Fatality of Staphylococcus aureus infections in a Greek university hospital: role of inappropriate empiric treatment, methicillin resistance, and toxin genes ’ presence

AbstractThe aim of the present study was to identify predictors of fatality among patients withS. aureus infections requiring hospitalization. Cases hospitalized withS. aureus infections at the University General Hospital of Patras, Greece, during a 4-year period (2013 –2016) were studied.mecA, lukS/lukF-PV (Panton-Valentine leukocidin, PVL),tst (toxic shock syndrome toxin),fnbA (fibronectin-binding protein A),eta, andetb (epidermolytic toxins) genes ’ carriage was detected by PCR in 149 selected patients. Among 464 patients, 346 were included (118 with missing data). Primary bacteremia predominated (44.2%), followed by lower respiratory tract infections (13.6%), deep seated infections (9.8%), osteoarticular (9.5%), and catheter-related bloods tream infections (6.1%). Methicillin-resistantS. aureus (MRSA) represented 33.8% of infections and were less likely to receive appropriate empiric treatment (79.5%versus 97.4%;P
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research

Related Links:

Conclusions. High levels of preexisting MDR bacteria in allografts did not increase early PTP and mortality rates in LTRs. Despite the small and highly selective study population, lung allografts with MDR bacteria may be safely transplanted with appropriate posttransplant antibiotic therapy.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
AbstractReal-world data on regimens for relapsed/refractory multiple myeloma (RRMM) represent an important component of therapeutic decision-making. This multi-centric, retrospective, observational study conducted by the treating physicians evaluated the effectiveness and safety of ixazomib-lenalidomide-dexamethasone (IRd) in 155 patients who received ixazomib via early access programs in Greece, the UK, and the Czech Republic. Median age was 68  years; 17% had an Eastern Cooperative Oncology Group performance status ≥ 2; median number of prior therapies was 1 (range 1–7); 91%, 47%, and 17% had receive...
Source: Annals of Hematology - Category: Hematology Source Type: research
Incidence of and risk factors for chronic lung allograft dysfunction (CLAD) in lung transplantation for cystic fibrosis (CF) are not established. Methicillin resistant staphylococcus aureus (MRSA) is associated with CF morbidity but its association with CLAD is unclear. We aimed to describe CLAD incidence and assess if pre-transplant MRSA colonization is associated with CLAD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (756) Source Type: research
ConclusionsThe recommendations provided in this document are intended to assist the clinician in optimizing vancomycin for the treatment of invasive MRSA infections in adult and pediatric patients. An AUC/MIC by broth microdilution (BMD) ratio of 400 to 600 (assuming MICBMD of 1 mg/L) should be advocated as the target to achieve clinical efficacy while improving patient safety for patients with serious MRSA infections. In such cases, AUC ‐guided dosing and monitoring is the most accurate and optimal way to manage vancomycin therapy.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Special Article Source Type: research
When Vanessa is asked to clean up after patients who have the seasonal flu or measles or MRSA in the Pennsylvania hospital where she works in environmental services, she knows what to do. She knows how to disinfect surfaces, what needs to be thrown away and what she should wear to protect herself. But when she’s asked to clean rooms occupied by COVID-19 patients, she’s flying blind. “It’s kind of terrifying,” says Vanessa, who TIME is identifying by first name only for professional protection. Her supervisors told her to clean the rooms just as she would for a flu patient, but she says she&rsq...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
By Emma Young “At least since the philosophers of ancient Greece, scholars have pointed out the analogy between madness (psychosis) and dreaming…” So begins a new paper, published in PLoS One, that seems to shore up that analogy. Dreams and psychotic hallucinations do have things in common. They both feature perceptual sensations that seem real, but which are conjured up by our brains. However, there are also differences. While dreams are known to be highly visual, psychotic hallucinations are primarily auditory. They generally involve hearing things that aren’t real rather than seeing things ...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Perception Psychosis Sleep and dreaming Source Type: blogs
ConclusionsThe recommendations provided in this document are intended to assist the clinician in optimizing vancomycin for the treatment of invasive MRSA infections in adult and pediatric patients. An AUC/MIC by broth microdilution (BMD) ratio of 400 to 600 (assuming MICBMD of 1 mg/L) should be advocated as the target to achieve clinical efficacy while improving patient safety for patients with serious MRSA infections. In such cases, AUC ‐guided dosing and monitoring is the most accurate and optimal way to manage vancomycin therapy.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Special Article Source Type: research
ConclusionsThus, hMCs exhibit a highly individualized pattern of immune response possibly to meet tissue requirements and regulate bacteria coexistence vs defense.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionsDental pulp with specific tissue is a suitable sample for detection of the blood infection in the past through DNA and protein identification with the correct preparation process, furthermore, it helps to more understand the pathogens of historic diseases and epidemics.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: REVIEW ARTICLE Source Type: research
Sepsis is defined as dysregulated host response caused by systemic infection, leading to organ failure. It is a life-threatening condition, often requiring admission to an intensive care unit (ICU). The causative agents and processes involved are multifactorial but are characterized by an overarching inflammatory response, sharing elements in common with severe inflammatory response syndrome (SIRS) of non-infectious origin. Sepsis presents with a range of pathophysiological and genetic features which make clinical differentiation from SIRS very challenging. This may reflect a poor understanding of the key gene inter-activi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
More News: Genetics | Greece Health | Hospitals | Infectious Diseases | Microbiology | MRSA | Respiratory Medicine | Septic Shock | Staphylococcus Aureus | Study | Superbugs | Toxic Shock Syndrome | Toxicology