2-Methoxy-6-acetyl-7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1).

In conclusion, MAM induced GBM cell death by triggering an O2-2-/Ca2+/JNK1/2 dependent programmed necrosis. NQO1 might be the potential target for MAM and mediated its anticancer effect. This non-apoptotic necrosis might have therapeutic potentials for GBM treatment.
PMID: 32234332 [PubMed - as supplied by publisher]

Source: Free Radical Biology and Medicine - March 27, 2020 Category: Biology Authors: Yu J, Zhong B, Jin L, Hou Y, Ai N, Ge W, Li L, Liu S, Lu JJ, Chen X Tags: Free Radic Biol Med Source Type: research