Avoiding Myeloma Progression
Pomalyst Study Cycle 70: IgG was basically unchanged this month, compared with last month, at 1290 mg/dL. M-spike was 1.1 g/dL, compared with 1.0 last month, but it isn't very accurate and probably should have been 1.1 last month. Light chains wobbled a little but I never know what to think of them anyway. Dr YLH and I agreed that the myeloma remains stable after 70 28-day cycles. Myeloma Progression: I dread the day that my myeloma figures out how to defeat the Pomalyst. Every 28 days we check for problems, and I never really breathe easy until I get the numbers. So far, though, the Pomalyst (2 mg daily as a single agent) has kept my M-spike stable at around 1.1 or so. Why hasn't it evolved into a form that can evade the Pomalyst? Here is my theory: First, we know that myeloma is initially caused by a genetic mutation in a plasma cell or in a stem-cell-like precursor cell. That cell produces more cells just like it. The initial mutation may be spontaneous, but more likely is caused by damage to the cell's DNA by an environmental factor such as radiation or nasty chemicals. Benzene, for example, a component of gasoline, is a known cause of myeloma. That first mutation has to surmount several hurdles for the cell to become cancer, and most mutations fail, because they are detected and squashed by the immune system, or because the cell dies as it is programmed to do when something goes wrong. Mutations actually happen frequently, but very, very few become cancer - only ab...
Authors: Zhang J, Guo Y, Jia T, Guo H, Meng F, Xue S PMID: 31961111 [PubMed - as supplied by publisher]
Authors: Wang X, Wen Y, Xue L, Lu R, Tang H, Gao N, Zhang J, Xue Q PMID: 31961109 [PubMed - as supplied by publisher]
Authors: Wang P, Xue L, Wang L, Tang H, Lv C, Xue Q PMID: 31961108 [PubMed - as supplied by publisher]
Authors: Wu G, Ke J, Wang J, Zhu X, Xiong S PMID: 31961113 [PubMed - as supplied by publisher]
Anterior-dominant prostate cancer is harder to detect and presents with higher prostate-specific antigen (PSA) levels than prostate cancer in other locations, according to a database study.Reuters Health Information
When the patriarch of a Boston-area family was diagnosed with stage 3 pancreatic cancer, the family was told he needed to start treatment immediately.
In conclusion, these results indicated that SXD produced beneficial sedative and hypnotic bioactivities mediated by regulating the serotonergic and immune system.
AbstractGlioblastoma is a devastating tumor affecting the central nervous system with infiltrative capacity, high proliferation rate and chemoresistance. Therefore, it is urgent to find new therapeutic alternatives that improve this prognosis. Herein, we focused on tannic acid (TA) a polyphenol with antioxidant and antiproliferative activities. In this work, the antitumor and antioxidant effects of TA on rat (C6) glioblastoma cells and their cytotoxicity relative to primary astrocyte cultures were evaluated in vitro. Cells were exposed to TA of 6.25 to 75 μM for 24, 48 and/or 72 h. In addition, colony formati...
CONCLUSIONS: in our experience, surgery under ERAS protocols did not have an impact on decreasing global QOL in patients undergoing elective colorectal cancer surgery. The use of ERAS protocols in colorectal surgery achieves a positive influence, not only by decreasing surgical-related complications but also in terms of functional recovery, by decreasing the negative effects of surgery on patient QOL. PMID: 31960699 [PubMed - as supplied by publisher]
Say you’ve received a brand-new Fitbit for Christmas to get you started in tracking your exercise routine and reach your fitness goals. Great! However, there might be more going on behind the scenes of you keeping fit with the help of technology than meets the eye… At The Medical Futurist, we’re great fans of wearables (or health trackers) that help you make more informed decisions when it comes to your health. However, we can’t stay indifferent to the potential risks which using these devices entail such as individual tracking, inaccuracies and even supplementing harmful behaviours. Just lik...
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