Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor

Conclusions/interpretationWe demonstrated that ablation of MFF in liver provoked ER stress and reduced hepatic TG secretion in vivo and in vitro. Moreover,MffLiKO mice were more susceptible to HFD-induced NASH phenotype than control mice, partly because of ER stress-induced apoptosis of hepatocytes and suppression of TG secretion from hepatocytes. This study provides evidence for the role of mitochondrial fission in the development of NASH.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research