Fetal Safety of Dydrogesterone Exposure in the First Trimester of Pregnancy

ConclusionsDYD confers teratogenic effects after exposure to the recommended doses in pregnant women. The risks of hypospadias and cryptorchidism have biological plausibility by the known effects on male genitalia, as is the risk for spina bifida, by the proven decrease in folic acid levels. Some of these adverse fetal effects appear to be further augmented by concomitant use of IVF and ART.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research