Mechanisms underlying the stimulatory effect of inhaled sulfur dioxide on vagal bronchopulmonary C-fibres.

This article is protected by copyright. All rights reserved. PMID: 31891193 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research

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We read with interest the recent publication by Morice et al. [1] "The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study" and the accompanying editorial by Turner and Birring [2] "Chronic cough: ATP, afferent pathways and hypersensitivity". The authors of both publications conclude the results are suggestive of two separate neuronal pathways mediating the cough reflex; however, there are significant issues with this interpretation of the data.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research
We thank J.A. Smith and co-workers for their interest in our paper [1]. Perhaps an even more ancient truth, that of William of Occam [2], should be applied to this discussion.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research
Conclusions: Daily auricular stimulation with capsaicin ointment for 2 weeks continued to improve the cough reflex sensitivity in elderly patients with dysphagia.Significance: Daily auricular stimulation with capsaicin ointment would be a safe and effective intervention to prevent pneumonia in elderly with a risk of aspiration. PMID: 32022628 [PubMed - as supplied by publisher]
Source: Acta Oto-Laryngologica - Category: ENT & OMF Authors: Tags: Acta Otolaryngol Source Type: research
Abstract RATIONALE: Capsaicin cough reflex sensitivity (C-CS) is associated with poorly controlled asthma, while its association with severe asthma remains unknown. OBJECTIVES: To determine the clinical impact of C-CS on severe asthma. METHODS: We prospectively enrolled 157 asthmatic patients (including 122 severe asthma patients who were in step 4/5 according to the GINA 2015 guideline) between November 2016 and October 2019. Capsaicin cough challenge was performed along with spirometry and assessment of biomarkers. The concentration required to induce at least five coughs by capsaicin (defined as C5) w...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
CONCLUSIONS: There seem to be clinical indicators that help in assessing the level of cough-related discomfort. PMID: 31950437 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Tags: Aging Clin Exp Res Source Type: research
AbstractChronic cough is one of the most common complaints for which patients in China seek medical attention. However, there are no nationwide data on the prevalence and socioeconomic burden of chronic cough. Although approximately 50% of Chinese men smoke, the vast majority of patients presenting for evaluation of chronic cough are never smokers. An equal sex distribution and a middle-aged predominance have been observed in the Chinese chronic cough population, despite demonstration of a higher cough reflex sensitivity in females and older patients. The role of air pollution in the distinct age and sex distribution requi...
Source: Lung - Category: Respiratory Medicine Source Type: research
In ophthalmic surgery, coughing during emergence from general anesthesia may have a detrimental effect on intraocular pressure. Tracheal suction during emergence may elicit this reflex. The optimal effect-site concentration (EC) of propofol to prevent triggering of the cough reflex during tracheal suctioning is unknown. The aim of this study is to assess the optimal EC of propofol for tracheal suctioning during emergence in patients undergoing ophthalmic surgery. Twenty-one patients were enrolled, all of them American Society of Anesthesiologists (ASA) physical status I or II non-smokers undergoing ophthalmic surgery. Ane...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Publication date: Available online 30 December 2019Source: Respiratory Physiology &NeurobiologyAuthor(s): Claudia Enrichi, Cristiano Zanetti, Caterina Gregorio, Isabella Koch, Agostino Vio, Katie Palmer, Francesca Meneghello, Francesco Piccione, Irene BattelAbstractIntroductionThere is no standard procedure to evaluated the peak of reflex cough flow (PCF-reflex) in the literature, which is important assessment in subjects with acquired brain injury and tracheostomy cannula. The present study aims to investigate the PCF of the reflex cough in a broad sample of healthy controls and, furthermore, the presence and the stre...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
Abstract Chronic cough is a common symptom of various chronic diseases. However, the vast majority of individuals with conditions that are commonly associated with cough, such as asthma and GERD, do not have chronic cough. This implies that cough reflex sensitivities differ among individuals. It is known that in the pathogenesis of cough, the nervous system plays a vital role. Recently more information about the role of the immune system and its interaction with the nervous system in the pathogenesis of cough has appeared in the literature. The aim of this article is to review the most recent data about the role o...
Source: Immunology Letters - Category: Allergy & Immunology Authors: Tags: Immunol Lett Source Type: research
We describe here the toxicology studies in beagle dogs that supported phase I testing of BIA 10–2474 in humans. A Maximum Tolerated Dose (MTD) study using once-a-day oral (capsule) application of BIA 10–2474 was first conducted to establish suitable dose levels for subsequent studies. Based on these results, 100 mg/kg/day was considered to be the MTD. The 4-week oral (capsule) toxicity study with a 3-week recovery period for BIA 10–2474 was therefore carried out at 20, 50 or 100 mg/kg/day. There were no changes recorded at 50 mg/kg/day and this was considered the oral No Observed Effect Level (NOEL)...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
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