Molecules, Vol. 25, Pages 1171: In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

Molecules, Vol. 25, Pages 1171: In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain Molecules doi: 10.3390/molecules25051171 Authors: Paramita Basu Arpita Basu Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including spared nerve injury, spinal nerve ligation, partial sciatic nerve injury, diabetes-induced neuropathy, chemotherapy-induced neuropathy, chronic constriction injury, and related conditions. The drugs which are currently used to attenuate peripheral neuropathy, such as antidepressants, anticonvulsants, baclofen, and clonidine, are associated with adverse side effects. These negative side effects necessitate the investigation of alternative therapeutics for treating neuropathic pain conditions. Flavonoids have been reported to alleviate neuropathic pain in murine models. The present review elucidates that several flavonoids attenuate different peripheral neuropathic pain conditions at behavioral, electrophysiological, biochemical and molecular biological levels in different murine models. Therefore, the flavonoids hold future promise and can be effectively used in treating or mitigating peripheral neuropathic conditions. Thus, future studies should focus on t...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research