Regenerative potential of stem cells derived from human exfoliated deciduous (SHED) teeth during engineering of human body tissues.

Regenerative potential of stem cells derived from human exfoliated deciduous (SHED) teeth during engineering of human body tissues. Curr Stem Cell Res Ther. 2020 Dec 31;: Authors: Fuloria S, Jain A, Singh S, Hazarika I, Salile S, Fuloria NK Abstract Current decade witnesses the regenerative potential of stem cells (SCs) based life-saving therapies for the treatment of various disease and conditions. Human teeth act as reservoir for SCs that exist with high abundance in baby, wisdom, and permanent teeth. The collection of stem cells from human exfoliated deciduous teeth (SHED) is considered as a simple process as it offers the convenience of little or no pain. In comparison to the SCs from dental or bone marrow or other tissues, the SHED offers the benefit of higher cellular differentiation and proliferation. Massive in vitro and in vivo studies reveal the regenerative potential of SHED in the engineering of dental pulp tissue, neuronal tissue, root, bio root, cardiovascular tissues, lymphatic tissues, renal tissues, dermal tissues, hepatic tissues, and bone tissues. Current review describes the methods of collection/isolation/storage, various biomarkers, and types of SHED. This review highlights the regenerative potential of SHED in the engineering of different tissues of human body. As per the available research evidences present study supports that SHED may differentiate into the endothelial cells, neurons, odontoblasts, pancreatic...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research