Outbreak of anthrax in livestock with human occupational exposures – Minnesota, 2023
. (Source: Journal of Agromedicine)
Source: Journal of Agromedicine - January 24, 2024 Category: Environmental Health Authors: Kelly Elizabeth SchenkK. CornilleJ. CaterA. R. VieiraS. HolzbauerM. ByeJ. Scheftela Council for State and Territorial Epidemiologists Applied Epidemiology Fellowship, Minnesota Department of Health, St. Paul, MN, USAb Minnesota Department of Health, Zoono Source Type: research
A promising snakebite treatment seemed ready for prime time. Then, it backfired
A single bite from the terciopelo (
Bothrops asper
), a viper that lives in Central America and northern South America, is responsible for hundreds of fatalities each year. Many more are maimed by the venom’s muscle-destroying toxins, as existing treatments are largely ineffective at preventing tissue death. Now, researchers report that a once-promising new drug, an antibody that counteracts a pernicious toxin in the viper’s venom, has failed in animal trials. But the way that it failed—worsening the toxin’s damage in mice and eventually killing the animals instead of protecting them—may
reveal new...
Source: Science of Aging Knowledge Environment - January 16, 2024 Category: Geriatrics Source Type: research
Molecular characterization of an outbreak-involved Bacillus anthracis strain confirms the spillover of anthrax from West Africa
ConclusionsWe successfully identified a large-scale anthrax outbreak in Sierra Leone. The causative isolate ofB. anthracis, BaSL2022, phylogenetically bridged other lineages in A.Br.153 clade and neighboring genetic groups, A.Br.144 and A.Br.148, eventually confirming the spillover of anthrax from West Africa. Given the wide dissemination ofB. anthracis spores, it is highly advisable to effectively monitor the potential reoccurrence of anthrax outbreaks and to launch campaigns to improve public awareness regarding anthrax in Sierra Leone.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - January 15, 2024 Category: Infectious Diseases Source Type: research
New bacteriophage-derived lysins, LysJ and LysF, with the potential to control Bacillus anthracis
AbstractBacillus anthracis is an etiological agent of anthrax, a severe zoonotic disease that can be transmitted to people and cause high mortalities. Bacteriophages and their lytic enzymes, endolysins, have potential therapeutic value in treating infections caused by this bacterium as alternatives or complements to antibiotic therapy. They can also be used to identify and detectB. anthracis. Endolysins of twoB. anthracis Wbetavirus phages, J5a and F16Ba which were described by us recently, differ significantly from the best-knownB. anthracis phage endolysin PlyG fromWbetavirus genus bacteriophage Gamma and a few otherWbet...
Source: European Journal of Applied Physiology - January 11, 2024 Category: Physiology Source Type: research
New bacteriophage-derived lysins, LysJ and LysF, with the potential to control Bacillus anthracis
Appl Microbiol Biotechnol. 2024 Dec;108(1):1-14. doi: 10.1007/s00253-023-12839-z. Epub 2024 Jan 9.ABSTRACTBacillus anthracis is an etiological agent of anthrax, a severe zoonotic disease that can be transmitted to people and cause high mortalities. Bacteriophages and their lytic enzymes, endolysins, have potential therapeutic value in treating infections caused by this bacterium as alternatives or complements to antibiotic therapy. They can also be used to identify and detect B. anthracis. Endolysins of two B. anthracis Wbetavirus phages, J5a and F16Ba which were described by us recently, differ significantly from the best...
Source: Applied Microbiology and Biotechnology - January 9, 2024 Category: Microbiology Authors: Aleksandra Nakonieczna Agnieszka Topolska-Wo ś Ma łgorzata Łobocka Source Type: research
Impact of traditional cutaneous scarification on anthrax lesions - a series of cases from Cubal, Angola.
Anthrax is a worldwide zoonosis caused by Bacillus anthracis, a Gram-positive spore-forming bacterium. Many animals are susceptible, although grazing herbivores are the most commonly affected and the usual source of infection for humans. Herbivores often become infected by B. anthracis spores from the soil while grazing, and then return the spores to the soil when they die. The spores can last in the soil for decades and depending mainly on climatic conditions and soil composition. [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - January 7, 2024 Category: Infectious Diseases Authors: Joan Mart ínez-Campreciós, Milagros Moreno, Fernando Salvador, Ester Del Barrio-Tofiño, Arlete Nindia, Maria Luisa Aznar, Israel Molina Source Type: research
Impact of traditional cutaneous scarification on anthrax lesions: A series of cases from Cubal, Angola
Anthrax is a worldwide zoonosis caused by Bacillus anthracis, a Gram-positive spore-forming bacterium. Many animals are susceptible, although grazing herbivores are the most commonly affected and the usual source of infection for humans. Herbivores often become infected by B. anthracis spores from the soil when grazing and then return the spores to the soil when they die. The spores can last in the soil for decades, depending mainly on climatic conditions and soil composition [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - January 7, 2024 Category: Infectious Diseases Authors: Joan Mart ínez-Campreciós, Milagros Moreno, Fernando Salvador, Ester Del Barrio-Tofiño, Arlete Nindia, Maria Luisa Aznar, Israel Molina Source Type: research
A terbium-functionalized ZIF-8 nanosensor for rapid and sensitive detection of an anthrax spore biomarker
New J. Chem., 2024, Advance Article DOI: 10.1039/D3NJ04760A, PaperXurong Zuo, Pengfei Liu, Qinhao Sun, Jiahui Huang, Yuwei Zhang, Xuecheng Zhu, Runqi Chen, Xiangyu Meng Because anthrax spores are highly lethal to humans and animals as well as potential biological warfare agents, there is a great need for rapid, sensitive, and selective quantification of dipicolinic acid (DPA) as a biomarker for anthrax spores. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - January 3, 2024 Category: Chemistry Authors: Xurong Zuo Source Type: research
Advances in machine learning-based bacteria analysis for forensic identification: identity, ethnicity, and site of occurrence
When faced with an unidentified body, identifying the victim can be challenging, particularly if physical characteristics are obscured or masked. In recent years, microbiological analysis in forensic science has emerged as a cutting-edge technology. It not only exhibits individual specificity, distinguishing different human biotraces from various sites of occurrence (e.g., gastrointestinal, oral, skin, respiratory, and genitourinary tracts), each hosting distinct bacterial species, but also offers insights into the accident’s location and the surrounding environment. The integration of machine learning with microbiomics ...
Source: Frontiers in Microbiology - December 21, 2023 Category: Microbiology Source Type: research
Efficacy of different AV7909 dose regimens in a nonclinical model of pulmonary anthrax
Volume 19, Issue 3, December 2023 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - December 20, 2023 Category: Allergy & Immunology Authors: Lisa HenningMichael AndersonCheryl TriplettTammy SmithKevin BoyceLindsay HendeyAlex RidenourJason EngDavid SchaeufeleEhran WilsonCarol L. SabourinLily E. AdamsTahar BabasLindsay ParishDaniel Wolfea Battelle Biomedical Research Center, Columbus, OH, USAb T Source Type: research
Terbium functionalized ZIF-8 nanosensor for rapid and sensitive detection of anthrax spore biomarker
New J. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3NJ04760A, Paperxurong zuo, pengfei liu, Qinhao Sun, Jiahui Huang, Yuwei Zhang, Xuecheng Zhu, Runqi Chen, xiangyu Meng Because anthrax spores are highly lethal to humans and animals as well as potential biological warfare agents, there is a great need for rapid, sensitive, and selective quantification of dipicolinic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - December 18, 2023 Category: Chemistry Authors: xurong zuo Source Type: research
Animal-to-Human Dose Translation of ANTHRASIL for Treatment of Inhalational Anthrax in Healthy Adults, Obese Adults, and Pediatric Subjects
Clin Pharmacol Ther. 2023 Dec 11. doi: 10.1002/cpt.3097. Online ahead of print.ABSTRACTAnthrax Immune Globulin Intravenous (AIGIV [ANTHRASIL]), was developed for the treatment of toxemia associated with inhalational anthrax. It is a plasma product collected from individuals vaccinated with anthrax vaccine and contains antitoxin IgG antibodies against Bacillus anthracis protective antigen. A pharmacokinetic (PK) and exposure-response model was constructed to assess the PKs of AIGIV in anthrax-free and anthrax-exposed rabbits, non-human primates and anthrax-free humans, as well as the relationship between AIGIV exposure and ...
Source: Clinical Pharmacology and Therapeutics - December 12, 2023 Category: Drugs & Pharmacology Authors: Martin Beliveau Igor Rubets Drobic Bojan Christine Hall Derek Toth Shantha Kodihalli Srinivas Kammanadiminti Source Type: research
Assessing and Prioritizing Zoonotic Diseases in Punjab, India: A One Health Approach
AbstractZoonotic diseases have a significant impact on both human and animal health globally. The present study was planned to prioritize the zoonoses in Punjab state of India. To develop a zoonotic disease prioritization scoring system, a comprehensive approach has been taken, including literature review, key person interviews with animal health experts (n = 12) and medical professionals (n = 7), and nine focus group discussions (FGDs) with veterinary academicians, medical professionals, and field veterinary doctors. The scoring system comprises of seven major criteria, each assigned a weightage score (ws): preval...
Source: EcoHealth - November 21, 2023 Category: Environmental Health Source Type: research
