Transient stimulation of TRPMLs enhance the functionality of hDPCs and facilitate hair growth in mice
Cell Signal. 2024 Apr 9;119:111167. doi: 10.1016/j.cellsig.2024.111167. Online ahead of print.ABSTRACTAutophagy is essential for eliminating aging and organelle damage that maintaining cellular homeostasis. However, the dysfunction of autophagy has been proven in hair loss such as AGA. Despite the crucial role of TRPML channels in regulating autophagy, their specific function in hair growth remains unclarified. To investigate the biological functions and associated molecular mechanisms of TRPMLs in hair growth, Animal experiments were conducted to confirm the function of TRLMLs activation in promoting hair growth. Subseque...
Source: Cellular Signalling - April 11, 2024 Category: Cytology Authors: Jiayi Sun Hongyan Zhang Bo Xie Yuqing Shen Yuqi Zhu Wen Xu Beilei Zhang Xiuzu Song Source Type: research
Thoughts on "Dermatologists' Knowledge, Attitude, and Practice Pattern Toward Low-Dose Oral Minoxidil in Hair Loss in Saudi Arabia" [Letter]
Clin Cosmet Investig Dermatol. 2024 Apr 6;17:783-784. doi: 10.2147/CCID.S470453. eCollection 2024.NO ABSTRACTPMID:38601954 | PMC:PMC11005843 | DOI:10.2147/CCID.S470453 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 11, 2024 Category: Dermatology Authors: Sabrina Shahid Mahdi Sadeghi Source Type: research
Transient stimulation of TRPMLs enhance the functionality of hDPCs and facilitate hair growth in mice
Cell Signal. 2024 Apr 9;119:111167. doi: 10.1016/j.cellsig.2024.111167. Online ahead of print.ABSTRACTAutophagy is essential for eliminating aging and organelle damage that maintaining cellular homeostasis. However, the dysfunction of autophagy has been proven in hair loss such as AGA. Despite the crucial role of TRPML channels in regulating autophagy, their specific function in hair growth remains unclarified. To investigate the biological functions and associated molecular mechanisms of TRPMLs in hair growth, Animal experiments were conducted to confirm the function of TRLMLs activation in promoting hair growth. Subseque...
Source: Cellular Signalling - April 11, 2024 Category: Cytology Authors: Jiayi Sun Hongyan Zhang Bo Xie Yuqing Shen Yuqi Zhu Wen Xu Beilei Zhang Xiuzu Song Source Type: research
Oral Minoxidil vs Topical Minoxidil for Male Androgenetic Alopecia
This randomized clinical trial compares the efficacy, safety, and tolerability of daily oral minoxidil, 5 mg, with twice-daily topical minoxidil, 5%, for 24 weeks in the treatment of male androgenetic alopecia. (Source: JAMA Dermatology)
Source: JAMA Dermatology - April 10, 2024 Category: Dermatology Source Type: research
Current Diagnostic and Therapeutic Practices in Alopecia Areata in Two Mediterranean Countries: A Survey-Based Study
ConclusionsOur results highlight that management of AA, in terms of diagnosis and treatment, is still challenging. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 10, 2024 Category: Dermatology Source Type: research
Aged polystyrene microplastics exacerbate alopecia associated with tight junction injuries and apoptosis via oxidative stress pathway in skin
In this study, we have examined the effects of two types of polystyrene MPs (pristine and aged) on skin and hair follicle damage in mice. UV irradiation changed the chemical and physical properties of the aged MPs, including functional groups, surface roughness, and contact angles. In both in vivo and in vitro experiments, skin and cell injuries related to oxidative stress, apoptosis, tight junctions (TJs), alopecia, mitochondrial dysfunction, and other damages were observed. Mechanistically, MPs and aged MPs can induce TJs damage via the oxidative stress pathway and inhibition of antioxidant-related proteins, and this can...
Source: Environment International - April 9, 2024 Category: Environmental Health Authors: Qian Li Lehua Jiang Jianhai Feng Xinhui Wang Xusheng Wang Xuejuan Xu Weiwei Chu Source Type: research
Aged polystyrene microplastics exacerbate alopecia associated with tight junction injuries and apoptosis via oxidative stress pathway in skin
In this study, we have examined the effects of two types of polystyrene MPs (pristine and aged) on skin and hair follicle damage in mice. UV irradiation changed the chemical and physical properties of the aged MPs, including functional groups, surface roughness, and contact angles. In both in vivo and in vitro experiments, skin and cell injuries related to oxidative stress, apoptosis, tight junctions (TJs), alopecia, mitochondrial dysfunction, and other damages were observed. Mechanistically, MPs and aged MPs can induce TJs damage via the oxidative stress pathway and inhibition of antioxidant-related proteins, and this can...
Source: Environment International - April 9, 2024 Category: Environmental Health Authors: Qian Li Lehua Jiang Jianhai Feng Xinhui Wang Xusheng Wang Xuejuan Xu Weiwei Chu Source Type: research
Letter from the editor: Making sense of central centrifugal cicatricial alopecia (CCCA)
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 9, 2024 Category: Dermatology Authors: Dirk M. Elston, Boni E. Elewski, Susan Taylor Source Type: research
Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Clin Case Rep. 2024 Apr 5;12(4):e8731. doi: 10.1002/ccr3.8731. eCollection 2024 Apr.ABSTRACTKEY CLINICAL MESSAGE: F-MF is a rare non-classic variant of MF. In the case of hair loss, this should be a diagnostic consideration. The essence of the diagnosis of F-MF is a careful medical history, physical examination, and a combination of immunohistological and molecular analyses (Cureus. 2022; 14:e21231, Ann Saudi Med. 2012; 32:283, Oman Med J. 2012; 27:134, Int J Dermatol. 2016; 55:1396, Saudi Med J. 2018; 39:994 and Case Rep Oncol. 2018; 11:436).ABSTRACT: Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with mult...
Source: Ann Oncol - April 8, 2024 Category: Cancer & Oncology Authors: Majed Saleh Aldayhum Mohammed Saad Alshahrani Mahmoud Rezk A Hussein Abdulmajeed Saad Alshahrani Toka M R Hussein Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
