GSE135945 Integrative Epigenomic and Transcriptomic Analysis Reveals Robust Metabolic Switching During Intermittent Fasting in the Brain

Contributors : Gavin Y Ng ; Dominic P Sheng ; Sung W Kang ; David Y Fann ; Joonki Kim ; Asfa Alli-Shaik ; Vardan Karamyan ; Eitan Okun ; Christopher G Sobey ; Thameem Dheen ; Jayantha Gunaratne ; Mark P Mattson ; Roger S Foo ; Dong-Gyu Jo ; Thiruma V ArumugamSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIntermittent fasting (IF) is a dietary regimen aimed to restrict energy intake via alternate periods of ad libitum food consumption and fasting, without compromise of nutritional composition intake. Prophylactic IF have been well-established in many animal studies to promote longevity as well as ameliorate the development and manifestation of age-related diseases such as cardiovascular, neurodegenerative as well as metabolic diseases. However, while vast experimental evidences have pointed out that IF is able to exert plethora effects against these diseases, understanding with regards to the underlying mechanisms remain in their infancy. Recently, an emerging area of research in the field of epigenetics have been shown to be a cornerstone in mediating the interaction between environmental factors and genome status. IF is a lifestyle intervention that may serves as potential environmental influences over the epigenome status of individuals. However, there is no current information available that shows that IF can induce epigenetic changes. Here, we show that IF is ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research