Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Histological features of follicular mycosis fungoides. (A-B) Dense superficial and deep dermal lymphocytic infiltrate with a predominantly perifollicular/folliculocentric distribution extending into the mid-dermis. Atypical lymphocytes are located along the basal cell layer of the hair follicle epithelium. Some neoplastic lymphocytes are surrounded by a halo. Although there is epidermal thinning, there is no atypia or epidermotropism, or Pautrier microabscesses. The interfollicular epidermis is not involved. (Hematoxylin and eosin staining, original magnification, A:x20, B:x40). (C-D) Exocytosis of small and medium-sized h...
Source: Clinical Case Reports - April 5, 2024 Category: General Medicine Authors: Majed Saleh Aldayhum,
Mohammed Saad Alshahrani,
Mahmoud Rezk A. Hussein,
Abdulmajeed Saad Alshahrani,
Toka M. R. Hussein Tags: CASE REPORT Source Type: research
Distribution of < em > TGFBI < /em > variants in patients with early onset glaucoma
CONCLUSIONS: The possibility that variations in the TGFBI gene could have a possible role in the pathogenesis of congenital and juvenile onset open-angle glaucomas needs further evaluation.PMID:38577561 | PMC:PMC10994680 (Source: Molecular Vision)
Source: Molecular Vision - April 5, 2024 Category: Molecular Biology Authors: Viney Gupta Arnav Panigrahi Bindu I Somarajan Shikha Gupta Koushik Tripathy Abhishek Singh Anshul Sharma Radhika Tandon Dibyabhaba Pradhan Arundhati Sharma Tushar Kushwaha Krishna K Inampudi Source Type: research
Minoxidil Nanosuspension-Loaded Dissolved Microneedles for Hair Regrowth
The objective of this study was to evaluate the dermal delivery of MIN by utilizing dissolved microneedles (MNs) loaded with MIN nanosuspension (MIN-NS) for hair regrowth. MIN-NS was prepared by the solvent-antisolvent precipitation technique. The particle size of MIN-NS was 226.7 ± 9.3 nm with a polydispersity index of 0.29 ± 0.17 and a zeta potential of -29.97 ± 1.23 mV. An optimized formulation of MIN-NS was selected, freeze-dried, and loaded into MNs fabricated with sodium carboxymethyl cellulose (Na CMC) polymeric solutions (MIN-NS-loaded MNs). MNs were evaluated for morphology, dissolution rate, skin insertion, dr...
Source: AAPS PharmSciTech - April 5, 2024 Category: Drugs & Pharmacology Authors: Rania Hamed Hebah F I Alhadidi Source Type: research
Distribution of < em > TGFBI < /em > variants in patients with early onset glaucoma
CONCLUSIONS: The possibility that variations in the TGFBI gene could have a possible role in the pathogenesis of congenital and juvenile onset open-angle glaucomas needs further evaluation.PMID:38577561 | PMC:PMC10994680 (Source: Molecular Vision)
Source: Molecular Vision - April 5, 2024 Category: Molecular Biology Authors: Viney Gupta Arnav Panigrahi Bindu I Somarajan Shikha Gupta Koushik Tripathy Abhishek Singh Anshul Sharma Radhika Tandon Dibyabhaba Pradhan Arundhati Sharma Tushar Kushwaha Krishna K Inampudi Source Type: research
Minoxidil Nanosuspension-Loaded Dissolved Microneedles for Hair Regrowth
The objective of this study was to evaluate the dermal delivery of MIN by utilizing dissolved microneedles (MNs) loaded with MIN nanosuspension (MIN-NS) for hair regrowth. MIN-NS was prepared by the solvent-antisolvent precipitation technique. The particle size of MIN-NS was 226.7 ± 9.3 nm with a polydispersity index of 0.29 ± 0.17 and a zeta potential of -29.97 ± 1.23 mV. An optimized formulation of MIN-NS was selected, freeze-dried, and loaded into MNs fabricated with sodium carboxymethyl cellulose (Na CMC) polymeric solutions (MIN-NS-loaded MNs). MNs were evaluated for morphology, dissolution rate, skin insertion, dr...
Source: AAPS PharmSciTech - April 5, 2024 Category: Drugs & Pharmacology Authors: Rania Hamed Hebah F I Alhadidi Source Type: research
Distribution of < em > TGFBI < /em > variants in patients with early onset glaucoma
CONCLUSIONS: The possibility that variations in the TGFBI gene could have a possible role in the pathogenesis of congenital and juvenile onset open-angle glaucomas needs further evaluation.PMID:38577561 | PMC:PMC10994680 (Source: Molecular Vision)
Source: Molecular Vision - April 5, 2024 Category: Molecular Biology Authors: Viney Gupta Arnav Panigrahi Bindu I Somarajan Shikha Gupta Koushik Tripathy Abhishek Singh Anshul Sharma Radhika Tandon Dibyabhaba Pradhan Arundhati Sharma Tushar Kushwaha Krishna K Inampudi Source Type: research
Minoxidil Nanosuspension-Loaded Dissolved Microneedles for Hair Regrowth
The objective of this study was to evaluate the dermal delivery of MIN by utilizing dissolved microneedles (MNs) loaded with MIN nanosuspension (MIN-NS) for hair regrowth. MIN-NS was prepared by the solvent-antisolvent precipitation technique. The particle size of MIN-NS was 226.7 ± 9.3 nm with a polydispersity index of 0.29 ± 0.17 and a zeta potential of -29.97 ± 1.23 mV. An optimized formulation of MIN-NS was selected, freeze-dried, and loaded into MNs fabricated with sodium carboxymethyl cellulose (Na CMC) polymeric solutions (MIN-NS-loaded MNs). MNs were evaluated for morphology, dissolution rate, skin insertion, dr...
Source: AAPS PharmSciTech - April 5, 2024 Category: Drugs & Pharmacology Authors: Rania Hamed Hebah F I Alhadidi Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
