O-077 Cancer risk in a nationwide cohort of children and young adults conceived by assisted reproductive technology in 1983-2012

AbstractStudy questionAre children conceived by assisted reproductive technology (ART) at increased cancer risk, compared with the general population and with non-ART conceived offspring from subfertile women?Summary answerOverall cancer risk was not increased in ART-conceived offspring compared with non-ART conceived offspring from subfertile women (median follow-up, 17 years).What is known alreadyThere is growing evidence that ART procedures could perturb epigenetic processes during the pre-implantation period. Although the results of most studies are reassuring for children born after in vitro fertilization (IVF), recent studies showed (non-)significantly increased cancer risks after intracytoplasmic sperm injection (ICSI) and frozen embryo transfer (FET). Since the proportion of children born after these techniques increased dramatically over the past decades, it is important from a public health perspective to investigate cancer risk after ICSI and FET in larger studies.Study design, size, durationData were used from the OMEGA-cohort, a historical nationwide cohort with prospective follow-up in the Netherlands. Offspring of women who were treated in one of the 13 IVF clinics or 2 regional fertility centers between 1983-2012 were included. Of 98,165 live-born children, 53,154 were ART-conceived and 45,211 were non-ART conceived (conceived naturally with or without ovarian hyperstimulation) by subfertile women.Participants/materials, setting, methodsData on type of fertili...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research