The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload.
The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload. Cardiol Res Pract. 2020;2020:4150291 Authors: Wang X, Pei J, Hu X Abstract Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of acute heart failure syndrome triggered by intense psychological or physiological stress. TTS typically manifests as acute chest pain, dyspnea or syncope that mimics an acute myocardial infarction but does not involve coronary artery obstruction. The current understanding of the pathogenesis of TTS suggests that sympathetic nervous system (SNS) activation plays a central role. Specifically, stress can activate the SNS and lead to the over-release of catecholamine, which have toxic effects on myocardial tissue when present at excessive levels. However, the brain changes associated with TTS and the connection between the brain and the heart in patients with this disease remain unclear. In recent years, several published reports have revealed the role of this brain-heart connection in the pathogenesis of TTS. This review summarizes recent studies regarding SNS activation, catecholamine overload, and the brain-heart connection in patients with TTS from both pathophysiological and mechanistic aspects. PMID: 32211202 [PubMed]
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Publication date: August 2020Source: IJC Heart &Vasculature, Volume 29Author(s): Inder Anand, Jeffrey L. Ardell, Doug Gregory, Imad Libbus, Lorenzo DiCarlo, Rajendra K. Premchand, Kamal Sharma, Sanjay Mittal, Rufino Monteiro
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Authors: Tzikas S, Papadopoulos C, Evangeliou AP, Vassilikos V PMID: 32470561 [PubMed - as supplied by publisher]
Authors: Versaci F, Scappaticci M, Calcagno S, Del Prete A, Romeo F, Peruzzi M, Cavarretta E, Frati G PMID: 32472994 [PubMed - as supplied by publisher]
CONCLUSIONS: Further studies are required in order to establish the complicated association between SARS-CoV-2 infection and its effects on the cardiovascular system. Our knowledge regarding diagnostic approaches, therapeutic management and preventive measures is constantly enriched throughout an abundance of ongoing research in the respective fields. PMID: 32472990 [PubMed - as supplied by publisher]
Authors: Nudi F, Nudi A, Neri G, Procaccini E, Schillaci O, Versaci F, Frati G, Biondi-Zoccai G Abstract BACKGROUND: The management of patients with unprotected left main (LM) coronary artery disease remains challenging, with recent data casting a shadow of doubt on the safety of percutaneous coronary intervention. We aimed at describing the features of patients undergoing myocardial perfusion imaging subsequently found to have LM disease. METHODS: We queried our institutional database for subjects without prior revascularization or myocardial infarction (MI), who had undergone MPI followed by invasive coronary...