Apolipoprotein A5 controls fructose-induced metabolic dysregulation in mice

Western dietary habits are partially characterized by increased uptake of fructose, which contributes to metabolic dysregulation and associated liver diseases. For example, a diet enriched with fructose drives insulin resistance and non-alcoholic fatty liver disease (NAFLD). The molecular hubs that control fructose-induced metabolic dysregulation are poorly understood. Apolipoprotein A5 (apoA5) controls triglyceride metabolism with a putative role in hepatic lipid deposition. We explored apoA5 as a rheostat for fructose-induced hepatic and metabolic disease in mammals.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 16, 2020 Category: Nutrition Authors: Claudia Ress, Jochen Dobner, Kerstin Rufinatscha, Bart Staels, Maximilian Hofer, Sabrina Folie, Bernhard Radlinger, Timon E. Adolph, Eduard M. Rubin, Michael Roden, Herbert Tilg, Susanne Kaser Source Type: research