Effects of high-fat diet on sympathetic neurotransmission in mesenteric arteries from Dahl salt-sensitive rat

Obesity hypertension is driven sympathetic neurotransmission to the heart and blood vessels. We tested the hypothesis that high-fat diet (HFD)-induced hypertension is driven by sympathetic neurotransmission to mesenteric arteries (MA) in male but not female Dahl salt-sensitive (Dahl ss) rat. Rats were fed a control diet (CD; 10  kcal% from fat) or HFD (60 kcal% from fat) beginning at 3 weeks (wk) of age; measurements were made at 10-, 17- and 24-wk. Body weight increased with HFD, age and sex. Mean arterial pressure (MAP) was higher in HFD versus CD rats from both sexes at 17- and 24-wk.

Source: Autonomic Neuroscience: Basic and Clinical - October 30, 2019 Category: Neuroscience Authors: Kibrom M. Alula, Rebecca Biltz, Hui Xu, Hannah Garver, Erinn L. Laimon-Thomson, Gregory D. Fink, James J. Galligan Source Type: research