Molecules, Vol. 26, Pages 3943: CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways

Molecules, Vol. 26, Pages 3943: CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways Molecules doi: 10.3390/molecules26133943 Authors: Seyed Mohammad Gheibihayat Ricardo Cabezas Nikita G. Nikiforov Tannaz Jamialahmadi Thomas P. Johnston Amirhossein Sahebkar CD47 is a receptor belonging to the immunoglobulin (Ig) superfamily and broadly expressed on cell membranes. Through interactions with ligands such as SIRPα, TSP-1, integrins, and SH2-domain bearing protein tyrosine phosphatase substrate-1 (SHPS-1), CD47 regulates numerous functions like cell adhesion, proliferation, apoptosis, migration, homeostasis, and the immune system. In this aspect, previous research has shown that CD47 modulates phagocytosis via macrophages, the transmigration of neutrophils, and the activation of T-cells, dendritic cells, and B-cells. Moreover, several studies have reported the increased expression of the CD47 receptor in a variety of diseases, including acute lymphoblastic leukemia (ALL), chronic myeloid leukemia, non-Hodgkin’s lymphoma (NHL), multiple myeloma (MM), bladder cancer, acute myeloid leukemia (AML), Gaucher disease, Multiple Sclerosis and stroke among others. The ubiquitous expression of the CD47 cell receptor on most resident cells of the CNS has previously been established through different methodologies. However, there is little information concerning its precise functions in the development of different neurodegenerative...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research