Notes from the field: xylazine, a veterinary tranquilizer, identified as an emerging novel substance in drug overdose deaths -- Connecticut, 2019-2020 - Thangada S, Clinton HA, Ali S, Nunez J, Gill JR, Lawler RF, Logan SB.
Xylazine, a clonidine analog, is a nonopioid veterinary tranquilizer not intended for human use. Recreational drugs such as cocaine, heroin, and fentanyl are often adulterated with agents such as xylazine to enhance drug effects or increase street value by... (Source: SafetyLit)
Source: SafetyLit - September 18, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

What Causes Anisocoria?
Discussion Anisocoria is a common physical finding caused by the mechanical imbalance of the iris dilator (sympathetic innervation causing dilation) and sphincter muscles (parasympathetic innervation causes miosis). Which pupil is abnormal is important to determine. “Anisocoria greater in the light signifies an abnormal large pupil, whereas anisocoria in the dark indicates an abnormal small pupil.” The pupillary size should be noted along with any changes with accommodation, extra ocular movements and lighting. The time it takes to revert to the baseline pupillary size can also be helpful. Any ptosis, lacrimati...
Source: PediatricEducation.org - August 23, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Class 3 Medicines Recall: SyriMed, Clonidine hydrochloride 50micrograms/5ml Oral Solution
SyriMed are recalling the batches of Clonidine hydrochloride 50micrograms/5ml Oral Solution as a precautionary measure due to an issue related to the container closure (child-lock cap). Further detai (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - February 17, 2021 Category: Drugs & Pharmacology Source Type: news

"Road rash" and dizziness: a case of hemodynamically significant topical clonidine toxicity - Downs JW, Cumpston KL.
We report a case of uninten... (Source: SafetyLit)
Source: SafetyLit - October 5, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

What Causes Bradycardia?
Discussion Bradycardia is a heart rate below what the lowest value that is normal for age. Infants and children have higher heart rates that slowly decrease with age to adult levels. It is usually noted as an incidental finding because of increased vagal tone. Reasons for cardiology referral include associated heart murmur, syncope especially if associated with exercise or unusual triggers, other signs such as chest pain or palpitations, family history of sudden cardiac death, congenital heart disease or familial heart disease, bradycardic medication use, or unusual symptoms associated with the concern. Severe bradycardia ...
Source: PediatricEducation.org - June 22, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Fresenius Kabi's Recall of Ketorolac Results In QuVa Pharma ® Recall of Compounded Sterile Product (R.E.C.K.)
QuVa Pharma, Inc. confirms that is working with the U.S. Food and Drug Administration, and voluntarily recalling all lots of R.E.C.K. (Ropivacaine, Epinephrine, Clonidine, Ketorolac) 50 ml in Sodium Chloride-60 ml BD syringe that were prepared using sterile Ketorolac being recalled by Fresenius Kabi (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - April 27, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

What Are Some Risk Factors for Cerebral Palsy?
Discussion The term, cerebral palsy, or CP has gone through many iterations with the first description in 1861 by W.J. Little who described it as “The condition of spastic rigidity of the limbs of newborn children.” The most recent definition is from Rosenbaun et al. in 2007 which states it is “a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cog...
Source: PediatricEducation.org - March 9, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Medicine Supply Notifications - Clonidine and H2-antagonists (cimetidine, famotidine and nizatidine)
The Department of Health and Social Care (DHSC) has issued the following Medicine Supply Notifications: (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - December 23, 2019 Category: Drugs & Pharmacology Source Type: news

hydralazine (Apresoline) vs. clonidine (Catapres, Kapvay)
Title: hydralazine (Apresoline) vs. clonidine (Catapres, Kapvay)Category: MedicationsCreated: 11/8/2019 12:00:00 AMLast Editorial Review: 11/8/2019 12:00:00 AM (Source: MedicineNet High Blood Pressure General)
Source: MedicineNet High Blood Pressure General - November 8, 2019 Category: Cardiology Source Type: news

Google Honors Pioneering Psychiatrist Herb Kleber, Who Treated Addiction as a Disease, Not a Moral Failing
Dr. Herbert Kleber, one of the first major researchers to treat addiction as a disease, not a moral failing, is remembered by Google Doodle on the 23rd anniversary of his election to the National Academy of Medicine. The Doodle, illustrated by Massachusetts-based artist and author Jarrett J. Krosoczka, celebrates Kleber, who throughout his 50-year career was recognized as a pioneer in the field of addiction research who revolutionized the way addiction is treated and viewed in the medical community. According to Google, through his work “Dr. Kleber changed the landscape of addiction treatment, allowing patients to be...
Source: TIME: Health - October 1, 2019 Category: Consumer Health News Authors: Gina Martinez Tags: Uncategorized Drugs Google onetime Source Type: news

Metoprolol vs. clonidine
Title: Metoprolol vs. clonidineCategory: MedicationsCreated: 5/9/2019 12:00:00 AMLast Editorial Review: 5/9/2019 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - May 9, 2019 Category: Drugs & Pharmacology Source Type: news

Clonidine Testing for Diagnosing Growth Hormone Deficiency Clonidine Testing for Diagnosing Growth Hormone Deficiency
Is the clonidine test a reliable diagnostic tool for suspected growth hormone deficiency?Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 7, 2019 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Clonidine exposures in children under 6 (2004-2017): a retrospective study - Cairns R, Brown JA, Buckley NA.
OBJECTIVE: To describe trends in clonidine exposures in children under 6. Clonidine has become increasingly popular for management of paediatric behavioural disorders. Clonidine has a narrow therapeutic index, and toxicity can occur with inadvertent double... (Source: SafetyLit)
Source: SafetyLit - November 16, 2018 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

FDA Warns Against Off-Label Use of Implantable Pain Pumps
FDA is cautioning doctors and patients about the serious complications that can occur when using medications not approved for use with implanted pumps that deliver medication into the spinal fluid to treat or manage pain. Complications may include dosing errors, pump failure, opioid withdrawal, and infection, not to mention pain,  muscle spasms, cognitive changes, weakness, and cardiac or respiratory distress. “The treatment of pain has become increasingly complex. While medical devices, such as implanted pumps that deliver medication directly into the spinal fluid, have the potent...
Source: MDDI - November 14, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Regulatory and Compliance Implants Source Type: news

Which Drugs Work Best for ADHD? Large Study Zeroes in on Two
The researchers compared seven ADHD drugs -- amphetamines (including lisdexamfetamine), atomoxetine, bupropion, clonidine, guanfacine, methylphenidate and modafinil -- and a placebo over 12 weeks of treatment. (Source: WebMD Health)
Source: WebMD Health - August 8, 2018 Category: Consumer Health News Source Type: news

Spironolactone Over Clonidine in Resistant HTN: Do You Agree? Spironolactone Over Clonidine in Resistant HTN: Do You Agree?
Dr Desai asks, would you consider spironolactone for treating patients with resistant hypertension?Medscape Nephrology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 2, 2018 Category: Consumer Health News Tags: Nephrology Viewpoint Source Type: news

Spironolactone Favored Over Clonidine for Resistant Hypertension Spironolactone Favored Over Clonidine for Resistant Hypertension
Spironolactone appears to be a better fourth drug than clonidine for treating patients with resistant hypertension, researchers from Brazil report.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 9, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Self-Inflicted Injuries Surge Among Tween & Early Teen Girls
By Susan Scutti, CNN (CNN) — Emergency room visits for non-fatal, self-inflicted injuries surged in recent years among US girls and young women, especially those between the ages of 10 and 14, according to a new study. However, rates of self-harm among boys and young men between the ages of 10 and 24 remained stable throughout the years 2001 through 2015, the researchers said. “Suicide is preventable,” said Melissa C. Mercado, lead author of the study published Tuesday in JAMA and a behavioral scientist at the US Centers for Disease Control and Prevention. “These findings underscore the need for the...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 21, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Suicide Source Type: news

Monopar receives licence to develop Onxeo ’s Validive oral mucositis treatment
Onxeo has granted a global exclusive licence to Monopar Therapeutics for its Validive (clonidine mucoadhesive buccal) tablet used to treat severe oral mucositis induced by radiotherapy or chemotherapy in patients suffering from head and neck cancer. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - September 13, 2017 Category: Pharmaceuticals Source Type: news

Kapvay (clonidine extended-release)
Title: Kapvay (clonidine extended-release)Category: MedicationsCreated: 11/13/2014 12:00:00 AMLast Editorial Review: 8/8/2017 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - August 8, 2017 Category: Pediatrics Source Type: news

Is Clonidine Safe for Children?
Title: Is Clonidine Safe for Children?Category: Doctor's& Expert's views on SymptomsCreated: 6/5/2017 12:00:00 AMLast Editorial Review: 6/5/2017 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - June 5, 2017 Category: Drugs & Pharmacology Source Type: news

Catapres-TTS (Clonidine) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 31, 2017 Category: Drugs & Pharmacology Source Type: news

Catapres (Clonidine) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 31, 2017 Category: Drugs & Pharmacology Source Type: news

clonidine (Catapres, Catapres-TTS)
Title: clonidine (Catapres, Catapres-TTS)Category: MedicationsCreated: 5/11/1998 12:00:00 AMLast Editorial Review: 1/30/2017 12:00:00 AM (Source: MedicineNet High Blood Pressure General)
Source: MedicineNet High Blood Pressure General - January 30, 2017 Category: Cardiology Source Type: news

Kapvay (Clonidine Hydrochloride Extended-Release Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 26, 2017 Category: Drugs & Pharmacology Source Type: news

BioDelivery ’ s topical gel for diabetic neuropathy fails in phase IIb trial
BioDelivery Sciences International (NSDQ:BDSI) said today that its clonidine topical gel for pain relief in patients with diabetic neuropathy failed in a phase IIb clinical trial. Raleigh, N.C.-based BioDelivery will halt any further development of the painkiller. In the phase IIb clinical trial, BioDelivery’s topical gel did not demonstrate a statistically significant difference in pain relief compared to a placebo. The company licensed the clonidine topical gel from Arcion Therapeutics to develop and commercialize it in March 2013. Get the full story at our sister site, Drug Delivery Business News. T...
Source: Mass Device - December 13, 2016 Category: Medical Equipment Authors: Sarah Faulkner Tags: Clinical Trials Diabetes Pain Management Pharmaceuticals BioDelivery Sciences International Source Type: news

Jenloga (Clonidine Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 9, 2016 Category: Drugs & Pharmacology Source Type: news

Duraclon (Clonidine Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - August 29, 2016 Category: Drugs & Pharmacology Source Type: news

FDA Warns Former Sun Pharma U.S. Drug Factory Over Quality Concerns FDA Warns Former Sun Pharma U.S. Drug Factory Over Quality Concerns
The U.S. Food and Drug Administration has pulled up a former Sun Pharmaceutical drug factory for"knowingly" releasing 27 lots of the hypertension drug clonidine last year, despite proof that the raw materials used may have been contaminated.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 26, 2016 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

FDA warns former Sun Pharma U.S. drug factory over quality concerns
MUMBAI (Reuters) - The U.S. Food and Drug Administration has pulled up a former Sun Pharmaceutical drug factory for "knowingly" releasing 27 lots of the hypertension drug clonidine last year, despite proof that the raw materials used may have been contaminated. (Source: Reuters: Health)
Source: Reuters: Health - August 26, 2016 Category: Consumer Health News Tags: healthNews Source Type: news

Clonidine as a Sedative Agent After Neonatal Cardiac SurgeryClonidine as a Sedative Agent After Neonatal Cardiac Surgery
For the sedation of infants after cardiac surgery, is clonidine a safe and effective choice? Pediatric Critical Care Medicine (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - June 27, 2016 Category: Surgery Tags: Critical Care Journal Article Source Type: news

clonidine, Catapres, Catapres-TTS
Title: clonidine, Catapres, Catapres-TTSCategory: MedicationsCreated: 5/11/1998 12:00:00 AMLast Editorial Review: 5/31/2016 12:00:00 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - May 31, 2016 Category: Endocrinology Source Type: news

Value of Adrenergic Blockade in Acute Severe TBI QuestionedValue of Adrenergic Blockade in Acute Severe TBI Questioned
Adrenergic blockade with propranolol and clonidine did not increase ventilator-free days after severe traumatic brain injury, a new study shows. Medscape Medical News (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - April 28, 2016 Category: Intensive Care Tags: Neurology & Neurosurgery News Source Type: news

Drug and behavioural therapy are both effective for tics in people with Tourette syndrome
There are effective drug and behavioural treatments for tics in children and young people with Tourette syndrome. Although most of the studies included in this review were small with risk of , the effects found were moderate to large and likely to be clinically meaningful. This NIHR funded and qualitative study found that habit reversal therapy, where people with Tourette's are taught to replace their tic with a less noticeable alternative, was effective. The drugs with the best balance of benefits and harms – risperidone, clonidine and aripiprazole – are those most commonly used in the UK. (Source: Current Awa...
Source: Current Awareness Service for Health (CASH) - April 7, 2016 Category: Consumer Health News Source Type: news

U.S. Jails Are Killing People Going Through Opioid Withdrawals
Conclusions **Gorski lists five symptoms of Post Incarceration Syndrome: 1) Institutionalized Personality Traits; 2) Post Traumatic Stress Disorder; 3) Antisocial Personality Traits; 4) Social-Sensory Deprivation Syndrome; and 5) Reactive Substance Use Disorders, and indicates symptoms are most severe in prisoners incarcerated for longer than a year, who have multiple episodes of incarceration, have little to no access to educational/vocational training, are subject to 30 days solitary confinement, or have experienced severe trauma as a result of institutional abuse--meaning an extremely large segment of the formerly incar...
Source: Healthy Living - The Huffington Post - March 29, 2016 Category: Consumer Health News Source Type: news

Shares of Raleigh's BioDelivery plummet 30 percent
Raleigh drug developer BioDelivery Sciences International (Nasdaq: BDSI) lost more than a quarter of its market value Monday after it announced disappointing trial results on an experimental pain treatment under development. Shares traded down more than 30 percent from Friday’s close at one point and hovered around the $10 mark Monday morning. Shares closed at nearly $14 on Friday and have been as high as $18.48 in the past year. BioDelivery had tested its Clonidine Topical Gel as a treatment… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - March 30, 2015 Category: American Health Authors: Jason deBruyn Source Type: news

Medication finds new use in sustaining opioid quit success
New research suggests that clonidine, a medication for high blood pressure and attention deficit hyperactivity disorder (ADHD), can enhance buprenorphine’s ability to treat opioid dependence. This combination of medications reduces stress-induced craving and prolongs opioid abstinence during... (Source: NIDA News)
Source: NIDA News - March 18, 2015 Category: Addiction Tags: Health and Medical Professionals, Opioids, Treatment Research Source Type: news

clonidine, Catapres, Catapres-TTS, Kapvay
Title: clonidine, Catapres, Catapres-TTS, KapvayCategory: MedicationsCreated: 5/11/1998 12:00:00 AMLast Editorial Review: 2/25/2015 12:00:00 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - February 25, 2015 Category: Endocrinology Source Type: news

Help at hand for women like Kate who must endure acute morning sickness in early pregnancy
Clonidine, a commonly used remedy for lowering blood pressure, is proving beneficial for women, such as the Duchess of Cambridge, who expereince hyperemesis gravidarum (Source: The Telegraph : Health Advice)
Source: The Telegraph : Health Advice - December 8, 2014 Category: Consumer Health News Tags: Kate Middleton morning sickness pregnancy Duchess of Cambridge Doctor's Diary James Le Fanu Source Type: news

Help at hand for women like Kate who must endure acute morning sickness in early pregnancy
Clonidine, a commonly used remedy for lowering blood pressure, is proving beneficial for women, such as the Duchess of Cambridge, who expereince hyperemesis gravidarum (Source: Telegraph Health)
Source: Telegraph Health - December 8, 2014 Category: Consumer Health News Tags: Kate Middleton morning sickness pregnancy Duchess of Cambridge Doctor's Diary James Le Fanu Source Type: news

Aspirin, Clonidine Fail to Halt Nephropathy After SurgeryAspirin, Clonidine Fail to Halt Nephropathy After Surgery
The perioperative use of aspirin or clonidine does not prevent kidney injury, a substudy of POISE-2 suggests, and can lead to major bleeding and hypotension. Medscape Medical News (Source: Medscape Nephrology Headlines)
Source: Medscape Nephrology Headlines - November 20, 2014 Category: Urology & Nephrology Tags: Nephrology News Source Type: news

Perioperative Aspirin, Clonidine Do Not Protect Against Acute Kidney Injury (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH Among patients undergoing noncardiac surgery, neither aspirin nor clonidine given perioperatively lowers the risk for acute … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 17, 2014 Category: Primary Care Source Type: news

Clonidine, Aspirin Fail to Lower AKI Risk During Surgery
(MedPage Today) -- Neither antiplatelet nor vasoactive treatment prevents acute kidney injury. (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - November 15, 2014 Category: Surgery Source Type: news

Aspirin or blood pressure medication before and after surgery does not reduce risk of AKI
(The JAMA Network Journals) In patients undergoing noncardiac surgery, neither aspirin nor clonidine (a medication primarily used to treat high blood pressure) taken before and after surgery reduced the risk of acute kidney injury, according to a study appearing in JAMA. The study is being released to coincide with its presentation at the American Society of Nephrology's annual Kidney Week meeting. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 15, 2014 Category: Global & Universal Source Type: news