Persistence pays off: After 8 ‑year follow-up, study finds robust and sustained antidepressant response to deep brain stimulation (DBS)

Conclusions: In>8 years of observation, most participants experienced a robust and sustained antidepressant response to SCC DBS. News in Context: Ethical issues raised around deep brain stimulation (DBS) research Closing the Circuit: Helen Mayberg’s research could revolutionize depression treatment Expo Day: Neuroenginnering, BPI, Arrowsmith Program &ARPF from SharpBrains
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology antidepressant area-25 brain pacemaker brain stimulation DBS deep-brain-stimulation depression Helen-Mayberg neurosurgical treatment Source Type: blogs

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Publication date: December 2019Source: Results in Physics, Volume 15Author(s): Mohammad Karbalaei, Daryoosh Dideban, Hadi HeidariAbstractThis paper presents the electrical characteristics of a short channel Silicon on Insulator (SOI) transistor with a graphene layer. The graphene sheet is used at the bottom of the channel close to the source side and a proportionally heavily p-type retrograde doping implanted in nearly middle of the channel. To increase the gate electrostatic control over the channel we incorporated a high-K material i.e. HfO2 as the gate oxide insulator. Due to Graphene growth and Retrograde Doping in the...
Source: Results in Physics - Category: Physics Source Type: research
Publication date: Available online 18 November 2019Source: Life SciencesAuthor(s): Erica Aparecida Gelfuso, Suelen Lorenzato Reis, Ana Maria Soares Pereira, Daiane Santos Rosa Aguiar, Renê Oliveira BeleboniAbstractDeficits in cognitive functions are often observed in epileptic patients, particularly in temporal lobe epilepsy (TLE). Evidence suggests that this cognitive decline can be associated with the occurrence of focal brain lesions, especially on hippocampus and cortex regions. We previously demonstrated that the erythrinian alkaloids, (+)-erythravine and (+)-11α-hydroxy-erythravine, inhibit seizures evoke...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 18 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Z Malihi, Z Wu, CMM Lawes, J Sluyter, D Waayer, L Toop, K-T Khaw, CA Camargo, R ScraggABSTRACTWith increasing numbers of randomized controlled trials (RCTs) investigating potential health events of vitamin D supplementation, a better understanding is required of the risk factors for adverse events and for study withdrawals. This analysis aimed to identify baseline risk factors of reporting an adverse event in a multi-year randomized double-blinded placebo-controlled trial of vitamin D supplementati...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Authors: Yamashita K, Ghafoori E, Silvernagel J, Ashton J, J Dosdall D, MacLeod R, Ranjan R Abstract Radiofrequency (RF) ablation results in creation of acute edema which can lead to temporary disruption of electrical propagation.The goal of this study was to find the effective contact force (CF) to minimize edema formation in comparison to the lesion size.Ventricular RF lesions (n = 49) were created by a CF-sensing catheter in a canine model (n = 10) with varying force for 30 seconds. Animals underwent T2-weighted (T2w) and late gadolinium enhancement MRI (LGE-MRI) immediately after ablation and at 12 weeks. Acute...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
ConclusionsThe presence of TD is associated with worse HRQoL and social withdrawal. The most severe impact of TD is on physical aspects of patients ’ HRQoL.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionsThe Y-BOCS-BE is a valuable tool for assessing BED symptoms. Maximization of Y-BOCS-BE reliability and validity at later study time points may be related to both treatment effects and improved insight into BED by participants during the study.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionsThese results suggest that O/P ratio can be related to current and future engagement in pro-environmental behavior and improvement in subjective well-being which could lead to an environmentally sustainable society with enhanced quality of life.
Source: Quality of Life Research - Category: Health Management Source Type: research
We can link grain consumption with causing or worsening some of the most mysterious brain disorders that have eluded the medical community for years, such as schizophrenia, epilepsy, depression, bipolar disorder, and, more recently, autism and ADHD. Are you and your kids unknowingly under the influence of opiates? Opiates come disguised in many forms.   Grains contain opiates. Not figuratively, but quite literally. These opiates are not too different from morphine or heroin. Yes, wheat and grains, cleverly disguised as a multigrain loaf of bread to make sandwiches or a hot, steamy plate of macaroni and cheese for the ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates adhd bipolar disorder brain fog concentration Depression diy health Dr. Davis epilepsy grain-free headaches Inflammation mind mood swings OCD opiates schizophrenia undoctored wheat belly Wheat Belly Tot Source Type: blogs
Conclusion: These results support the validity and reliability of the new tablet-based electronic Columbia-Suicide Severity Rating Scale. This will allow the inclusion of the electronic Columbia-Suicide Severity Rating Scale in a wider range of clinical studies, particularly where a tablet is also being used to collect other study data. Introduction Prospective assessment of suicidal ideation and behavior (SIB) is a critical step in many clinical trials. The United States Food and Drug Administration (FDA) mandates prospective SIB in “all clinical trials involving any drug being developed for any psychiatric indicati...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools Current Issue Depression Devices Drug Development Evaluations Original Research Patient Assessment Psychiatry Scales Suicidality Technology Trial Methodology C-SSR Columbia-Suicide Severity Rating Scale elect Source Type: research
Conclusion The SCIP is reliable and valid diagnostic interview, is compatible with experimental psychopathology and personalized psychiatry research, and is in line with the NIMH RDoC framework. The SCIP Instruction Manual is also available for download by visiting http://innovationscns.com/wp-content/uploads/SCIP_Instruction_Manual_2015.pdf. Acknowledgment Dr. Aboraya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses. References 1.     Stone M. Healing the Mind: A History of Psychiatry from Antiquity to the Present. In: ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools Current Issue Evaluations Psychiatry Reliability of Diagnoses Review Scales Trial Methodology descriptive psychopathology diagnostic criteria dimensional scores Psychiatric interview SCIP Standard for Clinicians Source Type: research
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