Natural fermentation product butyrate improves the metabolic disorder and gut microbiome dysbiosis in mice induced by a high-fat diet

Conclusion: Butyrate can induce AMPK activation and GLUT4 expression in the adipose, improving cardiovascular disease-related metabolic disorder, resisting HFD- induced gut microbiome dysbiosis, and promoting resolvin E and lipoxin biosynthesis. Oral supplement of natural fermentation product butyrate can be a potential strategy for preventing cardiovascular diseases. KEYWORDS: AMPK, GLUT-4, Metabolomics, Sodium butyrate, 16s rRNA sequencing
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research