CDC Guidelines for the Prevention and Treatment of Anthrax, 2023
MMWR Recomm Rep. 2023 Nov 17;72(6):1-47. doi: 10.15585/mmwr.rr7206a1.ABSTRACTTHIS REPORT UPDATES PREVIOUS CDC GUIDELINES AND RECOMMENDATIONS ON PREFERRED PREVENTION AND TREATMENT REGIMENS REGARDING NATURALLY OCCURRING ANTHRAX. ALSO PROVIDED ARE A WIDE RANGE OF ALTERNATIVE REGIMENS TO FIRST-LINE ANTIMICROBIAL DRUGS FOR USE IF PATIENTS HAVE CONTRAINDICATIONS OR INTOLERANCES OR AFTER A WIDE-AREA AEROSOL RELEASE OF: Bacillus anthracis spores if resources become limited or a multidrug-resistant B. anthracis strain is used (Hendricks KA, Wright ME, Shadomy SV, et al.; Workgroup on Anthrax Clinical Guidelines. Centers for Disease...
Source: Emerging Infectious Diseases - November 14, 2023 Category: Infectious Diseases Authors: William A Bower Yon Yu Marissa K Person Corinne M Parker Jordan L Kennedy David Sue Elisabeth M Hesse Rachel Cook John Bradley J ürgen B Bulitta Adolf W Karchmer Robert M Ward Shana Godfred Cato Kevin Chatham Stephens Katherine A Hendricks Source Type: research
Genetic evidence for the interaction between Bacillus anthracis-encoded phage receptors and their cognate phage-encoded receptor binding proteins
Bacteriophages such as γ and AP50c have been shown to infect strains of Bacillus anthracis with high specificity, and this feature has been exploited in the development of bacterial detection assays. To better understand the emergence of phage resistance, and thus the potential failure of such assays, it is important to identify the host and phage receptors necessary for attachment and entry. Using genetic approaches, the bacterial receptors of AP50c and γ have been identified as sap and GamR, respectively. A second AP50c-like phage, Wip1, also appears to use sap as a receptor. In parallel with this work, the cognate pha...
Source: Frontiers in Microbiology - October 31, 2023 Category: Microbiology Source Type: research
Utilizing targeted integration CHO pools to potentially accelerate the GMP manufacturing of monoclonal and bispecific antibodies
AbstractMonoclonal antibodies (mAbs) are effective therapeutic agents against many acute infectious diseases including COVID-19, Ebola, RSV,Clostridium difficile, and Anthrax. mAbs can therefore help combat a future pandemic. Unfortunately, mAb development typically takes years, limiting its potential to save lives during a pandemic. Therefore “pandemic mAb” timelines need to be shortened. One acceleration tool is “deferred cloning” and leverages new Chinese hamster ovary (CHO) technology based on targeted gene integration (TI). CHO pools, instead of CHO clones, can be used for Phase I/II clinical material producti...
Source: Biotechnology Progress - October 25, 2023 Category: Biotechnology Authors: Gavin C. Barnard,
Michelle Zhou,
Amy Shen,
Inn H. Yuk,
Michael W. Laird Tags: RESEARCH ARTICLE Source Type: research
Spatial Analysis of Human and Livestock Anthrax in Lai Chau Province, Vietnam (2004-2021)
This study informs vaccination strategy and targeted surveillance and control measures in newly identified high-risk areas and seasons of anthrax.PMID:37866728 | DOI:10.1016/j.actatropica.2023.107044 (Source: Acta Tropica)
Source: Acta Tropica - October 22, 2023 Category: Infectious Diseases Authors: Tan Luong Do Kien Tran Anh Hung Pham Thi Thu-Ha Hoang Van Khang Pham Quang Thai Pham Thi Mai Hung Tran Minh Hoa Luong Thanh Long Pham Jason K Blackburn Source Type: research
Spatial Analysis of Human and Livestock Anthrax in Lai Chau Province, Vietnam (2004-2021)
This study informs vaccination strategy and targeted surveillance and control measures in newly identified high-risk areas and seasons of anthrax.PMID:37866728 | DOI:10.1016/j.actatropica.2023.107044 (Source: Acta Tropica)
Source: Acta Tropica - October 22, 2023 Category: Infectious Diseases Authors: Tan Luong Do Kien Tran Anh Hung Pham Thi Thu-Ha Hoang Van Khang Pham Quang Thai Pham Thi Mai Hung Tran Minh Hoa Luong Thanh Long Pham Jason K Blackburn Source Type: research
Spatial Analysis of Human and Livestock Anthrax in Lai Chau Province, Vietnam (2004-2021)
This study informs vaccination strategy and targeted surveillance and control measures in newly identified high-risk areas and seasons of anthrax.PMID:37866728 | DOI:10.1016/j.actatropica.2023.107044 (Source: Acta Tropica)
Source: Acta Tropica - October 22, 2023 Category: Infectious Diseases Authors: Tan Luong Do Kien Tran Anh Hung Pham Thi Thu-Ha Hoang Van Khang Pham Quang Thai Pham Thi Mai Hung Tran Minh Hoa Luong Thanh Long Pham Jason K Blackburn Source Type: research
Anthrax in one health in Southern and Southeastern Europe - the effect of climate change?
AbstractAnthrax is a serious infection caused byBacillus anthracis. The anthracis spores are highly resistant and can persist in the environment for several decades. Therefore, anthrax is considered a global health threat affecting wildlife, livestock, and the general public. The resistance mechanism is influenced not only by the environment or the ecological niche but also by virulence factors. In the last 10 years the Southern and Southeastern Europe have been confronted with this threat. Recently, there have been 8 human anthrax cases reported in Croatia (2022), and 4 cases in Romania (2023). Moreover, this incident and...
Source: Veterinary Research Communications - October 21, 2023 Category: Veterinary Research Source Type: research
Anthrax lethal toxin and tumor necrosis factor- α synergize on intestinal epithelia to induce mouse death
Protein Cell. 2023 Oct 19:pwad050. doi: 10.1093/procel/pwad050. Online ahead of print.ABSTRACTBacillus anthracis (B. anthracis) lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system. The interplay between LT and the host responses is important in the pathogenesis, but our knowledge on this interplay remains limited. Tumor necrosis factor-α (TNF) is a pleiotropic pro-inflammatory cytokine induced by bacterial infections. Since LT accumulates and cytokines, predominantly TNF, ama...
Source: Protein and Cell - October 19, 2023 Category: Cytology Authors: Xinhe Gao Teng Teng Yifei Liu Tingting Ai Rui Zhao Yilong Fu Peipei Zhang Jiahuai Han Yingying Zhang Source Type: research
