Farnesol attenuates oxidative stress and liver injury and modulates fatty acid synthase and acetyl-CoA carboxylase in high cholesterol-fed rats.

In conclusion, FAR possesses a strong anti-hyperlipidemic/anti-hypercholesterolemic activity mediated through its ability to modulate hepatic FAS, ACC, and SREPB-1c. FAR prevented oxidative stress, inflammation, and liver injury induced by HCD. Thus, FAR may represent a promising lipid-lowering agent that can protect against dyslipidemia and its linked metabolic deregulations.
PMID: 32449150 [PubMed - as supplied by publisher]

Source: Environmental Science and Pollution Research International - May 23, 2020 Category: Environmental Health Authors: Abukhalil MH, Hussein OE, Bin-Jumah M, Saghir SAM, Germoush MO, Elgebaly HA, Mosa NM, Hamad I, Qarmush MM, Hassanein EM, Kamel EM, Hernandez-Bautista R, Mahmoud AM Tags: Environ Sci Pollut Res Int Source Type: research