Tiotropium bromide, a long acting muscarinic receptor antagonist triggers intracellular calcium signalling in the heart.
CONCLUSIONS AND IMPLICATIONS: To our knowledge, this is the first pre-clinical study to show that Tiotropium bromide induces Ca2+ signalling via CaMKII and L-type Ca2+ channels to result in cell damage. This has significant clinical impact due to long term use of TB in COPD patients, and warrants assessment of cardiac drug safety.
PMID: 31618660 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - Category: Toxicology Authors: Cassambai S, Mee CJ, Renshaw D, Hussain A Tags: Toxicol Appl Pharmacol Source Type: research
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