Dietary polyunsaturated fat intake in relation to head and neck, esophageal, and gastric cancer incidence in the NIH-AARP Diet and Health Study.

Dietary polyunsaturated fat intake in relation to head and neck, esophageal, and gastric cancer incidence in the NIH-AARP Diet and Health Study. Am J Epidemiol. 2020 Mar 06;: Authors: Zamani SA, McClain KM, Graubard BI, Liao LM, Abnet CC, Cook MB, Petrick JL Abstract n-3 polyunsaturated fatty acids (PUFAs) express anti-inflammatory properties and prevent tumor progression. Conversely, n-6 PUFAs exhibit carcinogenic properties. Recent epidemiologic studies have examined the association of fish with upper gastrointestinal cancer risk, but the associations with n-3 and n-6 PUFA subtypes remain unclear. Utilizing the NIH-AARP Diet and Health Study (1995-2011), we prospectively investigated the associations of PUFA subtypes, ratios, and fish with the incidence of head and neck (HNC, n=2,453), esophageal (n=855 adenocarcinoma, EA, and n=267 squamous cell carcinoma, ESCC), and gastric (n=603 cardia, GCA, and n=631 non-cardia, NCGA) cancers among 468,952 participants (median follow-up 15.5 years). A food frequency questionnaire assessed diet. Multivariable-adjusted HRs and 95% CIs were estimated using Cox proportional hazards regression. A Benjamini-Hochberg (BH) procedure was used for false-discovery control. Long-chain n-3 PUFAs were associated with a 20% decreased HNC and EA risk (quintile5vs.1 HR=0.81, 95% CI: 0.71-0.92, BH-adjusted P-trend=0.001 and HR=0.79, 95% CI: 0.64-0.98, BH-adjusted P-trend=0.1, respectively). Similar associations...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research