Neuroimaging Studies in Patients With Mental Disorder and Co-occurring Substance Use Disorder: Summary of Findings

Introduction: More than half of psychiatric patients have comorbid substance use disorder (dual diagnosis) and this rate, confirmed by many epidemiological studies, is substantially higher compared to general population. Combined operation of self-medication mechanisms, common etiological factors, and mutually causative influences most likely accounts for comorbidity, which, despite its clinical prevalence, remains underrepresented in psychiatric research, especially in terms of neuroimaging. The current paper attempts to review and discuss all existing methodologically sustainable structural and functional neuroimaging studies in comorbid subjects published in the last 20 years.Methods: Performing a systematic PubMed/MEDLINE, Web of Science, and Cochrane databases search with predefined key-words and selection criteria, 43 structural and functional neuroimaging studies were analyzed.Results: Although markedly inconsistent and confounded by a variety of sources, available data suggest that structural brain changes are slightly more pronounced, yet not qualitatively different in comorbid patients compared to non-comorbid ones. In schizophrenia (SZ) patients, somewhat greater gray matter reduction is seen in cingulate cortex, dorsolateral prefrontal and frontotemporal cortex, limbic structures (hippocampus), and basal ganglia (striatum). The magnitude of structural changes is positively correlated to duration and severity of substance use, but it is important to note that at le...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

Related Links:

In today’s show, Gabe talks with Robert Kolker, author of the New York Times bestselling — and Oprah’s book club pick — book Hidden Valley Road. This non-fiction biography is the true story of a mid-century American family besieged by schizophrenia. Of their 12 children, 6 struggled with the severe mental disorder.  Join us for the incredible story of the family who became science’s greatest hope in the quest to understand schizophrenia. SUBSCRIBE &REVIEW   Guest information for ‘Robert Kolker- Large Family Schizophrenia’ Podcast Episode Robert Kolker is the...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Family General Interview Schizophrenia The Psych Central Show Source Type: blogs
Can people with schizophrenia fall in love? Can they date or even get married? In today’s episode, host Rachel Star Withers (a woman who lives with schizophrenia) and co-host Gabe Howard review their own past romantic experiences. They also interview Andrew and Stephanie Downing, authors of Marriage and Schizophrenia: Eyes on the Prize. Listen to learn about their incredible journey of overcoming schizophrenia and building a healthy, rewarding, and happy marriage. Computer Generated Transcript of “Love, Dating, Marriage with Schizophrenia” Episode Editor’s Note: Please be mindful that this trans...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Marriage and Divorce Motivation and Inspiration Podcast Relationships Sexuality Source Type: blogs
If I come forward with my mental illness, will it shame my family? If I go to a psychiatrist, does it mean I don’t have enough faith to heal myself? While these questions might seem odd to some people, these are very real worries for many in the Asian and Christian communities. In today’s episode, Dr. Esther Park, who is both Korean and Christian, explains the mental health stigma she has seen in both of these circles. Dr. Park helps clarify these issues and encourages people in these groups to understand the importance of seeking professional help. We want to hear from you — Please fill out our listener...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Disorders General Interview Mental Health and Wellness Podcast Spirituality Stigma The Psych Central Show Source Type: blogs
Does religion help or harm people with severe mental illness? In today’s Not Crazy podcast, Gabe and Lisa welcome Rachel Star Wither, host of the Inside Schizophrenia podcast, to discuss religion’s role (or lack thereof) in treating those struggling with schizophrenia or bipolar disorder. Rachel relates her personal experiences of mixing religion with her illness and shares how she currently manages to believe in God while keeping her faith “separate” from her symptoms. Tune in for a deep discussion on religion and severe mental illness, including Rachel’s 3-day exorcism experience at age 17....
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Disorders General Interview Not Crazy Podcast Schizophrenia Spirituality Source Type: blogs
  What is the link between addiction and mental illness? Is addiction a choice? In today’s Not Crazy podcast, Gabe and Lisa discuss whether addiction should be classified as a disease and whether or not it should require medical treatment. Gabe also shares his personal story of addiction and how it tied in with his bipolar disorder. What’s your take? Tune in for an in-depth discussion which covers every angle of this often controversial topic. (Transcript Available Below) Please Subscribe to Our Show: And We Love Written Reviews!  About The Not Crazy podcast Hosts Gabe Howard is an award-winning...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Addiction General Mental Health and Wellness Not Crazy Podcast Recovery Source Type: blogs
  Can a relationship work when one person has severe mental illness? In today’s Not Crazy podcast, Gabe and Lisa discuss dating with bipolar disorder. They share their own story of dating, marrying and divorcing under the umbrella of Gabe’s bipolar diagnosis, and discuss the ups and downs from both perspectives. What are some positive signs that the relationship can last? And what are the clues that you might need to call it quits? Tune in for a heartfelt discussion on living and dating with severe mental illness. (Transcript Available Below) Please Subscribe to Our Show: And We Love Written Reviews!&n...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Disorders General Marriage and Divorce Not Crazy Podcast Relationships Source Type: blogs
CONCLUSION: For the majority of the physicians surveyed, psychiatry represented a public health priority, and their prioritising provides a probable explanation for their positive perception of their role in the management of mental disorders. However, we went on to observe that a number of difficulties constituted obstacles to their role in management of mental disorders and induced them to refer their patients to psychiatrists. Our analysis highlighted the impact of continuing education on physicians' attitudes and the interest of collaboration between practitioners. Efforts in university teaching and continuous educatio...
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
Abstract All large population-based administrative studies currently indicate a significant comorbidity of adult attention deficit hyperactivity disorder (ADHD) with addictive, anxiety and in particular affective disorders. In these investigations the risk for one of these comorbid disorders increased with increasing age of the ADHD patients. The most recent genome-wide association and correlation studies also revealed indications for joint genetic risk factors of ADHD with, in particular unipolar depression, bipolar disorder, autism spectrum disorders, Tourette's syndrome and to a lesser extent schizophrenia...
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research
  Cannabis, weed, marijuana, pot. It goes by several names, but we all know what it smells like. As weed becomes more mainstream, we on the Not Crazy podcast want to know: Is marijuana really an effective treatment for anxiety? Is it just a coping mechanism? Or a vice? In today’s podcast, Gabe and Jackie look at the research and weigh out the evidence. They also interview Eileen Davidson, a rheumatoid arthritis patient who regularly uses marijuana as a medicine to see what she has to say. What’s your take? Tune in for an open-minded discussion about weed. (Transcript Available Below) SUBSCRIBE &REV...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic General Medications Not Crazy Podcast Source Type: blogs
Men and women experience schizophrenia differently; from the age of onset to symptoms and how society treats those with mental disorders.  Schizophrenic, Rachel Star Withers and co-host Gabe Howard continue the discussion of the differences from the last episode but change the focus to men.  Jason Jepson, an author who has schizophrenia joins for a man’s perspective and Dr. Hayden Finch returns to explain the clinical side of the issues. Highlights in “Schizophrenia in Men” Episode [01:30] Age of onset [04:00] Symptoms in men vs women [05:00] Interview with Jason Jepson [07:30] Jason discusses ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Men's Issues Psychiatry Psychology Living With Schizophrenia Mental Disorder Mental Health Mental Illness Symptoms Of Schizophrenia Source Type: blogs
More News: Addiction | Anxiety | Bipolar | Brain | Databases & Libraries | Epidemiology | Genetics | Mania | Men | Neurology | Neuroscience | Psychiatry | Schizophrenia | Science | Study