Cancers, Vol. 12, Pages 936: Circulating miR-21 as a Potential Biomarker for the Diagnosis of Oral Cancer: A Systematic Review with Meta-Analysis
Cancers, Vol. 12, Pages 936: Circulating miR-21 as a Potential Biomarker for the Diagnosis of Oral Cancer: A Systematic Review with Meta-Analysis
Cancers doi: 10.3390/cancers12040936
Authors:
Mario Dioguardi
Giorgia Apollonia Caloro
Luigi Laino
Mario Alovisi
Diego Sovereto
Vito Crincoli
Riccardo Aiuto
Erminia Coccia
Giuseppe Troiano
Lorenzo Lo Muzio
Head and neck squamous cell carcinoma (HNSCC) is one of the main neoformations of the head–neck region and is characterized by the presence of squamous carcinomatous cells of the multi-layered epithelium lining the oral cavity, larynx, and pharynx. The annual incidence of squamous cell carcinoma of the head and neck (HNSCC) comprises approximately 600,000 new cases globally. Currently, the 5-year survival from HNSCC is less than 50%. Surgical, radiotherapy, and chemotherapy treatments strongly compromise patient quality of life. MicroRNAs (miRNAs) are a family of small noncoding endogenous RNAs that function in regulating gene expression by regulating several biological processes, including carcinogenesis. The main upregulated microRNAs associated with oral carcinoma are miR-21, miR-455-5p, miR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181, while the main downregulated miRNAs are miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b. miR-21 represents one of the first oncomirs studied. The present systematic review work was performed based on the preferred repo...
Source: Cancers - Category: Cancer & Oncology Authors: Mario Dioguardi Giorgia Apollonia Caloro Luigi Laino Mario Alovisi Diego Sovereto Vito Crincoli Riccardo Aiuto Erminia Coccia Giuseppe Troiano Lorenzo Lo Muzio Tags: Review Source Type: research
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