Notes from the field: xylazine, a veterinary tranquilizer, identified as an emerging novel substance in drug overdose deaths -- Connecticut, 2019-2020 - Thangada S, Clinton HA, Ali S, Nunez J, Gill JR, Lawler RF, Logan SB.
Xylazine, a clonidine analog, is a nonopioid veterinary tranquilizer not intended for human use. Recreational drugs such as cocaine, heroin, and fentanyl are often adulterated with agents such as xylazine to enhance drug effects or increase street value by... (Source: SafetyLit)
Source: SafetyLit - September 18, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

What Causes Anisocoria?
Discussion Anisocoria is a common physical finding caused by the mechanical imbalance of the iris dilator (sympathetic innervation causing dilation) and sphincter muscles (parasympathetic innervation causes miosis). Which pupil is abnormal is important to determine. “Anisocoria greater in the light signifies an abnormal large pupil, whereas anisocoria in the dark indicates an abnormal small pupil.” The pupillary size should be noted along with any changes with accommodation, extra ocular movements and lighting. The time it takes to revert to the baseline pupillary size can also be helpful. Any ptosis, lacrimati...
Source: PediatricEducation.org - August 23, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Class 3 Medicines Recall: SyriMed, Clonidine hydrochloride 50micrograms/5ml Oral Solution
SyriMed are recalling the batches of Clonidine hydrochloride 50micrograms/5ml Oral Solution as a precautionary measure due to an issue related to the container closure (child-lock cap). Further detai (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - February 17, 2021 Category: Drugs & Pharmacology Source Type: news

"Road rash" and dizziness: a case of hemodynamically significant topical clonidine toxicity - Downs JW, Cumpston KL.
We report a case of uninten... (Source: SafetyLit)
Source: SafetyLit - October 5, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

What Causes Bradycardia?
Discussion Bradycardia is a heart rate below what the lowest value that is normal for age. Infants and children have higher heart rates that slowly decrease with age to adult levels. It is usually noted as an incidental finding because of increased vagal tone. Reasons for cardiology referral include associated heart murmur, syncope especially if associated with exercise or unusual triggers, other signs such as chest pain or palpitations, family history of sudden cardiac death, congenital heart disease or familial heart disease, bradycardic medication use, or unusual symptoms associated with the concern. Severe bradycardia ...
Source: PediatricEducation.org - June 22, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Fresenius Kabi's Recall of Ketorolac Results In QuVa Pharma ® Recall of Compounded Sterile Product (R.E.C.K.)
QuVa Pharma, Inc. confirms that is working with the U.S. Food and Drug Administration, and voluntarily recalling all lots of R.E.C.K. (Ropivacaine, Epinephrine, Clonidine, Ketorolac) 50 ml in Sodium Chloride-60 ml BD syringe that were prepared using sterile Ketorolac being recalled by Fresenius Kabi (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - April 27, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

What Are Some Risk Factors for Cerebral Palsy?
Discussion The term, cerebral palsy, or CP has gone through many iterations with the first description in 1861 by W.J. Little who described it as “The condition of spastic rigidity of the limbs of newborn children.” The most recent definition is from Rosenbaun et al. in 2007 which states it is “a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cog...
Source: PediatricEducation.org - March 9, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Medicine Supply Notifications - Clonidine and H2-antagonists (cimetidine, famotidine and nizatidine)
The Department of Health and Social Care (DHSC) has issued the following Medicine Supply Notifications: (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - December 23, 2019 Category: Drugs & Pharmacology Source Type: news