah Zare-Dorabei Investigating effective fluorescence strategies for real-time monitoring of dipicolinic acid (DPA) is of paramount importance in safeguarding human health. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - June 27, 2023 Category: Chemistry Authors: Solmaz Norouzi Source Type: research
Epidemiology of Pathogens Listed as Potential Bioterrorism Agents, the Netherlands, 2009 ‒2019
Emerg Infect Dis. 2023 Jul;29(7):1-9. doi: 10.3201/eid2907.221769.ABSTRACTWe provide incidences (cases/10 million persons) in the Netherlands during 2009-2019 for pathogens listed as potential bioterrorism agents. We included pathogens from the highest categories of the European Medicines Agency or the US Centers for Disease Control and Prevention. Notifiable diseases and recently published data were used to calculate the average annual incidence. Coxiella burnetii had the highest incidence because of a Q fever epidemic during 2007-2010. Incidence then decreased to 10.8 cases/. Pathogens with an incidence >1 were Brucel...
Source: Emerging Infectious Diseases - June 22, 2023 Category: Infectious Diseases Authors: Jorrit Broertjes Eelco Franz Ingrid H M Friesema Hugo-Jan Jansen Frans A G Reubsaet Saskia A Rutjes Cornelis Stijnis Bettie C G Voordouw Maaike C de Vries Daan W Notermans Martin P Grobusch Source Type: research
Epidemiology of Pathogens Listed as Potential Bioterrorism Agents, the Netherlands, 2009 ‒2019
Emerg Infect Dis. 2023 Jul;29(7):1-9. doi: 10.3201/eid2907.221769.ABSTRACTWe provide incidences (cases/10 million persons) in the Netherlands during 2009-2019 for pathogens listed as potential bioterrorism agents. We included pathogens from the highest categories of the European Medicines Agency or the US Centers for Disease Control and Prevention. Notifiable diseases and recently published data were used to calculate the average annual incidence. Coxiella burnetii had the highest incidence because of a Q fever epidemic during 2007-2010. Incidence then decreased to 10.8 cases/. Pathogens with an incidence >1 were Brucel...
Source: Emerging Infectious Diseases - June 22, 2023 Category: Infectious Diseases Authors: Jorrit Broertjes Eelco Franz Ingrid H M Friesema Hugo-Jan Jansen Frans A G Reubsaet Saskia A Rutjes Cornelis Stijnis Bettie C G Voordouw Maaike C de Vries Daan W Notermans Martin P Grobusch Source Type: research
Sensors, Vol. 23, Pages 5820: Research on Detection of Ultra-Low Concentration Anthrax Protective Antigen Using Graphene Field-Effect Transistor Biosensor
Conclusions: By constructing a Gr−FET device based on CVD-grown graphene and selecting a PA monoclonal antibody as the bio-recognition element, a highly sensitive, specific, and repeatable Gr−FET biosensor was successfully prepared for detecting extremely low concentrations of anthrax protective antigen (PA). This biosensor is expected to have a wide range of applications in clinical medicine and biological safety monitoring. (Source: Sensors)
Source: Sensors - June 22, 2023 Category: Biotechnology Authors: Ting Liang Jingfei Chen Rui Yan Huaning Jiang Hexi Li Tags: Article Source Type: research
Electrochemical, optical and mass-based immunosensors: A comprehensive review of Bacillus anthracis detection methods
Anal Biochem. 2023 Jun 19;675:115215. doi: 10.1016/j.ab.2023.115215. Online ahead of print.ABSTRACTA biosensor is an analytical device whose main components include transducer and bioreceptor segments. The combination of biological recognition with the ligand is followed by transformation into physical or chemical signals. Many publications describe biological sensors as user-friendly, easy, portable, and less time-consuming than conventional methods. Among major categories of methods for the detection of Bacillus anthracis, such as culture-based microbiological method, polymerase chain reaction (PCR) and enzyme-linked imm...
Source: Analytical Biochemistry - June 21, 2023 Category: Biochemistry Authors: Renata Ty śkiewicz Magdalena Fedorowicz Aleksandra Nakonieczna Paulina Zieli ńska Magdalena Kwiatek Lidia Mizak Source Type: research
