In vivo characterization of metabotropic glutamate 2 and 5 receptors in Alzheimers Disease

Conclusions: Although mGluR2 and mGluR5 have different synaptic location and functional mechanism both [11C]mG2P001 and [18F]FPEB showed significantly decreased radioactivity in their specific receptor binding regions in AD mice model compared to that of the control group. The MWM behavior test further indicated the reduced hippocampal radioactivity attributed to the observed cognitive/memory impairment among AD mice, where 19.3% and 34.3% radioactivity decrease were seen for [11C]mG2P001 and [18F]FPEB in hippocampus, respectively. In addition, the aberrant changes of [11C]mG2P001 in subiculum, where the first accumulation of amyloid beta plaques was observed, in this AD model might bear a therapeutic potential. Our studies provide an in vivo evidence that alteration in the mGluR 2 & 5 occupying brain regions might contribute to AD pathology. Acknowledgements: The research was supported by NIH grants R01EB021708 and R01NS100164.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science - Inflammation and Dementia Source Type: research