A Blind Patient Regained Partial Sight in a Breakthrough Study, Offering Hope to Millions

The darkness descends slowly for people with retinitis pigmentosa (RP), a degenerative eye disease that affects 2 million people worldwide. The condition is typically diagnosed in childhood or adolescence, but it can take until middle age before a person’s vision has deteriorated severely enough that they are fully or effectively blind. When the lights finally do go out, however, they stay out. Or that’s the way things used to be. In a breakthrough study published today in Nature Medicine, investigators report a relatively simple yet remarkably effective way to restore partial vision to RP patients—one that, with further study, may soon have wide application. The key lies in the rod-shaped photoreceptors that principally govern peripheral vision and the cone-shaped receptors that give us our central view of the world. In people with RP, mutations in more than 70 genes cause slow deterioration of the rods, leading to tunnel vision, and later the cones, leading to blindness. Light still streams into the eye through the unaffected lens, and that light could still make its way to the brain via the optic nerve. But the retina, which lies between the two, no longer works. A team of researchers, led by Dr. José-Alain Sahel, professor of ophthalmology at Sorbonne University and the University of Pittsburgh, however, thought they might have a way to bring the retina back into the game: ChrimsonR, a protein that opens electrical channels in neurons and makes t...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized embargoed study Innovation Source Type: news

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Presentation Description: Diabetic retinopathy is the leading cause of blindness in working age adults in the United States. It is challenging to address in both rural and urban underserved settings, which suffer from shortages of eye specialists. This talk will describe the approach taken to address this condition in a medically underserved area (South Los Angeles) by researchers in the Center for Biomedical Informatics at Charles R. Drew University of Medicine and Science, using telehealth and machine learning on data from patient electronic health records. Speaker Bio: Omolola Ogunyemi, PhD, FACMI is the Director of ...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
In conclusion, our findings indicated a higher degree of functional adaptation between the morphological structure of the eye and the surrounding environmental conditions.PMID:34523760 | DOI:10.1002/jemt.23934
Source: Cell Research - Category: Cytology Authors: Source Type: research
In conclusion, TA may be considered a useful therapeutic agent for treating TGF‑β2‑associated intraocular angiogenesis and tissue remodeling, the underlying mechanism of which may involve the ERK and p38 MAPK signaling pathways.PMID:34523693 | DOI:10.3892/mmr.2021.12442
Source: Molecular Medicine Reports - Category: Molecular Biology Authors: Source Type: research
Conclusion: The plasma levels of citrulline, creatinine, arginine, and aminoadipic acid were significantly changed in ROP patients. These metabolites could be considered potential biomarkers of ROP, and their related metabolic pathways might be involved in ROP pathogenesis.PMID:34522185 | PMC:PMC8436098 | DOI:10.7150/ijms.63603
Source: International Journal of Medical Sciences - Category: Biomedical Science Authors: Source Type: research
Conclusions: Our findings indicate that AAV2 and AAV6.2 may be the best choices for AAV-mediated gene delivery into intra-articular cartilage tissue. These AAV vectors hold the potential to be of use in clinical applications to prevent OA progression if appropriate therapeutic genes are inserted into the vector.PMID:34522160 | PMC:PMC8436087 | DOI:10.7150/ijms.56760
Source: International Journal of Medical Sciences - Category: Biomedical Science Authors: Source Type: research
HIV-1 broadly neutralizing antibodies (bNAbs) targeting the viral envelope have shown significant promise in both HIV prevention and viral clearance, including pivotal results against sensitive strains in the recent Antibody Mediated Prevention (AMP) trial. Studies of bNAb passive transfer in infected patients have demonstrated transient reduction of viral load at high concentrations that rebounds as bNAb is cleared from circulation. While neutralization is a crucial component of therapeutic efficacy, numerous studies have demonstrated that bNAbs can also mediate effector functions, such as antibody-dependent cellular cyto...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractChemerin is a multifunctional protein initially characterized in our laboratory as a chemoattractant factor for leukocyte populations. Its main functional receptor is CMKLR1. We identified previously chemerin as an anti-tumoral factor inhibiting the vascularization of tumor grafts. We show here that overexpression of bioactive chemerin in mice results in a reduction of the density of the retinal vascular network during its development and in adults. Chemerin did not affect vascular sprouting during the post-natal development of the network, but rather promoted endothelial cell apoptosis and vessel pruning. This phe...
Source: Angiogenesis - Category: Molecular Biology Source Type: research
g Liang Segmentation of retinal vessels is a critical step for the diagnosis of some fundus diseases. Methods: To further enhance the performance of vessel segmentation, we propose a method based on a gated skip-connection network with adaptive upsampling (GSAU-Net). In GSAU-Net, a novel skip-connection with gating is first utilized in the extension path, which facilitates the flow of information from the encoder to the decoder. Specifically, we used the gated skip-connection between the encoder and decoder to gate the lower-level information from the encoder. In the decoding phase, we used an adaptive upsampling to re...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Genes, Vol. 12, Pages 1414: Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel–Lindau Disease Genes doi: 10.3390/genes12091414 Authors: Hugh Furness Louay Salfity Johanna Devereux Dorothy Halliday Helen Hanson Deborah M. Ruddy UK VHL Study Group UK VHL Study Group Neha Shah George Sultana Emma R. Woodward Richard N. Sandford Katie M. Snape Eamonn R. Maher Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haem...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
or Bendik Vitamins and bioactives, which are constituents of the food chain, modulate T lymphocyte proliferation and differentiation, antibody production, and prevent inflammation and autoimmunity. We investigated the effects of vitamins (vitamin A (VA), D (VD), E (VE)) and bioactives (i.e., resveratrol (Res), epigallocatechin-3-gallate (EGCG)) on the adaptive immune response, as well as their synergistic or antagonistic interactions. Freshly isolated T lymphocytes from healthy individuals were activated with anti-CD3/CD28 antibodies for 4–5 days in the presence of bioactives and were analyzed by cytofluorometry....
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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