Impact of DPP4 Inhibitors in Survival of Patients With Prostate, Pancreas, and Breast Cancer
Background: Dipeptidyl peptidase-4 (DPP4), a cell surface protein, exhibits a crucial role in tumor biology and regulation of the immune system. We aim to study the impact of DPP4 inhibitors (DPP4i) in patients with prostate cancer (PRC), pancreatic cancer (PC) and breast cancer (BC).Methods: Using the SEER and Medicare linked database, we identified patients with PRC or PC or BC with coexisting type II diabetes mellitus between 2007 and 2015. Patients were classified into four groups: (1) not on either DPP4i or metformin (reference group), this group included patient that were on anti-diabetic agents other than metformin or DPP4i (2) metformin only, (3) DPP4i only, and (4) DPP4i along with metformin (combination group). Overall survival (OS) analyses were performed using SAS®, version 9.4.Results: We identified 15,330 patients with PRC, 5,359 patients with PC and 16,085 patients with BC. In PRC cohort, patients on DPP4i had significant survival advantage with HR 0.77 (95% CI: 0.64–0.93), P = 0.005 when compared to the reference group. Patients taking metformin also had significant OS benefit with HR 0.87 (95% CI: 0.81–0.93), P
Publication date: Available online 30 May 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Renjie Wang, Zhengwei Cao, Lan Wei, Lin Bai, Hui Wang, Shiyi Zhou, Shuyue Zhan, Bin Ji, Zibo Li, Shi Gao, Jin Xie, Qingjie Ma
(American Association for Cancer Research) Among patients with both colorectal cancer and diabetes in Korea, those who had a high adherence to their oral diabetes medication had a significantly reduced risk of overall mortality compared with those with lower adherence.
Publication date: Available online 30 May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Deborah Delbue, Bruna S. Mendonça, Marcela C. Robaina, Lauana G.T. Lemos, Pedro I. Lucena, João P.B. Viola, Lídia M. Magalhães, Susanne Crocamo, Caio A.B. Oliveira, Felipe R. Teixeira, Raquel C. Maia, Gabriela Nestal de Moraes
Publication date: Available online 31 May 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Camila A.P. Monteiro, Aline D.P.R. Oliveira, Ryan C. Silva, Rennan R.M. Lima, Fabricio O. Souto, Mariana O. Baratti, Hernandes F. Carvalho, Beate S. Santos, Paulo E. Cabral Filho, Adriana Fontes
Publication date: Available online 30 May 2020Source: European UrologyAuthor(s): Heidi Fettke, Edmond M. Kwan, Maria M. Docanto, Patricia Bukczynska, Nicole Ng, Lisa-Jane K. Graham, Kate Mahon, Christine Hauser, Winston Tan, Xiao Hong Wang, Zhixin Zhao, Tiantian Zheng, Kemin Zhou, Pan Du, Jianjun Yu, Yong Huang, Shidong Jia, Manish Kohli, Lisa G. Horvath, Arun A. Azad
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Afsana Elanko, Jim Khan, Zaed ZR. Hamady, Hassan Malik
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Aoife Sartini-Bhreathnach, Edward Murphy, Siun Walsh, Malcolm Kell, Mitchell Barry, Claire Smith, Maurice Stokes
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Rebecca L. Wilson, George Boundouki, Julia R. Henderson, Paula Duxbury, James R. Harvey, Julie Wray, Rajiv Dave, Cliona C. Kirwan
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Pooja Padmanabhan, Syeda Nadia Shah Gilani, Polly Partlett, Elizabeth Clayton, Tracey Irvine, Farrokh Pakzad, Jonathan Horsnell
Author Affiliations open 1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada 2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain 4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain 5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada 6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA 7 Department of Economics, Brigham Young University, Provo, Utah, USA 8 Population Studies Division, Health Canada, Ottawa, Cana...