Scientists Confirm That Stress Can Indeed Turn Hair Grey

When Ya-Chieh Hsu, professor of stem cell and regenerative biology at Harvard University and the Harvard Stem Cell Institute, wanted to figure out exactly what makes hair turn grey, she started with an obvious, albeit anecdotal, culprit: stress. There are well-known historical examples of the connection between stress and hair greying—Marie Antoinette’s coif reportedly blanched after she was captured during the French Revolution—and studies have even linked stress in animals to greying hair. But for the first time, Hsu and her colleagues figured out the biological reason why stress saps the pigment out of hair. In a study published in Nature, Hsu and her team report that the process starts with the sympathetic nervous system, which orchestrates all of the critical body processes that we never have to think about—our heart rate, our breathing, as well as things like digesting food and fighting off germs. It is also responsible for the fight-or-flight response—the auto-pilot behavior system that helps us to recognize and respond to threats before we really have time to think about and process them. The sympathetic nervous system is intimately linked to our stress response, so in that respect it’s not entirely surprising it might have something to do with greying hair. But the sympathetic nervous system’s response to stress is generally one of last resort, activated only in a dire emergency when other systems are too slow or have failed...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized grey hair Stress Source Type: news

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Am J Hypertens. 2021 Mar 11;34(2):125-133. doi: 10.1093/ajh/hpaa131.ABSTRACTMaintenance of upright blood pressure critically depends on the autonomic nervous system and its failure leads to neurogenic orthostatic hypotension (NOH). The most severe cases are seen in neurodegenerative disorders caused by abnormal α-synuclein deposits: multiple system atrophy (MSA), Parkinson's disease, Lewy body dementia, and pure autonomic failure (PAF). The development of novel treatments for NOH derives from research in these disorders. We provide a brief review of their underlying pathophysiology relevant to understand the rational...
Source: American Journal of Hypertension - Category: Cardiology Authors: Source Type: research
This study affirms the long-term safety and efficacy of scleral contact lens use in patients with keratoconus. PURPOSE This study aimed to evaluate the safety and efficacy of contemporary scleral contact lenses in the visual rehabilitation of the keratoconic population. METHODS A retrospective study of keratoconic subjects examined between 2013 and 2018 was conducted. Subjects were included regardless of age, sex, pre-existing morbidity, or scleral lens design. Only eyes fit successfully with scleral contact lenses for ≥1 year were included. Exclusion criteria were prior corneal surgery, dystrophy, degeneration, a...
Source: Optometry and Vision Science - Category: Opthalmology Tags: ORIGINAL INVESTIGATIONS Source Type: research
Discussion Bardet-Biedl syndrome (BBS) is a rare disorder. It is usually considered an autosomal recessive disorder but there is significant intra-familial variability. There are multiple genes (~20 currently) involved and it is believed that the phenotypic variability is due to “…differences in the total mutational load across different BBS associated genes….” It is a ciliopathy where mutation changes in proteins in the cilias causes problems in the cilia’s functioning particularly signaling. Cilia are important in signaling to maintain tissue and cellular homeostasis. Obviously screening o...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Bowel and Bladder Dysfunction (BBD) refers to a heterogeneous group of voiding disorders, accounting for an estimated 40 percent of pediatric urology visits. Symptoms of BBD include enuresis, urgency, and urinary retention, often accompanied by constipation. This pilot study aims to explore whether a pupillary response can be characterized for BBD, by examining the pupillary light reflex (PLR) before and after voiding among BBD patients. A total of 28 patients ages 7 to 21 were recruited from the Wetting, Infections, and Stooling Help (WISH) clinic at Children ’s National Medical Center.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research
CONCLUSIONS: Cardiopulmonary and renal reflex-induced neuroendocrine disorder may play an important role in the mechanism of NE in children with OSA, but this remains to be confirmed by animal studies. Other causes such as oxidative stress and inflammatory responses need to be further researched. PMID: 30446975 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - Category: Pediatrics Authors: Tags: World J Pediatr Source Type: research
Cooper, New York City, 20071.Thursday morning, I woke up, got my kids ready and took them to school. I came home, tidied up the rest of the dishes, and gave my dog Cooper an indulgent breakfast: a full can of her favorite soft dog food —not just a quarter of a can mixed in with her dry food like usual, but the whole thing, every last bit, all to herself. After she finished, I carried her to my car. We drove to the vet, where a kind receptionist showed me into an exam room, past a potted ficus plant and a cheerful wooden sign rea ding, “Think PAWS-ITIVELY!” I sat down on a bench. Cooper stuck her head behi...
Source: the underwear drawer - Category: Anesthesiology Authors: Source Type: blogs
CONCLUSIONS By following the modified STT, QL is established with minimal additional effort over a standard Schirmer test. We predict and observe four different subtypes of imbibition kinetics depending on how short or long the time is for first appearance of the wetting front and on how fast or slow is tear production. For slow lacrimal production rates, the standard 5-min wetting length does not correlate with basal tear production.
Source: Optometry and Vision Science - Category: Opthalmology Tags: Original Investigations Source Type: research
Conclusions: The wetting length was reduced by topical anesthesia, when instilled bilaterally and ipsilaterally. The latter response implies an ipsilateral, reflex sensory drive to lacrimal secretion. In the unanesthetized fellow eye, the reduction compared with its saline control was not quite significant. This implies a relative lack of central, sensory, reflex cross-innervation, although the possibility cannot entirely be ruled out. These results are relevant to the possibility of reflex lacrimal compensation from a normal fellow eye, in cases of unilateral corneal anesthesia.
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
In this study, we investigated the effect of tonsillectomy and adenoidectomy (T&A) on nocturnal enuresis (NE), salivary alphaamylase (sAA) in obstructive sleep apnea syndrome (OSAS) children with adenotonsillar hypertrophy (ATH). Methods: 37 children (Group A) were admitted for ATH and were found to have NE. The saliva samples were taken before and after polysomnography for the measure of sAA. After the T&A, the children were followed-up for 1 year. 35 OSAS children with NE but no T&A were as a NE watchful-waiting group (Group B), 32 subjects without OSAS or NE were as non-OSAS control (Group C), 42 cases who underwent T&A...
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research
CONCLUSION: In addition to the treatment of onychoschizia, onychorrhexis, and other signs of severe dessication of the nail plate, a barrier that regulates TOWL should be considered in the management onychomycosis to address barrier dysfunction and to promote stabilization of the damaged nail. Previously published flux values across the nail are reported to be 1.4 μg/cm2/day for efinaconazole and 204 μg/cm2/day for tavaborole. These values are substantially lower than the herein determined flux for both molecules across poly-ureaurethane 16%. A comparison of the data suggests that poly-ureaurethane 16%, if used prior...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
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