Gastrointestinal mixed adenoneuroendocrine carcinoma (MANEC): An immunohistochemistry study of 13 microsatellite stable cases.
CONCLUSIONS: Gastrointestinal MANEC is a microsatellite stable tumor with nodular growth, which components might originate from a CD44-positive stem-like precursor cell. Lymph node status remains the most reliable prognostic parameter and agressivity seems to not be influenced by tumor budding degree or EMT-related features. The histologic aspect of metastatic component (neuroendocrine versus adenocarcinoma) should be included in the histopathological reports and might be used for establishing the proper-targeted therapy of MANEC.
PMID: 31704155 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - Category: Pathology Authors: Gurzu S, Fetyko A, Bara T, Banias L, Butiurca VO, Bara T, Tudorache V, Jung I Tags: Pathol Res Pract Source Type: research
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