Psychiatric disorders and SLC6A4 gene variants: possible effects on alcohol dependence and alzheimer's disease.

In this study we aimed to evaluate the pleiotropic nature of SLC6A4 alterations and their association with the overall risk of brain diseases rather than disorder-specific. SLC6A4 variants, namely 5HTTLPR, STin2, rs2066713, rs25531, rs4251417, rs6354 and rs7224199 were investigated in 4 independent cohorts of subjects with specific psychiatric disorders, including Alcohol dependence disorder (ALC), Alzheimer disease (ALZ), Schizophrenia (SCZ) and Bipolar disorder (BPD). Other variables (biochemical parameters and Psychiatric scales scores) were also tested for association. SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR pd = 9.25 × 10-03, pr = 7.24 × 10-03; rs2066713 pd = 6.35 × 10-08; rs25531 pd = 2.95 × 10-02; rs4251417 pd = 2.46 × 10-03), and ALZ (rs6354 pr = 1.22 × 10-02; rs7224199 pd = 1.00 × 10-08, pr = 2.65 × 10-02) cohorts. Some associations were also observed on exploratory analyses. Our findings did not reveal any major influence on SCZ and BPD development; On the other hand, some alteration of the SLC6A4 sequence were associated with an increased risk of ALC and ALZ disorders, suggesting...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research

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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Disorders General Inside Schizophrenia Mental Health and Wellness Active psychosis Delusions Delusions Hallucinations Living with Schizoprenia Mental Disorder Mental Illness Psychology psychotic Psychotic Break Source Type: blogs
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Peer Support Self-Help Source Type: blogs
3030Purpose: The purpose of this study is to evaluate altered regional histone deacetylase (HDAC) expression (density and distribution) in Alcohol Use Disorder (AUD) patients and age- and sex-matched healthy controls, using [11C]Martinostat as a PET radiotracer. We aim to measure HDAC density and distribution in the brain of AUD patients. We will test the hypothesis that HDAC enzyme expression is altered in AUD brains. We will take advantage of a combined PET/MRI system to collect simultaneous PET and structural MRI to obtain high-resolution spatial maps. This will address fundamental questions about chromatin modifying en...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Technologist Posters Source Type: research
When it comes to making big changes in our lives, most of us fail. Oh, the change might stick for a while, but eventually we go back to our unchanged selves. Why is that? Why can’t we maintain change for the long-term? In this episode, you’ll learn different reasons for this, but even better, how to make the long-term changes stick. Subscribe to Our Show! And Remember to Review Us! About Our Guest Eric Zimmer is a dad, serial entrepreneur, podcast host, behavior coach, and author. He is endlessly inspired by the quest for a greater understanding of how our minds work and how to intentional...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior General Habits The Psych Central Show change Gabe Howard Vincent M. Wales Source Type: blogs
CONCLUSION: Older men with a psychotic disorder have nearly three times greater risk of developing dementia than those without psychosis. The pathways linking psychotic disorders to dementia remain unclear but may involve mechanisms other than those associated with Alzheimer's disease and other common dementia syndromes. PMID: 29564993 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research
We examined and updated a master list of clinically relevant and susceptibility genes associated with SCZ reported in the literature and genomic databases dedicated to gene discovery for characterization of SCZ genes. We used the commercially available GeneAnalytics computer-based gene analysis program and integrated genomic databases to create a molecular profile of the updated list of 608 SCZ genes to model their impact in select categories (tissues and cells, diseases, pathways, biological processes, molecular functions, phenotypes and compounds) using specialized GeneAnalytics algorithms. Genes for schizophrenia were p...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
This study compared the next-day residual effects of acute and steady-state nighttime doses of flibanserin (100mg/day and 200mg/day) on simulated driving performance and cognition in healthy female subjects. Objective: To test for negative effects on measures of next-day simulated driving performance and cognitive testing Methods: Healthy, premenopausal females (18–-50 years of age) were randomized to flibanserin (100mg or 200mg), zopiclone (7.5mg), or matching placebos the evening prior to testing in a double-blind, placebo-controlled, Latin-square design, with four-way, four-period crossover (n=83). Zopiclone was s...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Drug Development Genetics Supplements Trial Methodology CNS Summit poster presentation abstracts Source Type: research
Conclusion: Aripiprazole may be useful for treatment of apathy syndrome. Its role in treatment of apathy requires further investigation in clinical trials. Introduction Apathy is a profound loss of motivation not attributed to decreased level of consciousness, cognitive impairment, or emotional distress.[1] Apathy refers to a set of behavioral, emotional, and cognitive features such reduced interest and participation of activities of daily life. Another prime characteristic is lack of initiative or an absence of responsiveness to stimuli as demonstrated by a lack of self initiated action.[2] Apathy is highly prevalent in n...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue Mood Disorders Psychiatry Psychopharmacology apathy aripiprazole depression Source Type: research
Publication date: Available online 7 February 2015 Source:International Journal of Psychophysiology Author(s): Bahar Güntekin , Erol Başar In the last decade, the brain's oscillatory responses have invaded the literature. The studies on delta (0.5–3.5Hz) oscillatory responses in humans upon application of cognitive paradigms showed that delta oscillations are related to cognitive processes, mainly in decision making and attentional processes. The present manuscript comprehensively reviews the studies on delta oscillatory responses upon cognitive stimulation in healthy subjects and in different pathologies, na...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
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