The predictive value of left ventricular and left atrial mechanics for atrial fibrillation and heart failure in hypertrophic cardiomyopathy: a prospective cohort study

AbstractAtrial fibrillation (AF) and heart failure (HF) represent clinical turning points, altering the natural history of HCM and influencing long-term outcome of the disease. The aim of this study was to evaluate the ability of left ventricular (LV) and left atrial (LA) myocardial deformation parameters to predict new-onset AF and HF outcomes in patients with HCM. This was a prospective study that included HCM patients without severe valvular heart disease, prior myocardial infarction or history of AF. The study sample consisted of 250 patients (mean age 50.8  ± 15.8, 67.2% male). Two-dimensional (2D) speckle tracking deformation parameters including global longitudinal strain (GLS), radial strain, circumferential strain, LA reservoir strain (LAεres), LA conduit strain (LA εcon) and LA booster strain(LA εboost) were examined. During a mean follow-up of 2.5  ± 1.2 years, 44 patients developed new-onset AF. All the LV and LA deformation parameters were significant univariate predictors of AF. GLS and LAεres had the highest C statistic among the LV and LA functional indices. In multivariable analysis, only LA εres remained an independent predictor of the arrhythmia (HR 0.91, 95% CI 0.85 –0.98, p: 0.008). Similarly, GLS and LAεres had the highest predictive value among the 2D speckle tracking parameters for HF outcomes. LA εres remained an independent predictor after adj...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research

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lzania Marialuisa Zedde Patent Foramen Ovale (PFO) is a common postnatal defect of cardiac atrial septation. A certain degree of familial aggregation has been reported. Animal studies suggest the involvement of the Notch pathway and other cardiac transcription factors (GATA4, TBX20, NKX2-5) in Foramen Ovale closure. This review evaluates the contribution of genetic alterations in PFO development. We systematically reviewed studies that assessed rare and common variants in subjects with PFO. The protocol was registered with PROSPERO and followed MOOSE guidelines. We systematically searched English studies reporting ra...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
This study enrolled 60 patients randomly assigned into two groups.
Source: Seminars in Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ADULT – Original Submission Source Type: research
AN AUSTRALIAN study comparing medication and nutrition found that diet has the more profound impact on controlling diabetes, stroke and heart disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Egypt Heart J. 2021 Dec 4;73(1):104. doi: 10.1186/s43044-021-00230-0.ABSTRACTBACKGROUND: This meta-analysis aimed to assess the value of the C2HEST score to facilitate population screening and detection of AF risk in millions of populations and validate risk scores and their composition and discriminatory power for identifying people at high or low risk of AF. We searched major indexing databases, including Pubmed/Medline, ISI web of science, Scopus, Embase, and Cochrane central, using ("C2HEST" OR "risk scoring system" OR "risk score") AND ("atrial fibrillation (AF)" OR "atrial...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Indian Heart J. 2021 Nov-Dec;73(6):737-739. doi: 10.1016/j.ihj.2021.09.004. Epub 2021 Sep 14.ABSTRACTThis observational study investigates the prognostic significance of troponin I in patients undergoing primary percutaneous intervention (pPCI). Sequential cardiac biomarker sampling of the enrolled patients (n = 167) was performed on admission and at 6,12,24 and 48 h. Clinical characteristics, major adverse cardiac and cerebrovascular events (MACCE) (death, reinfarction, stroke and new or worsening heart failure) and left ventricular ejection fraction (LVEF) were noted on admission and 30 day follow-up. A 24-h troponin I l...
Source: Indian Heart J - Category: Cardiology Authors: Source Type: research
Indian Heart J. 2021 Nov-Dec;73(6):733-736. doi: 10.1016/j.ihj.2021.09.006. Epub 2021 Sep 10.ABSTRACTIn-stent restenosis and stent thrombosis are the major concerns while choosing a coronary stent. This single-centre, retrospective study evaluated the one and three-year clinical outcomes following implantation of Yukon Choice Flex (YCF) sirolimus-eluting stent. A total of 168 consecutive patients with 217 lesions underwent stenting with YCF stent. The presentation was with acute coronary syndrome in 158 (94%) patients. At 3 years, 9 (5.3%) patients died due to cardiac cause. Myocardial infarction, and definite stent thromb...
Source: Indian Heart J - Category: Cardiology Authors: Source Type: research
CONCLUSION: IDU is now the most important predisposition for IE in India, and S. aureus has become the leading cause of native valve endocarditis with or without IDU.PMID:34861981 | DOI:10.1016/j.ihj.2021.09.008
Source: Indian Heart J - Category: Cardiology Authors: Source Type: research
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Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Background The extent to which cognitive function differs between patients who receive implantable cardioverter-defibrillator (ICD) therapy and patients with heart failure (HF) who do not receive ICD therapy remains to be elucidated. Objectives The aim of this study was to compare the cognitive function between patients with primary or secondary ICDs and patients with HF without an ICD. Methods This descriptive, comparative study included 116 patients who received ICDs and 74 patients with HF who did not receive ICDs. Patients underwent neuropsychological assessment for general cognition, memory, and exec...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Background Cognitive impairment is prevalent in heart failure and is associated with higher mortality rates. The mechanism behind cognitive impairment in heart failure with preserved ejection fraction (HFpEF) has not been established. Objective The aim of this study was to evaluate associations between abnormal cardiac hemodynamics and cognitive impairment in individuals with HFpEF. Methods A secondary analysis of Atherosclerosis Risk in Communities (Atherosclerosis Risk in Communities) study data was performed. Participants free of stroke or dementia who completed in-person assessments at visit 5 were in...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
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