Targetting S100b Protein as a Surrogate Biomarker and Its Role in Various Neurological Disorders.

Targetting S100b Protein as a Surrogate Biomarker and Its Role in Various Neurological Disorders. Curr Neuropharmacol. 2020 Jul 28;: Authors: Langeh U, Singh S Abstract Neurological disorders (ND) are the central nervous system (CNS) related complications originated by enhanced oxidative stress, mitochondrial failure and overexpression of proteins like S100B. S100B is a helix-loop-helix protein with calcium-binding domain associated to various neurological disorders through activation of MAPK pathway, increased NFkB expression results in cell survival, proliferation and gene up-regulation. S100B protein plays a crucial role in Alzheimer's disease, Parkinson's disease, multiple sclerosis, Schizophrenia and epilepsy because high expression of this protein directly targets astrocytes and promote neuroinflammation. Under stressful conditions, S100B produces toxic effect mediated through receptor for advanced glycation end products (AGE) binding. S100B also mediate neuroprotection, minimize microgliosis and reduce the expression of tumor necrosis factor (TNF-alpha) but that are concentration-dependent mechanisms. Increased level of S100B useful for assessing release of inflammatory markers, nitric oxide and excitotoxicity dependent neuronal loss. The present review summarizes the role of S100B in various neurological disorders and potential therapeutic measure to reduce the prevalence of neurological disorders. PMID: 32727332 [Pub...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research