Saturated Fatty Acids Promote Hepatocytic Senecence through Negative Regulation of miR ‐34a/Cyclin‐dependent Kinase 6

ConclusionOur findings revealed that miR ‐34a was upregulated in a high‐fat environment in the liver, and induced hepatocyte senescence by targeting CDK6. The miR‐34a‐CDK6 signaling axis may promote NAFLD development in a high‐fat environment and therefore represents a potential target for NAFLD therapy.This article is protected by copyright. All rights reserved

Source: Molecular Nutrition and Food Research - September 23, 2020 Category: Food Science Authors: Yu ‐e Qin, Li Duan, Yumin He, Chengfu Yuan, Ting Wang, Ding Yuan, Changcheng Zhang, Chaoqi Liu Tags: Research Article Source Type: research