Mirogabalin besylate in the treatment of neuropathic pain.
Mirogabalin besylate in the treatment of neuropathic pain. Drugs Today (Barc). 2020 Feb;56(2):135-149 Authors: Burgess J, Javed S, Frank B, Malik RA, Alam U Abstract Neuropathic pain (NeP) is a global cause of suffering and debilitation leading to significant morbidity and reduced quality of life. New treatments are needed to address the growing prevalence of NeP and its impact on sleep, mood and functionality. Mirogabalin besylate (mirogabalin, Tarlige) is a gabapentinoid therapy developed by Daiichi Sankyo which is approved in Japan for the treatment of postherpetic neuralgia and painful diabetic peripheral neuropathy. Mirogabalin has a potent pain-modulating effect with a unique high affinity and prolonged dissociation rate for the a2delta-1 subunit of voltage-gated calcium (Ca2+) channels (VGCCs) on the dorsal root ganglion resulting in more sustained analgesia compared with traditional gabapentinoids. Additionally, mirogabalin has a superior adverse events (AEs) profile due to a rapid dissociation from the a2delta-2 subunit of VGCCs potentially implicated in central nervous system-specific AEs. The most common AEs for mirogabalin are dizziness (approximately 8-16%), somnolence (approximately 6-24%) and headache (approximately 6-14%), with a lower incidence of constipation, nausea, diarrhea, vomiting, edema, fatigue and weight gain. Postmarketing studies are required to evaluate its analgesic durability and efficacy when combined with other antineurop...
The index, which considers several sleep disturbances, is superior to looking at isolated sleep issues in predicting subsequent cardio- and cerebrovascular events.Medscape Medical News
CONCLUSION: The results suggest the limited relevance of the "retired husband syndrome" among middle-aged Japanese couples. The effects of a husband's retirement on the wife's mental health depended heavily on her prior behavior. PMID: 32448823 [PubMed - as supplied by publisher]
CONCLUSIONS: Most studies found GDM screening to be cost-effective, though uncertainties remain due to many factors. The quality assessment identified weaknesses in the economic evaluations in terms of integrating existing data, measuring costs and consequences, analyzing perspectives, and adjusting for uncertainties. PMID: 32448822 [PubMed - as supplied by publisher]
PMID: 32449288 [PubMed - in process]
PMID: 32449287 [PubMed - in process]
Publication date: Available online 25 May 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ana M. Micov, Maja A. Tomić, Marija B. Todorović, Milja J. Vuković, Uroš B. Pecikoza, Nebojsa I. Jasnic, Jelena D. Djordjevic, Radica M. Stepanović-Petrović
Acase report inSchizophrenia Bulletin suggests that patients who are taking clozapine may be at risk of clozapine toxicity if they become infected with COVID-19. Clozapine is considered the best option for patients with treatment-resistant schizophrenia, but patients taking the medication are at heightened risk of a rare but serious condition known as neutropenia, which can increase risk of severe infections.In theSchizophrenia Bulletinreport, Thomas Cranshaw, M.B.B.S., and Thiyyancheri Harikumar, M.B.B.S., of Cumbria, Northumberland, Tyne, and Wear NHS Foundation Trust in England, described a 38-year-old man in an inpatie...
CONCLUSION: The anti-inflammatory property is suggested the mechanism action of PG for protection human lymphocytes against genotoxicity induced by ionizing radiation. PMID: 32448107 [PubMed - as supplied by publisher]
This study aimed at testing the effect of vitamin D supplements on urinary megalin levels in diabetic nephropathy (DN) patients with vitamin D hypovitaminosis. METHODS: A sample of 63 participants with vitamin D deficiency with diabetic nephropathy (DN) were enrolled in the pre-post study; urinary megalin levels with various clinical parameters and serum levels of vitamin D3 were measured and compared to the baseline at 3- and 6-month intervals. RESULTS: Interestingly, a supplementation related increase in serum vitamin D3 levels at 3- and 6- month interventions affected a constellation of ameliorations in the DN p...
This article is part of the theme issue 'Uncertainty quantification in cardiac and cardiovascular modelling and simulation'. PMID: 32448059 [PubMed - in process]