Minoxidil Nanosuspension-Loaded Dissolved Microneedles for Hair Regrowth
The objective of this study was to evaluate the dermal delivery of MIN by utilizing dissolved microneedles (MNs) loaded with MIN nanosuspension (MIN-NS) for hair regrowth. MIN-NS was prepared by the solvent-antisolvent precipitation technique. The particle size of MIN-NS was 226.7 ± 9.3 nm with a polydispersity index of 0.29 ± 0.17 and a zeta potential of -29.97 ± 1.23 mV. An optimized formulation of MIN-NS was selected, freeze-dried, and loaded into MNs fabricated with sodium carboxymethyl cellulose (Na CMC) polymeric solutions (MIN-NS-loaded MNs). MNs were evaluated for morphology, dissolution rate, skin insertion, dr...
Source: AAPS PharmSciTech - April 5, 2024 Category: Drugs & Pharmacology Authors: Rania Hamed Hebah F I Alhadidi Source Type: research
Distribution of < em > TGFBI < /em > variants in patients with early onset glaucoma
CONCLUSIONS: The possibility that variations in the TGFBI gene could have a possible role in the pathogenesis of congenital and juvenile onset open-angle glaucomas needs further evaluation.PMID:38577561 | PMC:PMC10994680 (Source: Molecular Vision)
Source: Molecular Vision - April 5, 2024 Category: Molecular Biology Authors: Viney Gupta Arnav Panigrahi Bindu I Somarajan Shikha Gupta Koushik Tripathy Abhishek Singh Anshul Sharma Radhika Tandon Dibyabhaba Pradhan Arundhati Sharma Tushar Kushwaha Krishna K Inampudi Source Type: research
Minoxidil Nanosuspension-Loaded Dissolved Microneedles for Hair Regrowth
The objective of this study was to evaluate the dermal delivery of MIN by utilizing dissolved microneedles (MNs) loaded with MIN nanosuspension (MIN-NS) for hair regrowth. MIN-NS was prepared by the solvent-antisolvent precipitation technique. The particle size of MIN-NS was 226.7 ± 9.3 nm with a polydispersity index of 0.29 ± 0.17 and a zeta potential of -29.97 ± 1.23 mV. An optimized formulation of MIN-NS was selected, freeze-dried, and loaded into MNs fabricated with sodium carboxymethyl cellulose (Na CMC) polymeric solutions (MIN-NS-loaded MNs). MNs were evaluated for morphology, dissolution rate, skin insertion, dr...
Source: AAPS PharmSciTech - April 5, 2024 Category: Drugs & Pharmacology Authors: Rania Hamed Hebah F I Alhadidi Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Pediatric Dermatology for People of Color
Pediatr Ann. 2024 Apr;53(4):e146-e151. doi: 10.3928/19382359-20240205-07. Epub 2024 Apr 1.ABSTRACTWhen evaluating pediatric patients of color, it is essential to consider the unique diagnostic and treatment factors that apply to this population. Certain dermatologic conditions are more common in these patients, including postinflammatory hyperpigmentation, pityriasis alba, progressive macular hypomelanosis, tinea capitis, traction alopecia, keloids, hypertrophic scars, pseudofolliculitis barbae, acne keloidalis nuchae, and hidradenitis suppurativa. Furthermore, conditions such as vitiligo are more noticeable in people of c...
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Muayad M Shahin Henry T Quach Kalyani S Marathe Source Type: research
Scarring alopecia from cutaneous sarcoidosis of the scalp
Sarcoidosis Vasc Diffuse Lung Dis. 2024 Mar 26;41(1):e2024018. doi: 10.36141/svdld.v41i1.15660.NO ABSTRACTPMID:38567553 | DOI:10.36141/svdld.v41i1.15660 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Michelle Sikora Chinemelum Obijiofor Kristen Lo Sicco Avrom Caplan Source Type: research
Patient-Reported Burden of Severe Alopecia Areata: First Results from the Multinational Alopecia Areata Unmet Need Survey
CONCLUSION: The study emphasizes the substantial burden, including impaired quality of life and psychological well-being, of severe AA on the lives of surveyed participants. The findings highlight the importance of comprehensive disease management strategies that address both physical and psychosocial aspects of AA.PMID:38566887 | PMC:PMC10986409 | DOI:10.2147/CCID.S445646 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 3, 2024 Category: Dermatology Authors: Anthony Bewley Ignasi Figueras-Nart Jainzhong Zhang Mariana Guerreiro Nicole Tietz Sami Chtourou Frederick Durand Ulrike Blume-Peytavi Source Type: research
Scarring alopecia from cutaneous sarcoidosis of the scalp
Sarcoidosis Vasc Diffuse Lung Dis. 2024 Mar 26;41(1):e2024018. doi: 10.36141/svdld.v41i1.15660.NO ABSTRACTPMID:38567553 | DOI:10.36141/svdld.v41i1.15660 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Michelle Sikora Chinemelum Obijiofor Kristen Lo Sicco Avrom Caplan Source Type: research
Patient-Reported Burden of Severe Alopecia Areata: First Results from the Multinational Alopecia Areata Unmet Need Survey
CONCLUSION: The study emphasizes the substantial burden, including impaired quality of life and psychological well-being, of severe AA on the lives of surveyed participants. The findings highlight the importance of comprehensive disease management strategies that address both physical and psychosocial aspects of AA.PMID:38566887 | PMC:PMC10986409 | DOI:10.2147/CCID.S445646 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 3, 2024 Category: Dermatology Authors: Anthony Bewley Ignasi Figueras-Nart Jainzhong Zhang Mariana Guerreiro Nicole Tietz Sami Chtourou Frederick Durand Ulrike Blume-Peytavi Source Type: research
