Molecules, Vol. 25, Pages 4360: Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells
Berthon Phila Raharivelomanana Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-q...
Source: Molecules - September 23, 2020 Category: Chemistry Authors: Kristelle Hughes Raimana Ho St éphane Greff Edith Filaire Edwige Ranouille Claire Chazaud Ga ëtan Herbette Jean-Fran çois Butaud Jean-Yves Berthon Phila Raharivelomanana Tags: Article Source Type: research

Skin Toxicity: Clinical Summary of the ONS Guidelines ™ for Cancer Treatment-Related Skin Toxicity.
Skin Toxicity: Clinical Summary of the ONS Guidelines™ for Cancer Treatment-Related Skin Toxicity. Clin J Oncol Nurs. 2020 Oct 01;24(5):561-565 Authors: Wiley K, Ebanks GL, Shelton G, Strelo J, Ciccolini K Abstract Cancer treatment-related skin toxicities are a frequent and distressing side effect of antineoplastic therapies, especially chemotherapy and targeted therapies. Skin toxicities associated with these therapies can include rashes, hand-foot skin reaction, hand-foot syndrome, and hair loss. These symptoms cause not only physical pain and discomfort but also psychological distress, and th...
Source: Clinical Journal of Oncology Nursing - September 21, 2020 Category: Nursing Authors: Wiley K, Ebanks GL, Shelton G, Strelo J, Ciccolini K Tags: Clin J Oncol Nurs Source Type: research

Expression of survivin and p53 genes in patients with alopecia areata: A case-control study.
Abstract BACKGROUND: Alopecia areata is a common non-scarring hair loss disorder. It has been generally recognised as a loss of immune privilege leading to an autoimmune attack upon anagen hair follicles. Survivin is one of the apoptosis inhibitor proteins, responsible for apoptosis suppression and cell cycle regulation. Survivin expression has been demonstrated in the matrix and outer root sheath keratinocytes of anagen hair follicles. Survivin overexpression was shown in several autoimmune diseases, and it was postulated that it contributes to the survival of self-reactive T and B cells. P53 is a tumour suppress...
Source: The Australasian Journal of Dermatology - September 20, 2020 Category: Dermatology Authors: Marie REM, Abd El-Fadeal NM, Atef LM Tags: Australas J Dermatol Source Type: research

Spironolactone in Dermatology: Uses in Acne, Hidradenitis Suppurativa, Female Pattern Baldness, and Hirsutism
Publication date: Available online 18 September 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): P. Vargas-Mora, D. Morgado-Carrasco (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - September 19, 2020 Category: Dermatology Source Type: research

Effect of oral minoxidil for alopecia: Systematic review
Israel Junior Borges do Nascimento, Matthew Harries, Vanessa Barreto Rocha, Jacqueline Y Thompson, Chun Hoong Wong, Hamed Kord Varkaneh, Nathália Sernizon Guimarães, Alair Junior Rocha Arantes, Milena Soriano MarcolinoInternational Journal of Trichology 2020 12(4):147-155 Patients with major presentations of alopecia experience physically harmful effects and psychological comorbidities, such as depression and anxiety. Oral minoxidil (OM) has been suggested by dermatologists as a potential remedy; however, its effectiveness remains unclear. This systematic review aims to collate published studies and to analyze t...
Source: International Journal of Trichology - September 19, 2020 Category: Dermatology Authors: Israel Junior Borges do Nascimento Matthew Harries Vanessa Barreto Rocha Jacqueline Y Thompson Chun Hoong Wong Hamed Kord Varkaneh Nath & #225;lia Sernizon Guimar & #227;es Alair Junior Rocha Arantes Milena Soriano Marcolino Source Type: research

Dermoscopic assessment of microneedling alone versus microneedling with platelet-rich plasma in cases of male pattern alopecia: A split-head comparative study
Conclusion: To the best of our knowledge, this is the first split scalp study for MPA. We conclude that MN and PRP are both effective in treatment of androgenetic alopecia and improve the hair parameters and patient satisfaction. However, no additional effect of PRP over MN was observed. Both these therapies are safe and well tolerated without any major side effects. Limitations of our study were small sample size and lack of long-term follow-up. (Source: International Journal of Trichology)
Source: International Journal of Trichology - September 19, 2020 Category: Dermatology Authors: Kartikay Aggarwal Sanjeev Gupta Ravi Shankar Jangra Aneet Mahendra Anuradha Yadav Aastha Sharma Source Type: research

The assessment of hair transplantation outcomes in cicatricial alopecia
Conclusion: Scarring in CA has a significant effect on quality of life of affected patients. HT when done taking into consideration the stability of disease has good-to-excellent outcomes thus leading to a positive impact on the patient's life. (Source: International Journal of Trichology)
Source: International Journal of Trichology - September 19, 2020 Category: Dermatology Authors: C Madura N Vinay MR Kusuma S Harsha BS Chandrashekar Source Type: research

Improvement of cell proliferation and antioxidant activity of silymarin in hair follicles dermal papillae isolated from the human scalp: Comparison with vitamin C effects
Conclusion: The overall result shows that cell proliferation and TAC significantly increased. However, iNOS, ROS, and COX2 levels were decreased. (Source: International Journal of Trichology)
Source: International Journal of Trichology - September 19, 2020 Category: Dermatology Authors: Hamid Reza Ahmadi Ashtiani Asma Dadgar Melika Akaberi Source Type: research

Increased association between previous pregnancies and use of chemical relaxers in 74 women with central centrifugal cicatricial alopecia
Conclusion: We identified an association between previous pregnancies and use of chemical relaxers in patients diagnosed with CCCA when compared to controls. These findings may help to plan prospective studies aiming at establishing a more concrete link between hormones and CCCA. (Source: International Journal of Trichology)
Source: International Journal of Trichology - September 19, 2020 Category: Dermatology Authors: Manasa Narasimman Valeria De Bedout David E Castillo Mariya I Miteva Source Type: research

More is not always better in hair growth factors. epidermal growth factor: hair growth factor involved in alopecia areata pathogenesis
Conclusions: Elevated hair-specific growth factor as EGF is not always a good sign for hair growth and functioning promotor inducing hair recovery, but it may be linked to the pathogenesis of hair disorders as AA. (Source: International Journal of Trichology)
Source: International Journal of Trichology - September 19, 2020 Category: Dermatology Authors: Asmaa M El-Refai Doaa Mohamed Elhabak Rana Atef Khashaba Source Type: research

Clinical experience with oral tofacitinib in a patient with alopecia areata universalis and rheumatoid arthritis
Daniele Tiemi Abe, Letícia Mari Tashima, Flavia Machado Alves Basilio, Fabiane Mulinari-BrennerInternational Journal of Trichology 2020 12(4):188-190 Alopecia areata (AA) is a chronic and autoimmune disease frequently characterized by a challenge management between dermatologists. At present, JAK-inhibitors have demonstrated encouraging results in AA treatment. Therefore, this study reports a case of alopecia universalis in a patient with rheumatoid arthritis (RA), whose methotrexate therapy shown unsatisfactory response in RA control. After the introduction of 10 mg (oral route) per day of tofacitinib, a JAK-inhib...
Source: International Journal of Trichology - September 19, 2020 Category: Dermatology Authors: Daniele Tiemi Abe Let í cia Mari Tashima Flavia Machado Alves Basilio Fabiane Mulinari-Brenner Source Type: research

Alterations of gut microbiota composition in post-finasteride patients: a pilot study
ConclusionGut microbiota population is altered in PFS patients, suggesting that it might represent a diagnostic marker and a possible therapeutic target for this syndrome. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 19, 2020 Category: Endocrinology Source Type: research

Erosive pustular dermatosis of the scalp
We present a 60-year-old woman with a four-year history of non-healing scalp erosions, progressive skin atrophy, and scarring alopecia despite intravenous antibiotics and intraoperative debridement who improved with systemic glucocorticoids. Our report emphasizes the importance of early recognition of EPDS when delayed wound healing and erosive disease occur in the setting of iatrogenic injury to the scalp. Timely treatment with systemic anti-inflammatory agents is paramount to prevent cicatricial alopecia and mitigate further scalp insult in EPDS. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - September 17, 2020 Category: Dermatology Source Type: research

Female pattern hair loss in men: a distinct clinical variant of androgenetic alopecia
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - September 17, 2020 Category: Dermatology Authors: Karolina L. Kerkemeyer, Lara Trindade de Carvalho, Rebekka Jerjen, Jared John, Rodney D. Sinclair, Joel Pinczewski, Bevin Bhoyrul Source Type: research

Pro-inflammatory V δ1+T-cells infiltrate in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles
Human skin-resident lymphocytes are composed of αβT-cells, NK cells, and γδT-cells [1]. γδT-cells represent a minor T-cell population in human skin ( (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 17, 2020 Category: Dermatology Authors: Youhei Uchida, Jennifer Gherardini, Andreas Schulte-Mecklenbeck, Majid Alam, J érémy Chéret, Alfredo Rossi, Takuro Kanekura, Catharina C. Gros, Akiko Arakawa, Amos Gilhar, Marta Bertolini, Ralf Paus Source Type: research

Prospective observational study of chemotherapy-induced alopecia after sequential FEC  + taxane and the effects of age in breast cancer patients.
CONCLUSIONS: Severe CIA occurred in all 68 patients who received FEC and taxane chemotherapy. The present findings provide the first data demonstrating that age was not associated with the degree or incidence of hair loss, but age affected the recovery from CIA. These results contribute more accurate information provision and insights regarding the proper treatment of CIA. PMID: 32944881 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 17, 2020 Category: Cancer & Oncology Authors: Fujii T, Ichiba K, Honda C, Tokuda S, Nakazawa Y, Ogino M, Kurozumi S, Obayashi S, Yajima R, Shirabe K Tags: Breast Cancer Source Type: research

Pruritic eosinophilic dermatitis in Jersey cows infested with Leptotrombidium spp (Acari: Trombiculidae).
Abstract Eosinophilic dermatitis was observed in skin samples from Jersey cows, sampled in mid-October in south-west France. The inflammatory response was considered to be the result of Trombiculidae bites. Clinical signs were assumed to be due partly to self-trauma and included patchy alopecia with crusted papules; lesions were observed on the jaws, dewlap, perineum and distal limbs. Identified parasites were larvae of Leptotrombidium spp. The lesions had completely self-resolved by December. PMID: 32929760 [PubMed - as supplied by publisher] (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - September 15, 2020 Category: Veterinary Research Authors: Cadiergues MC, Moulin JP, Lucas MN, Dorchies P, Schelcher F Tags: Vet Dermatol Source Type: research

Alopecia and Iron Deficiency: An Interventional Pilot Study in Primary Care to Improve the Request of Ferritin.
Conclusion: Primary care patients with alopecia and laboratory tests request were mainly young female. Our intervention added ferritin when not requested, detecting iron deficiency in 27.9% of women, potentially avoiding the adverse effects of iron deficiency on hair loss. PMID: 32908518 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - September 13, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Low dose IL-2 for treating moderate to severe alopecia areata. A 52 weeks multicenter prospective placebo-controlled study assessing its impact on T regulatory cells and natural killer populations
To the Editor, the treatment of severe Alopecia areata (AA) remains highly challenging. A breakdown of immune privilege of the hair follicle resulting in the development of an admixed immune of antigen presenting cells (APCs), CD4+ and CD8+ T lymphocytes infiltrate is hypothesized to represent an important driver of AA(Pratt et al., 2017). A deficiency in T regulatory cells (Tregs) might facilitate the occurrence of this immune privilege breakdown. A growing corpus of data in animal models but also from blood and skin in AA patients emphasized the likely key role of Tregs in AA pathomechanisms(Conteduca et al., 2014, Hamed...
Source: Journal of Investigative Dermatology - September 13, 2020 Category: Dermatology Authors: Florence Le Duff, Jean-David Bouaziz, Eric Fontas, Michel Ticchioni, Manuelle Viguier, Olivier Dereure, Pascal Reygagne, Henri Montaudi é, Jean-Philippe Lacour, Sandrine Monestier, Marie-Aleth Richard, Thierry Passeron Tags: Letters to the Editor Source Type: research

The Alopecia Areata Consensus of Experts (ACE) Study PART II: Results of an International Expert Opinion on Diagnosis and Laboratory Evaluation for Alopecia Areata
We previously reported The Alopecia Areata Consensus of Experts (ACE) Study: Results of an International Expert Opinion on Treatments for Alopecia Areata (AA). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - September 11, 2020 Category: Dermatology Authors: Nekma Meah, Dmitri Wall, Katherine York, Bevin Bhoyrul, Laita Bokhari, Daniel Asz Sigall, Wilma F. Bergfeld, Regina C. Betz, Ulrike Blume-Peytavi, Valerie Callender, Vijaya Chitreddy, Andrea Combalia, George Cotsarelis, Brittany Craiglow, Jeff Donovan, Sa Source Type: research

Discoid lupus erythematosus in a patient with alopecia totalis.
PMID: 32926840 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - September 11, 2020 Category: Dermatology Authors: Yamamoto M, Yamamoto T Tags: Actas Dermosifiliogr Source Type: research

Characterization and management of hypertrichosis induced by low-dose oral minoxidil in the treatment of hair loss.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - September 10, 2020 Category: Dermatology Authors: Juan Jimenez-Cauhe, David Saceda-Corralo, Rita Rodrigues-Barata, Angela Hermosa-Gelbard, Oscar M. Moreno-Arrones, Rocio Gil-Redondo, Daniel Ortega-Quijano, Diego Fernandez-Nieto, Pedro Jaen-Olasolo, Sergio Va ño-Galvan Source Type: research

Utilization of Crowdfunding for Expenses Related to Medical Hair Loss
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - September 10, 2020 Category: Dermatology Authors: Sheena Desai, Priya Manjaly, Karen J. Lee, Sara J. Li, Cyriac Manjaly, Kathie P. Huang, Arash Mostaghimi Source Type: research

A child with rhombencephalosynapsis, agenesis of the trigeminal ganglion and optic coloboma (without alopecia): a variant of the cerebellotrigeminal dermal dysplasia?
No abstract available (Source: Clinical Dysmorphology)
Source: Clinical Dysmorphology - September 9, 2020 Category: Genetics & Stem Cells Tags: Short Case Reports Source Type: research

Vismodegib-Induced Alopecia: Trichoscopic and Confocal Microscopy Evaluation
Conclusion: Alopecia is one of the most distressing adverse events leading to vismodegib discontinuations. To our knowledge, these are the first descriptions of RCM dermoscopy in vismodegib-induced alopecia. Trichoscopy and confocal microscopy are essential to monitoring vismodegib hair loss and the response to the treatment.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - September 9, 2020 Category: Dermatology Source Type: research

Evaluating Areas of Preferred Hair Loss
This survey study seeks to assess whether there is a preference for location of hair loss on the scalp. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 9, 2020 Category: Dermatology Source Type: research

Hormonal Contraceptives and Dermatology
This article reviews the dermatologic effects, both adverse and beneficial, of combined oral contraceptives (COCs), hormonal intrauterine devices (IUDs), implants, injections, and vaginal rings. Overall, the literature suggests that progesterone-only methods, such as implants and hormonal IUDs, tend to trigger or worsen many conditions, including acne, hirsutism, alopecia, and even rosacea. Therefore, it is worthwhile to obtain detailed medication and contraceptive histories on patients with these conditions. There is sufficient evidence that hormonal contraceptives, particularly COCs and vaginal rings, may effectively tre...
Source: American Journal of Clinical Dermatology - September 7, 2020 Category: Dermatology Source Type: research

Comparison between single- versus double-spin prepared platelet-rich plasma injection in treatment of female pattern hair loss: clinical effect and relation to vascular endothelial growth factor
AbstractPlatelet-rich plasma (PRP) provides a  treatment option for female pattern hair loss (FPHL). However, the most suitable preparation method is not yet clear. The primary aim is to compare between the efficacy of single- versus double-spin PRP preparation injection in the treatment of FPHL, while the secondary aim is to assess the relati onship between vascular endothelial growth factor (VEGF) concentrations in different prepared PRP preparations (pre- and post-activation) and the obtained treatment results. 15 female patients with FPHL were subjected to intradermal injection of double-spin prepared PRP into the...
Source: Archives of Dermatological Research - September 5, 2020 Category: Dermatology Source Type: research

Limbal Stem Cell Dysfunction in Ichthyosis Follicularis, Alopecia, and Photophobia Syndrome
Conclusions: The progressive conjunctivalization, spontaneous epithelial defects, and anterior segment optical coherence tomography features are highly suggestive of limbal stem cell dysfunction in IFAP syndrome. Optimizing the ocular surface is of importance in the management of children with this rare disease. (Source: Cornea)
Source: Cornea - September 4, 2020 Category: Opthalmology Tags: Case Report Source Type: research

Intravenous versus oral cyclophosphamide for lung and/or skin fibrosis in systemic sclerosis: an indirect comparison from EUSTAR and randomised controlled trials.
Authors: Bruni C, Tashkin DP, Steen V, Allanore Y, Distler O, Grotts J, Matucci-Cerinic M, Furst DE, EUSTAR, SLS I & SLS II centres collaborators Abstract OBJECTIVES: Both intravenous (IV) and oral (PO) cyclophosphamide (CYC) showed beneficial effects on skin and lung involvement in systemic sclerosis (SSc) in placebo-controlled randomised clinical trials and observational studies. Our goal was to compare the relative efficacy and safety of PO- versus IV-CYC for treating interstitial lung disease and/or skin involvement in SSc. METHODS: Patients were derived from the EUSTAR centres and the Scleroderma Lung ...
Source: Clinical and Experimental Rheumatology - September 2, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Myasthenia Gravis Coexisting With Primary Sj ögren's Syndrome: Report of Three Cases and Literature Review
Conclusion: The coexistence of SS with MG is quite rare. The onset of MG may occur before or after the diagnosis of SS. Co-morbidity with MG does not seem to adversely affect the course of SS. Thus, controlling the progress of MG is the critical aspect of treatment. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 2, 2020 Category: Neurology Source Type: research

Villainous Hair: Ba(l)d to the Bone - Would they be so evil if they had hair?
Abstract In real-life, the impact of healthy hair on social perception has been extensively studied. But when it comes to the movies, do the hairstyles of villains also portray the physical embodiment of their immoral impulses? The more movies you watch, the easier it is to identify an emerging trend: bald characters are overwhelmingly villains. Alopecia seems to be innately associated with moral decay, as if the characters lack of hair and consequently their humanity was their evilness. At the same time, losing hair appears to be an adequate trigger for driving a character into a pit of immorality and crime. ...
Source: The British Journal of Dermatology - September 2, 2020 Category: Dermatology Authors: Kyriakou G, Drivelou V, Glentis A Tags: Br J Dermatol Source Type: research

Sertoli cell tumor/mixed germ cell-stromal cell tumor as separate neoplasms in a bilaterally cryptorchid dog.
Abstract An 11-year-old miniature poodle dog was presented with bilateral flank alopecia, gynecomastia, severe thrombocytopenia, and preputial edema. Based on characteristic clinical and hematological findings of hyperestrogenism and the presence of a caudal abdominal mass, a Sertoli cell tumor (SCT) was diagnosed. After a platelet concentrate transfusion, the SCT was surgically removed in addition to an atrophied contralateral testicle containing a mixed germ cell-stromal cell tumor. Recovery was uneventful. This combination of different neoplasms in separate testicles has yet to be documented. Key clinical messa...
Source: The Canadian Veterinary Journal - September 1, 2020 Category: Veterinary Research Authors: DeForge TL Tags: Can Vet J Source Type: research

Chronic ulcerative stomatitis: a case report
A 55-year-old Caucasian male patient with difficulty eating due to painful intra-oral ulcers for approximately 2 weeks was seen at the clinic. In the anamnesis he reported hepatitis C (genotype 3 A) with sustained virologic response for 20 years, rheumatoid arthritis for 5 years, thrombocytopenia for 2 years, and hyperuricemia. On physical examination, alopecia and brittle, scaly, and dystrophic nails were observed. The intra-oral examination revealed the presence of multiple erosive and ulcerated lesions, surrounded by white hyperkeratotic striate resembling those of erosive oral lichen planus. (Source: Oral Surgery, Oral...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 1, 2020 Category: ENT & OMF Authors: BRUNA DE OLIVEIRA RECH, JEFFERSON DA ROCHA TEN ÓRIO, PAULO HENRIQUE BRAZ-SILVA, KAREM LOPEZ ORTEGA Tags: 20190292 Source Type: research

Association of Frontal Fibrosing Alopecia with Facial Papules and Lichen Planus Pigmentosus in a Caucasian Woman
Conclusion: The peculiarity of our report is represented by the triple association of FFA, FP, and LPPigm in a Caucasian skin type III woman, as it has been rarely reported. Clinicians should be aware of this association also in subjects with phototype ≤III, as its recognition may be useful for diagnostic and prognostic purposes: the observation of LPPigm of the face may suggest to check for early FFA, and in case of FFA associated with FP, a poorer FFA prognosis may likely be expected.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - August 31, 2020 Category: Dermatology Source Type: research

[Hyperandrogenism, adrenal dysfunction, and hirsutism].
Authors: Makrantonaki E, Zouboulis CC Abstract Hyperandrogenism or hyperandrogenemia are medical conditions characterized by excessive levels of androgens in the periphery or systemically. Clinical manifestations of hyperandrogenism include hirsutism, seborrhea, acne, androgenetic alopecia, and virilization. Hirsutism, defined as excessive growth of terminal hair in women in a male-like pattern, is the most commonly used clinical diagnostic criterion of hyperandrogenism and is determined by using a standardized scoring system of hair growth. Acne and alopecia are further common androgenic skin changes and...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - August 30, 2020 Category: Dermatology Tags: Hautarzt Source Type: research

Outcome of FOLFOX and Modified DCF Chemotherapy Regimen in Patients with Advanced Gastric Adenocarcinoma.
CONCLUSION: The results of current study showed that in patients with advanced gastric adenocarcinoma, FOLFOX regimen compared to mDCF regimen have similar ORR, OS and PFS. Toxicity rate are also lower in FOLFOX group, thus it seems a better regimen for chemotherapy.. PMID: 32856863 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Alopecia following cranial stereotactic radiosurgery: A comprehensive review of the literature
Publication date: October 2020Source: Journal of Clinical Neuroscience, Volume 80Author(s): Swathi Chidambaram, Dominique Macaluso, Susan C. Pannullo (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - August 27, 2020 Category: Neuroscience Source Type: research

Unusual Presentation of a Denys-Drash Syndrome Girl with Undisclosed Assumption of Biotin.
We describe a 46,XX girl with Denys-Drash syndrome (DDS), showing both kidney disease and genital abnormalities, in whom a misdiagnosis of hyperandrogenism was made. A 15 year-old girl was affected by neonatal nephrotic syndrome, progressing to end stage kidney failure. Hair loss and voice deepening were noted during puberty. Pelvic ultrasound and MRI showed utero-tubaric agenesis, vaginal atresia and urogenital sinus, with inguinal gonads. Gonadotrophin and estradiol levels were normal, but testosterone levels increased up to 285 ng/dL at Tanner stage 3. She underwent prophylactic gonadectomy and histopathology reported f...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - August 27, 2020 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

NISCH syndrome: An extremely rare cause of neonatal cholestasis
The NISCH syndrome is an extremely rare autosomal recessive syndrome characterized by neonatal ichthyosis and sclerosing cholangitis.1 First reported in 2002 in 2 inbred kindreds of Moroccan origin,2 to date it has only been described in 18 patients from 9 different families (Table  S1). Associated clinical features include scarring alopecia, scalp hypotrichosis, enamel hypoplasia and in individual cases, mental retardation and bilateral uveal synechiae.3,4 In an effort to expand our knowledge of this syndrome, we contribute with this clinical case and briefly summarize the c urrent knowledge on this entity. (Source: ...
Source: Journal of Hepatology - August 27, 2020 Category: Gastroenterology Authors: Ana Carolina Izurieta Pacheco, Laura Monfort Carretero, Carolina Prat Torres, Alfredo Garc ía-Alix Pérez, Cristina Molera Busoms Tags: Letter to the Editor Source Type: research

ONS Guidelines ™ for Cancer Treatment-Related Skin Toxicity.
ONS Guidelines™ for Cancer Treatment-Related Skin Toxicity. Oncol Nurs Forum. 2020 Sep 01;47(5):539-556 Authors: Williams LA, Ginex PK, Ebanks GL, Ganstwig K, Ciccolini K, Kwong BK, Robison J, Shelton G, Strelo J, Wiley K, Maloney C, Moriarty KA, Vrabel M, Morgan RL Abstract BACKGROUND: Management of cancer treatment-related skin toxicities can minimize treatment disruptions and improve patient well-being. OBJECTIVES: This guideline aims to support patients and clinicians in decisions regarding management of cancer treatment-related skin toxicities. METHODS: A panel developed a guideli...
Source: Oncology Nursing Forum - August 26, 2020 Category: Nursing Authors: Williams LA, Ginex PK, Ebanks GL, Ganstwig K, Ciccolini K, Kwong BK, Robison J, Shelton G, Strelo J, Wiley K, Maloney C, Moriarty KA, Vrabel M, Morgan RL Tags: Oncol Nurs Forum Source Type: research

Targeted Therapy- and Chemotherapy-Associated Skin Toxicities: Systematic Review and Meta-Analysis.
Abstract PROBLEM IDENTIFICATION: Preventing and managing skin toxicities can minimize treatment disruptions and improve well-being. This systematic review aimed to evaluate the effectiveness of interventions for the prevention and management of cancer treatment-related skin toxicities. LITERATURE SEARCH: The authors systematically searched for comparative studies published before April 1, 2019. Study selection and appraisal were conducted by pairs of independent reviewers. DATA EVALUATION: The random-effects model was used to conduct meta-analysis when appropriate. SYNTHESIS: 39 studies (6,006 patie...
Source: Oncology Nursing Forum - August 26, 2020 Category: Nursing Authors: Ding J, Farah MH, Nayfeh T, Malandris K, Manolopoulos A, Ginex PK, Hasan B, Dunnack H, Abd-Rabu R, Rajjoub M, Prokop L, Morgan RL, Murad MH Tags: Oncol Nurs Forum Source Type: research

Frontal Fibrosing Alopecia and Autoimmune Disorders in a Hispanic Female
Frontal fibrosing alopecia (FFA) is a cicatricial alopecia characterized by hairline recession. Multiple autoimmune pathologies have been reported in patients with FFA. Despite the fact that FFA etiology remains unknown, there has been described an association with autoimmune disorders probably caused by an altered activity of cytotoxic CD8 T lymphocytes. Moreover, other autoimmune pathologies develop TH1 and TH17 response. Genetics could be responsible, in part, for the role of multiple simultaneous autoimmune disorders. Herein, we describe a case of a female patient with vitiligo, lichen sclerosus, and autoimmune hypothy...
Source: Skin Appendage Disorders - August 26, 2020 Category: Dermatology Source Type: research

Reply to “Comment on androgenetic alopecia present in the majority of patients hospitalized with COVID-19”
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 26, 2020 Category: Dermatology Authors: Carlos G. Wambier Source Type: research

Comment on “Androgenetic alopecia present in the majority of patients hospitalized with COVID-19”
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 26, 2020 Category: Dermatology Authors: Domen Bukovac, Ur ška Makše Source Type: research

Cicatricial Alopecia Related to Folliculotropic Mycosis Fungoides
AbstractFolliculotropic mycosis fungoides (FMF) is a particular subtype of mycosis fungoides (MF), characterized by an infiltration of neoplastic CD4+  T cells in the epidermis which can spread to all follicular structures, sebaceous glands, sweat glands and hair follicles. Clinically, FMF can exhibit various cutaneous symptoms. However, these symptoms often occur on the scalp, face and neck, which are rarely affected by conventional MF. We repo rt cicatricial alopecia in a patient with FMF as alopecia lymphomatica. This peculiar symptom should be kept in mind as a critical differential diagnosis of scarring alopeci...
Source: Dermatology and Therapy - August 24, 2020 Category: Dermatology Source Type: research

Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia
Saw palmetto (SP), a botanical extract with antiandrogenic properties, has gained commercial popularity for its purported benefits on hair regrowth. To summarize published evidence on the efficacy, safety, and tolerability of supplements containing SP in the treatment of alopecia, we conducted a PubMed, Google Scholar, and Cochrane database search using the following terms: (saw palmetto and hair loss), (saw palmetto and androgenetic alopecia), and (saw palmetto and natural supplement and alopecia). Five randomized clinical trials (RCTs) and 2 prospective cohort studies demonstrated positive effects of topical and oral sup...
Source: Skin Appendage Disorders - August 23, 2020 Category: Dermatology Source Type: research

Association Between 5-Alpha Reductase Inhibitor Use and The Risk of Depression: A Meta-Analysis.
Abstract PURPOSE: To explore the association between 5α-reductase inhibitors (5ARIs) use and risk of depression based on published literature through a meta-analysis. MATERIALS AND METHODS: A comprehensive literature search was conducted by searching Pubmed, Embase, Cochrane Library, CBM, CNKI and VIP databases up to June, 2019. Summarized risk ratios (RRs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of association between 5ARIs and depression. Subgroup analyses were performed according to population, 5ARI types, degree of depression, and publication date. Registered in ...
Source: Urology Journal - August 23, 2020 Category: Urology & Nephrology Authors: Deng T, Duan X, He Z, Zhao Z, Zeng G Tags: Urol J Source Type: research

CARASIL; The backache, baldness, brain attack syndrome: The Indian scenario
Sagar Badachi, Saji K John, Mithun Sekhar, Thomas MathewAnnals of Indian Academy of Neurology 2020 23(4):559-561 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - August 21, 2020 Category: Neurology Authors: Sagar Badachi Saji K John Mithun Sekhar Thomas Mathew Source Type: research

Risk Factors for Frontal Fibrosing Alopecia: a case-control study in a multiracial population
According to this study, FFA was associated with moisturizers, ordinary (non-dermatologic) facial soap, and formalin hair straightening. Use anti-residue / clarifying shampoo and smoking were suggested as protective factors. FFA was not associated with sunscreens. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2020 Category: Dermatology Authors: Paulo M üller Ramos, Alessandra Anzai, Bruna Duque-Estrada, Debora Cadore Farias, Daniel Fernandes Melo, Fabiane Mulinari-Brenner, Giselle Martins Pinto, Leonardo Spagnol Abraham, Leopoldo Duailib Nogueira Santos, Rodrigo Pirmez, Hélio Amante Miot Source Type: research