Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor
Conclusions/interpretationWe demonstrated that ablation of MFF in liver provoked ER stress and reduced hepatic TG secretion in vivo and in vitro. Moreover,MffLiKO mice were more susceptible to HFD-induced NASH phenotype than control mice, partly because of ER stress-induced apoptosis of hepatocytes and suppression of TG secretion from hepatocytes. This study provides evidence for the role of mitochondrial fission in the development of NASH.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research
More News: Alcoholism | Diets | Endocrinology | Fatty Liver Disease (FLD) | Genetics | High Fat | Liver | Liver Disease | Mitochondrial Disease | Non-alcoholic Fatty Liver Diseases (NAFLD) | Nutrition | Study | Urology & Nephrology