Study on the detection of anthrax by ICP-MS based on gold nanoparticle labeling
CONCLUSION: The proposed method has numerous advantages, including simplicity of operation, high sensitivity, and specificity, which provides a new idea for the detection of anthrax. Importantly, this methodology has good potential for the detection of other biological substances such as bacteria and viruses by changing the modification sequence on the nanoparticle probe.PMID:37066929 | DOI:10.3233/THC-236024 (Source: Technology and Health Care)
Source: Technology and Health Care - April 17, 2023 Category: Medical Devices Authors: Zeyong Xu Tengbo Ma Xiao Han Guohong Liu Teng Luo Mengbin Yu Lili Han Kaichuang Chen Gaoyun Chen Source Type: research
Study on the detection of anthrax by ICP-MS based on gold nanoparticle labeling
CONCLUSION: The proposed method has numerous advantages, including simplicity of operation, high sensitivity, and specificity, which provides a new idea for the detection of anthrax. Importantly, this methodology has good potential for the detection of other biological substances such as bacteria and viruses by changing the modification sequence on the nanoparticle probe.PMID:37066929 | DOI:10.3233/THC-236024 (Source: Technology and Health Care)
Source: Technology and Health Care - April 17, 2023 Category: Medical Devices Authors: Zeyong Xu Tengbo Ma Xiao Han Guohong Liu Teng Luo Mengbin Yu Lili Han Kaichuang Chen Gaoyun Chen Source Type: research
Study on the detection of anthrax by ICP-MS based on gold nanoparticle labeling
CONCLUSION: The proposed method has numerous advantages, including simplicity of operation, high sensitivity, and specificity, which provides a new idea for the detection of anthrax. Importantly, this methodology has good potential for the detection of other biological substances such as bacteria and viruses by changing the modification sequence on the nanoparticle probe.PMID:37066929 | DOI:10.3233/THC-236024 (Source: Technology and Health Care)
Source: Technology and Health Care - April 17, 2023 Category: Medical Devices Authors: Zeyong Xu Tengbo Ma Xiao Han Guohong Liu Teng Luo Mengbin Yu Lili Han Kaichuang Chen Gaoyun Chen Source Type: research
Study on the detection of anthrax by ICP-MS based on gold nanoparticle labeling
CONCLUSION: The proposed method has numerous advantages, including simplicity of operation, high sensitivity, and specificity, which provides a new idea for the detection of anthrax. Importantly, this methodology has good potential for the detection of other biological substances such as bacteria and viruses by changing the modification sequence on the nanoparticle probe.PMID:37066929 | DOI:10.3233/THC-236024 (Source: Technology and Health Care)
Source: Technology and Health Care - April 17, 2023 Category: Medical Devices Authors: Zeyong Xu Tengbo Ma Xiao Han Guohong Liu Teng Luo Mengbin Yu Lili Han Kaichuang Chen Gaoyun Chen Source Type: research
Study on the detection of anthrax by ICP-MS based on gold nanoparticle labeling
CONCLUSION: The proposed method has numerous advantages, including simplicity of operation, high sensitivity, and specificity, which provides a new idea for the detection of anthrax. Importantly, this methodology has good potential for the detection of other biological substances such as bacteria and viruses by changing the modification sequence on the nanoparticle probe.PMID:37066929 | DOI:10.3233/THC-236024 (Source: Technology and Health Care)
Source: Technology and Health Care - April 17, 2023 Category: Medical Devices Authors: Zeyong Xu Tengbo Ma Xiao Han Guohong Liu Teng Luo Mengbin Yu Lili Han Kaichuang Chen Gaoyun Chen Source Type: research
Study on the detection of anthrax by ICP-MS based on gold nanoparticle labeling
CONCLUSION: The proposed method has numerous advantages, including simplicity of operation, high sensitivity, and specificity, which provides a new idea for the detection of anthrax. Importantly, this methodology has good potential for the detection of other biological substances such as bacteria and viruses by changing the modification sequence on the nanoparticle probe.PMID:37066929 | DOI:10.3233/THC-236024 (Source: Technology and Health Care)
Source: Technology and Health Care - April 17, 2023 Category: Medical Devices Authors: Zeyong Xu Tengbo Ma Xiao Han Guohong Liu Teng Luo Mengbin Yu Lili Han Kaichuang Chen Gaoyun Chen Source Type: research
A turn-on fluorescent Zn(II) metal –organic framework sensor for quantitative anthrax biomarker detection
Dalton Trans., 2023, Advance Article DOI: 10.1039/D3DT00619K, PaperChao Hong, Ling Li, Ji-Yong Zou, Li Zhang, Sheng-Yong You A Zn(II) MOF for turn-on fluorescent sensor matrix of DPA detection is synthesized. DFT calculations show the sensing behavior was induced by the intermolecular PET transition and hydrogen-bonding interaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - April 14, 2023 Category: Chemistry Authors: Chao Hong Source Type: research
Immunogenicity and Protective Efficacy of Recombinant Protective Antigen Anthrax Vaccine (GC1109) in A/J Mice Model
Vaccine. 2023 Apr 11:S0264-410X(23)00386-9. doi: 10.1016/j.vaccine.2023.04.002. Online ahead of print.ABSTRACTA recombinant protective antigen anthrax vaccine (GC1109) is being developed as a new-generation vaccine by the Korea Disease Control and Prevention Agency. In accordance with the ongoing step 2 of phase II clinical trials, the immunogenicity and protective efficacy of the booster dose of GC1109 were evaluated in A/J mice after 3 serial vaccinations at 4-week intervals. The results indicated that the booster dose significantly increased the production of anti-protective antigen (PA) IgG and toxin-neutralizing antib...
Source: Vaccine - April 13, 2023 Category: Allergy & Immunology Authors: Gyu-Lee Kim Seong Wook Pyo Hwajung Yi So-Hyeon Kim Hwachul Shin Min-Ah Yu Yi-Rang Hwang Sang-Yoon Choi Jun Ho Jeon Su Kyoung Jo Gi-Eun Rhie Source Type: research
Immunogenicity and Protective Efficacy of Recombinant Protective Antigen Anthrax Vaccine (GC1109) in A/J Mice Model
Vaccine. 2023 Apr 11:S0264-410X(23)00386-9. doi: 10.1016/j.vaccine.2023.04.002. Online ahead of print.ABSTRACTA recombinant protective antigen anthrax vaccine (GC1109) is being developed as a new-generation vaccine by the Korea Disease Control and Prevention Agency. In accordance with the ongoing step 2 of phase II clinical trials, the immunogenicity and protective efficacy of the booster dose of GC1109 were evaluated in A/J mice after 3 serial vaccinations at 4-week intervals. The results indicated that the booster dose significantly increased the production of anti-protective antigen (PA) IgG and toxin-neutralizing antib...
Source: Vaccine - April 13, 2023 Category: Allergy & Immunology Authors: Gyu-Lee Kim Seong Wook Pyo Hwajung Yi So-Hyeon Kim Hwachul Shin Min-Ah Yu Yi-Rang Hwang Sang-Yoon Choi Jun Ho Jeon Su Kyoung Jo Gi-Eun Rhie Source Type: research
A self-designed device integrated with a Fermat spiral microfluidic chip for ratiometric and automated point-of-care testing of anthrax biomarker in real samples
Biosens Bioelectron. 2023 Mar 31;230:115283. doi: 10.1016/j.bios.2023.115283. Online ahead of print.ABSTRACTA desirable lanthanide-based ratiometric fluorescent probe was designed and integrated into a self-designed Fermat spiral microfluidic chip (FS-MC) for the automated determination of a unique bacterial endospore biomarker, dipicolinic acid (DPA), with high selectivity and sensitivity. Here, a blue emission wavelength at 425 nm was generated in the Fermat spiral structure by mixing the europium (Eu3+) and luminol to form the Eu3+/Luminol sensing probe. DPA in the reservoir can be used to specifically bind to Eu3+ unde...
Source: Biosensors and Bioelectronics - April 5, 2023 Category: Biotechnology Authors: Xiaodong Lin Haotian Wu Shiyu Zeng Tao Peng Pan Zhang Xinhua Wan Yihan Lang Biao Zhang Yanwei Jia Ren Shen Binfeng Yin Source Type: research
GSE220794 Beyond the spore: the exosporium sugar anthrose impacts vegetative Bacillus anthracis gene regulation in cis and trans
Contributor : Michael H NorrisSeries Type : Expression profiling by high throughput sequencingOrganism : Bacillus anthracisIn preliminary experiments, the absence of anthrose in our genetic Sterne knockout was found to decrease pagA expression in BHI broth containing glucose (Fig 5A and B). This contrasted with the large spike in pagA expression when the Sterne antC mutant is grown in protein rich HIB media which does not contain sugars. When exogenous anthrose was added during growth in BHI broth, expression from PpagA increased in both WT (purple line in Fig 5A) and antC Sterne (purple line in Fig 5B). Many bacteri...
Source: GEO: Gene Expression Omnibus - April 4, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Bacillus anthracis Source Type: research
A turn-on fluorescent Zn(II) metal −organic framework sensor for quantitative anthrax biomarker detection
Dalton Trans., 2023, Accepted Manuscript DOI: 10.1039/D3DT00619K, PaperChao Hong, Ling Li, Ji-Yong Zou, Li Zhang, Shengyong You 2, 6-pyridine dicarboxylic acid (DPA) is considered as one of the main anthrax biomarkers, and the detection of DPA is of great significance. This work presented a Zn(II) based metal-organic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - March 31, 2023 Category: Chemistry Authors: Chao Hong Source Type: research
Efficacy of ANTHRASIL (Anthrax Immune Globulin Intravenous (Human)) in rabbit and nonhuman primate models of inhalational anthrax: Data supporting approval under animal rule
by Srinivas Kammanadiminti, Jason Comer, Gabriel Meister, Trevor Carnelley, Derek Toth, Shantha Kodihalli
To meet the requirements of the Animal Rule, the efficacy of monotherapy with ANTHRASIL® (Anthrax Immune Globulin Intravenous (Human)) for inhalational anthrax was evaluated in blinded studies using rabbit and nonhuman primate models. Animals in both studies were randomized to treatment groups exposed to ~ 200 LD50Bacillus anthracis (Ames strain) spores by the aerosol route to induce inhalational anthrax. Rabbits (N = 50/group) were treated with either 15 U/kg ANTHRASIL or a volume-matching dose of IGIV after disease...
Source: PLoS One - March 17, 2023 Category: Biomedical Science Authors: Srinivas Kammanadiminti Source Type: research
